tetano
Editor, Senior Moderator
Curr Med Sci. 2020 Mar 24. doi: 10.1007/s11596-020-2172-6. [Epub ahead of print]
Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China.
Zheng F[SUP]1[/SUP], Liao C[SUP]2[/SUP], Fan QH[SUP]3[/SUP], Chen HB[SUP]1[/SUP], Zhao XG[SUP]2[/SUP], Xie ZG[SUP]3[/SUP], Li XL[SUP]4[/SUP], Chen CX[SUP]4[/SUP], Lu XX[SUP]5[/SUP], Liu ZS[SUP]5[/SUP], Lu W[SUP]6[/SUP], Chen CB[SUP]6[/SUP], Jiao R[SUP]7[/SUP], Zhang AM[SUP]7[/SUP], Wang JT[SUP]8[/SUP], Ding XW[SUP]8[/SUP], Zeng YG[SUP]9[/SUP], Cheng LP[SUP]9[/SUP], Huang QF[SUP]10[/SUP], Wu J[SUP]11[/SUP], Luo XC[SUP]11[/SUP], Wang ZJ[SUP]1[/SUP], Zhong YY[SUP]12[/SUP], Bai Y[SUP]13[/SUP], Wu XY[SUP]14[/SUP], Jin RM[SUP]15[/SUP].
Author information
Abstract
Since December 2019, COVID-19 has occurred unexpectedly and emerged as a health problem worldwide. Despite the rapidly increasing number of cases in subsequent weeks, the clinical characteristics of pediatric cases are rarely described. A cross-sectional multicenter study was carried out in 10 hospitals across Hubei province. A total of 25 confirmed pediatric cases of COVID-19 were collected. The demographic data, epidemiological history, underlying diseases, clinical manifestations, laboratory and radiological data, treatments, and outcomes were analyzed. Of 25 hospitalized patients with COVID-19, the boy to girl ratio was 1.27:1. The median age was 3 years. COVID-19 cases in children aged <3 years, 3.6 years, and ≥6-years patients were 10 (40%), 6 (24%), and 9 (36%), respectively. The most common symptoms at onset of illness were fever (13 [52%]), and dry cough (11 [44%]). Chest CT images showed essential normal in 8 cases (33.3%), unilateral involvement of lungs in 5 cases (20.8%), and bilateral involvement in 11 cases (45.8%). Clinical diagnoses included upper respiratory tract infection (n=8), mild pneumonia (n=15), and critical cases (n=2). Two critical cases (8%) were given invasive mechanical ventilation, corticosteroids, and immunoglobulin. The symptoms in 24 (96%) of 25 patients were alleviated and one patient had been discharged. It was concluded that children were susceptible to COVID-19 like adults, while the clinical presentations and outcomes were more favorable in children. However, children less than 3 years old accounted for majority cases and critical cases lied in this age group, which demanded extra attentions during home caring and hospitalization treatment.
KEYWORDS:
COVID-19; SARS-CoV-2; children; coronavirus
PMID:32207032DOI:10.1007/s11596-020-2172-6
Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China.
Zheng F[SUP]1[/SUP], Liao C[SUP]2[/SUP], Fan QH[SUP]3[/SUP], Chen HB[SUP]1[/SUP], Zhao XG[SUP]2[/SUP], Xie ZG[SUP]3[/SUP], Li XL[SUP]4[/SUP], Chen CX[SUP]4[/SUP], Lu XX[SUP]5[/SUP], Liu ZS[SUP]5[/SUP], Lu W[SUP]6[/SUP], Chen CB[SUP]6[/SUP], Jiao R[SUP]7[/SUP], Zhang AM[SUP]7[/SUP], Wang JT[SUP]8[/SUP], Ding XW[SUP]8[/SUP], Zeng YG[SUP]9[/SUP], Cheng LP[SUP]9[/SUP], Huang QF[SUP]10[/SUP], Wu J[SUP]11[/SUP], Luo XC[SUP]11[/SUP], Wang ZJ[SUP]1[/SUP], Zhong YY[SUP]12[/SUP], Bai Y[SUP]13[/SUP], Wu XY[SUP]14[/SUP], Jin RM[SUP]15[/SUP].
Author information
Abstract
Since December 2019, COVID-19 has occurred unexpectedly and emerged as a health problem worldwide. Despite the rapidly increasing number of cases in subsequent weeks, the clinical characteristics of pediatric cases are rarely described. A cross-sectional multicenter study was carried out in 10 hospitals across Hubei province. A total of 25 confirmed pediatric cases of COVID-19 were collected. The demographic data, epidemiological history, underlying diseases, clinical manifestations, laboratory and radiological data, treatments, and outcomes were analyzed. Of 25 hospitalized patients with COVID-19, the boy to girl ratio was 1.27:1. The median age was 3 years. COVID-19 cases in children aged <3 years, 3.6 years, and ≥6-years patients were 10 (40%), 6 (24%), and 9 (36%), respectively. The most common symptoms at onset of illness were fever (13 [52%]), and dry cough (11 [44%]). Chest CT images showed essential normal in 8 cases (33.3%), unilateral involvement of lungs in 5 cases (20.8%), and bilateral involvement in 11 cases (45.8%). Clinical diagnoses included upper respiratory tract infection (n=8), mild pneumonia (n=15), and critical cases (n=2). Two critical cases (8%) were given invasive mechanical ventilation, corticosteroids, and immunoglobulin. The symptoms in 24 (96%) of 25 patients were alleviated and one patient had been discharged. It was concluded that children were susceptible to COVID-19 like adults, while the clinical presentations and outcomes were more favorable in children. However, children less than 3 years old accounted for majority cases and critical cases lied in this age group, which demanded extra attentions during home caring and hospitalization treatment.
KEYWORDS:
COVID-19; SARS-CoV-2; children; coronavirus
PMID:32207032DOI:10.1007/s11596-020-2172-6