tetano
Editor, Senior Moderator
Curr Mol Med
. 2023 Apr 10.
doi: 10.2174/1566524023666230410093243. Online ahead of print.
Covid-19 prevention and treatment by targeting Fc-fusion proteins: An experience to fight emerging diseases
Hamed Zare[SUP] 1 [/SUP], Tahereh Farkhondeh[SUP] 2 [/SUP], Hamid Bakherad[SUP] 3 [/SUP], Hengame Sharifi[SUP] 4 [/SUP], Maryam Hosseinzade Shirzeyli[SUP] 5 [/SUP], Saeed Samarghandian[SUP] 6 [/SUP], Fahimeh Ghasemi[SUP] 7 8 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (Covid-19) pandemic has been considered a major threat to human health. Effective therapeutic approaches are urgently required. Spike protein and the Angiotensin-converting enzyme 2 (ACE2) receptors have critical roles in SARS-CoV-2 infection. As a result, these two proteins are considered potential targets for the development of a wide variety of biotherapeutics and vaccines for controlling Covid-19. The fusion proteins have desirable medicinal properties, including high serum half-life, stability, and solubility in the body. Moreover, other Fc-fusion proteins used to treat other diseases have no known side effects. These Fc-fusion proteins are valuable biopharmaceuticals and have been proposed as therapeutic candidates for the treatment and prevention of Covid-19 owing to their potential therapeutic benefits.
Keywords: ACE2; Covid-19; Fc-fusion proteins; SARS-CoV-2; Spike protein; receptor.
. 2023 Apr 10.
doi: 10.2174/1566524023666230410093243. Online ahead of print.
Covid-19 prevention and treatment by targeting Fc-fusion proteins: An experience to fight emerging diseases
Hamed Zare[SUP] 1 [/SUP], Tahereh Farkhondeh[SUP] 2 [/SUP], Hamid Bakherad[SUP] 3 [/SUP], Hengame Sharifi[SUP] 4 [/SUP], Maryam Hosseinzade Shirzeyli[SUP] 5 [/SUP], Saeed Samarghandian[SUP] 6 [/SUP], Fahimeh Ghasemi[SUP] 7 8 [/SUP]
Affiliations
- PMID: 37038291
- DOI: 10.2174/1566524023666230410093243
Abstract
The coronavirus disease 2019 (Covid-19) pandemic has been considered a major threat to human health. Effective therapeutic approaches are urgently required. Spike protein and the Angiotensin-converting enzyme 2 (ACE2) receptors have critical roles in SARS-CoV-2 infection. As a result, these two proteins are considered potential targets for the development of a wide variety of biotherapeutics and vaccines for controlling Covid-19. The fusion proteins have desirable medicinal properties, including high serum half-life, stability, and solubility in the body. Moreover, other Fc-fusion proteins used to treat other diseases have no known side effects. These Fc-fusion proteins are valuable biopharmaceuticals and have been proposed as therapeutic candidates for the treatment and prevention of Covid-19 owing to their potential therapeutic benefits.
Keywords: ACE2; Covid-19; Fc-fusion proteins; SARS-CoV-2; Spike protein; receptor.