tetano
Editor, Senior Moderator
Curr Oncol
. 2022 Mar 26;29(4):2312-2325.
doi: 10.3390/curroncol29040188.
Comprehensive Treatment of Hematological Patients with SARS-CoV-2 Infection Including Anti-SARS-CoV-2 Monoclonal Antibodies: A Single-Center Experience Case Series
Göran Ramin Boeckel[SUP] 1 2 [/SUP], Silke Dorothea Hölscher[SUP] 1 [/SUP], Christin Bürger[SUP] 1 [/SUP], Torid Jacob[SUP] 1 [/SUP], Carolin Krekeler[SUP] 3 [/SUP], Evgenii Shumilov[SUP] 3 [/SUP], Christian Reicherts[SUP] 3 [/SUP], Annalen Bleckmann[SUP] 3 [/SUP], Georg Lenz[SUP] 3 [/SUP], Richard Vollenberg[SUP] 1 [/SUP], Phil-Robin Tepasse[SUP] 1 [/SUP]
Affiliations
Abstract
Patients with hematologic malignancies are at high risk of exacerbated condition and higher mortality from coronavirus disease 2019 (COVID-19). Bamlanivimab, casirivimab/imdevimab combination, and sotrovimab are monoclonal antibodies (mABs) that can reduce the risk of COVID-19-related hospitalization. Clinical effectiveness of bamlanivimab and casirivimab/imdevimab combination has been shown for the Delta variant (B.1.617.2), but the effectiveness of the latter treatment against the Omicron variant (B.1.1.529) has been suggested to be reduced. However, the tolerability and clinical usage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific mABs in patients with hematologic malignancies are less specified. We present a retrospective case series analysis of all SARS-CoV-2-infected patients with hematologic malignancies who received SARS-CoV-2-specific mABs at our facility between February and mid-December 2021. A total of 13 COVID-19 patients (pts) with at least one malignant hematologic diagnosis received SARS-CoV-2-specific mABs at our facility, with 3 pts receiving bamlanivimab and 10 pts receiving casirivimab/imdevimab combination. We observed SARS-CoV-2 clearance in five cases. Furthermore, we observed a reduction in the necessity for oxygen supplementation in five cases where the application was administered off-label. To the best of our knowledge, we present the largest collection of anecdotal cases of SARS-CoV-2-specific monoclonal antibody use in patients with hematological malignancies. Potential benefit of mABs may be reduced duration and/or clearance of persistent SARS-CoV-2 infection.
Keywords: COVID-19; SARS-CoV-2; antibody therapy; bamlanivimab; cancer; casirivimab; hematologic malignancies; imdevimab.
. 2022 Mar 26;29(4):2312-2325.
doi: 10.3390/curroncol29040188.
Comprehensive Treatment of Hematological Patients with SARS-CoV-2 Infection Including Anti-SARS-CoV-2 Monoclonal Antibodies: A Single-Center Experience Case Series
Göran Ramin Boeckel[SUP] 1 2 [/SUP], Silke Dorothea Hölscher[SUP] 1 [/SUP], Christin Bürger[SUP] 1 [/SUP], Torid Jacob[SUP] 1 [/SUP], Carolin Krekeler[SUP] 3 [/SUP], Evgenii Shumilov[SUP] 3 [/SUP], Christian Reicherts[SUP] 3 [/SUP], Annalen Bleckmann[SUP] 3 [/SUP], Georg Lenz[SUP] 3 [/SUP], Richard Vollenberg[SUP] 1 [/SUP], Phil-Robin Tepasse[SUP] 1 [/SUP]
Affiliations
- PMID: 35448162
- DOI: 10.3390/curroncol29040188
Abstract
Patients with hematologic malignancies are at high risk of exacerbated condition and higher mortality from coronavirus disease 2019 (COVID-19). Bamlanivimab, casirivimab/imdevimab combination, and sotrovimab are monoclonal antibodies (mABs) that can reduce the risk of COVID-19-related hospitalization. Clinical effectiveness of bamlanivimab and casirivimab/imdevimab combination has been shown for the Delta variant (B.1.617.2), but the effectiveness of the latter treatment against the Omicron variant (B.1.1.529) has been suggested to be reduced. However, the tolerability and clinical usage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific mABs in patients with hematologic malignancies are less specified. We present a retrospective case series analysis of all SARS-CoV-2-infected patients with hematologic malignancies who received SARS-CoV-2-specific mABs at our facility between February and mid-December 2021. A total of 13 COVID-19 patients (pts) with at least one malignant hematologic diagnosis received SARS-CoV-2-specific mABs at our facility, with 3 pts receiving bamlanivimab and 10 pts receiving casirivimab/imdevimab combination. We observed SARS-CoV-2 clearance in five cases. Furthermore, we observed a reduction in the necessity for oxygen supplementation in five cases where the application was administered off-label. To the best of our knowledge, we present the largest collection of anecdotal cases of SARS-CoV-2-specific monoclonal antibody use in patients with hematological malignancies. Potential benefit of mABs may be reduced duration and/or clearance of persistent SARS-CoV-2 infection.
Keywords: COVID-19; SARS-CoV-2; antibody therapy; bamlanivimab; cancer; casirivimab; hematologic malignancies; imdevimab.