tetano
Editor, Senior Moderator
Curr Med Sci
. 2021 Feb;41(1):24-30.
doi: 10.1007/s11596-021-2313-6. Epub 2021 Feb 13.
Corticosteroids Treatment of Patients with Coronavirus Disease 2019: A Propensity Score Matching Study
Meng-Yuan Liang[SUP] #[/SUP][SUP] 1 [/SUP], Ping Chen[SUP] #[/SUP][SUP] 1 [/SUP], Miao He[SUP] 1 [/SUP], Jian Tang[SUP] 1 [/SUP], Hui Li[SUP] 1 [/SUP], Xin-Liang He[SUP] 1 [/SUP], Ya-Ya Zhou[SUP] 1 [/SUP], Si-Wei Feng[SUP] 1 [/SUP], Yu-E Xue[SUP] 1 [/SUP], Yao Liu[SUP] 1 [/SUP], Yan-Ling Ma[SUP] 2 [/SUP], Jian-Chu Zhang[SUP] 3 [/SUP]
Affiliations
Abstract
The role of corticosteroids in the treatment of Coronavirus disease 2019 (COVID-19) is controversial. In the present study, we evaluated the effects of adjuvant corticosteroids treatment on the outcome of patients with COVID-19 (n=966), using Propensity Score Matching to adjust for potential differences between the corticosteroids group (n=289) and the non-corticosteroids group (n=677). Analysis of data without adjusting differences in baseline characteristics indicated that the proportion of mechanical ventilation and the mortality was higher in the corticosteroids treatment group in total or severe/critical patients. The duration of viral shedding was longer in the non-corticosteroids treatment group in total or general/mild patients. After adjusting the difference between the corticosteroids and non-corticosteroids treatment group, the analysis revealed that the use of corticosteroids had no effect on the duration of viral shedding, in-hospital mortality or 28-day mortality.
Keywords: coronavirus disease 2019; corticosteroids; mortality; severe acute respiratory syndrome coronavirus 2; viral shedding.
. 2021 Feb;41(1):24-30.
doi: 10.1007/s11596-021-2313-6. Epub 2021 Feb 13.
Corticosteroids Treatment of Patients with Coronavirus Disease 2019: A Propensity Score Matching Study
Meng-Yuan Liang[SUP] #[/SUP][SUP] 1 [/SUP], Ping Chen[SUP] #[/SUP][SUP] 1 [/SUP], Miao He[SUP] 1 [/SUP], Jian Tang[SUP] 1 [/SUP], Hui Li[SUP] 1 [/SUP], Xin-Liang He[SUP] 1 [/SUP], Ya-Ya Zhou[SUP] 1 [/SUP], Si-Wei Feng[SUP] 1 [/SUP], Yu-E Xue[SUP] 1 [/SUP], Yao Liu[SUP] 1 [/SUP], Yan-Ling Ma[SUP] 2 [/SUP], Jian-Chu Zhang[SUP] 3 [/SUP]
Affiliations
- PMID: 33582901
- DOI: 10.1007/s11596-021-2313-6
Abstract
The role of corticosteroids in the treatment of Coronavirus disease 2019 (COVID-19) is controversial. In the present study, we evaluated the effects of adjuvant corticosteroids treatment on the outcome of patients with COVID-19 (n=966), using Propensity Score Matching to adjust for potential differences between the corticosteroids group (n=289) and the non-corticosteroids group (n=677). Analysis of data without adjusting differences in baseline characteristics indicated that the proportion of mechanical ventilation and the mortality was higher in the corticosteroids treatment group in total or severe/critical patients. The duration of viral shedding was longer in the non-corticosteroids treatment group in total or general/mild patients. After adjusting the difference between the corticosteroids and non-corticosteroids treatment group, the analysis revealed that the use of corticosteroids had no effect on the duration of viral shedding, in-hospital mortality or 28-day mortality.
Keywords: coronavirus disease 2019; corticosteroids; mortality; severe acute respiratory syndrome coronavirus 2; viral shedding.