tetano
Editor, Senior Moderator
Curr Mol Med
. 2022 Jan 6.
doi: 10.2174/1566524022666220106160403. Online ahead of print.
Nucleic Acid-Based Vaccines Platform Against Covid-19 Pandemic
Roghayyeh Baghban[SUP] 1 [/SUP], Shirin Mahmoodi[SUP] 2 [/SUP]
Affiliations
Abstract
Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has affected millions of people globally, in this regard, known as a pandemic by the World Health Organization (WHO). There is sufficient scientific evidence that a preventive COVID-19 vaccine is the most effective approach to combat with COVID-19 pandemic, therefore there is an essential need for safe and protective vaccines to fight it.
Methods: Global efforts in developing a vaccine against COVID-19 have resulted in the development of different vaccine platforms with various safety and efficacy including live-attenuated vaccines, inactivated vaccines, subunit vaccines, and nucleic acid-based vaccines against coronavirus disease 2019 (COVID-19). Nucleic acid-based vaccines consist of mRNA and DNA vaccines have shown promising results in stimulating cellular and humoral immune responses properly against COVID-19, which their rapid and easy manufacturing process compared to others have made them considerable. mRNA-based vaccines platform by Pfizer/BioNtech and Moderna companies are the first approved vaccines for emergency use against COVID-19.
Results: This narrative review highlights the recent advances in developing nucleic acid-based vaccines for COVID-19.
Conclusion: The fast global dissemination of the coronavirus has highlighted the urgent necessity to build an efficient vaccine to inhibit disease. Cooperative attempts throughout the world have paid to the fast and unprecedented production of vaccines. Much needs to be learned regarding SARSCoV-2 and vaccine development against it.
Keywords: COVID-19; DNA vaccines; Efficacy; Protective; Safety; mRNA vaccines.
. 2022 Jan 6.
doi: 10.2174/1566524022666220106160403. Online ahead of print.
Nucleic Acid-Based Vaccines Platform Against Covid-19 Pandemic
Roghayyeh Baghban[SUP] 1 [/SUP], Shirin Mahmoodi[SUP] 2 [/SUP]
Affiliations
- PMID: 34994327
- DOI: 10.2174/1566524022666220106160403
Abstract
Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has affected millions of people globally, in this regard, known as a pandemic by the World Health Organization (WHO). There is sufficient scientific evidence that a preventive COVID-19 vaccine is the most effective approach to combat with COVID-19 pandemic, therefore there is an essential need for safe and protective vaccines to fight it.
Methods: Global efforts in developing a vaccine against COVID-19 have resulted in the development of different vaccine platforms with various safety and efficacy including live-attenuated vaccines, inactivated vaccines, subunit vaccines, and nucleic acid-based vaccines against coronavirus disease 2019 (COVID-19). Nucleic acid-based vaccines consist of mRNA and DNA vaccines have shown promising results in stimulating cellular and humoral immune responses properly against COVID-19, which their rapid and easy manufacturing process compared to others have made them considerable. mRNA-based vaccines platform by Pfizer/BioNtech and Moderna companies are the first approved vaccines for emergency use against COVID-19.
Results: This narrative review highlights the recent advances in developing nucleic acid-based vaccines for COVID-19.
Conclusion: The fast global dissemination of the coronavirus has highlighted the urgent necessity to build an efficient vaccine to inhibit disease. Cooperative attempts throughout the world have paid to the fast and unprecedented production of vaccines. Much needs to be learned regarding SARSCoV-2 and vaccine development against it.
Keywords: COVID-19; DNA vaccines; Efficacy; Protective; Safety; mRNA vaccines.