tetano
Editor, Senior Moderator
Curr Med Chem
. 2021 Oct 26.
doi: 10.2174/0929867328666211026124033. Online ahead of print.
The Role of Endothelial Related Circulating Biomarkers in COVID-19. A Systematic Review and Meta-analysis
Stamatios Lampsas[SUP] 1 [/SUP], Paraskevas Tsaplaris[SUP] 1 [/SUP], Panteleimon Pantelidis[SUP] 1 [/SUP], Evangelos Oikonomou[SUP] 1 [/SUP], Georgios Marinos[SUP] 2 [/SUP], Georgios Charalambous[SUP] 1 [/SUP], Nektarios Souvaliotis[SUP] 1 [/SUP], Vasiliki-Chara Mystakidi[SUP] 1 [/SUP], Athina Goliopoulou[SUP] 1 [/SUP], Efstratios Katsianos[SUP] 1 [/SUP], Gerasimos Siasos[SUP] 1 [/SUP], Michael-Andrew Vavuranakis[SUP] 1 [/SUP], Costas Tsioufis[SUP] 3 [/SUP], Manolis Vavuranakis[SUP] 1 [/SUP], Dimitrios Tousoulis[SUP] 3 [/SUP]
Affiliations
Abstract
Background: Several studies have revealed the link between Coronavirus Disease 2019 (COVID-19) and endothelial dysfunction. To better understand the global pattern of this relationship, we conducted a meta-analysis on endothelial biomarkers related to COVID-19 severity.
Methods: We systematically searched the literature up to March 10, 2021, for studies investigating the association between COVID-19 severity and the following endothelial biomarkers: Intercellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule 1 (VCAM-1), E-selectin, P-selectin, Von Willebrand Factor Antigen (VWF-Ag), soluble Thrombomodulin (sTM), Mid-regional pro-adrenomedullin (MR-proADM), and Angiopoietin-2 (Ang-2). Pooled estimates and mean differences (PMD) for each biomarker were reported.
Results: A total of 27 studies (n=2213 patients) were included. Critically ill patients presented with higher levels of MR-proADM (PMD: 0.71 nmol/L, 95% CI: 0.22 to 1.20 nmol/L, p=0.02), E-selectin (PMD: 13,32 pg/ml, 95% CI: 4,89 to 21,75 pg/ml, p=0.008), VCAM-1 (PMD: 479 ng/ml, 95% CI: 64 to 896 ng/ml, p=0.03), VWF-Ag (PMD: 110.5 IU/dl, 95% CI: 44.8 to 176.1 IU/dl, p=0.04) and Ang-2 (PMD: 2388 pg/ml, 95% CI: 1121 to 3655 pg/ml, p=0.003), as compared to non-critically ill ones. ICAM-1, P-selectin and thrombomodulin did not differ between the two groups (p>0.05).
Conclusion: Endothelial biomarkers display significant heterogeneity in COVID-19 patients, with higher MR-proADM, E-selectin, VCAM-1, VWF-Ag, and Ang-2 levels being associated with increased severity. These findings strengthen the evidence on the key role of endothelial dysfunction in disease progress.
Keywords: COVID-19; SARS-CoV-2; adhesion molecules; biomarkers; disease severity; endothelial dysfunction.
. 2021 Oct 26.
doi: 10.2174/0929867328666211026124033. Online ahead of print.
The Role of Endothelial Related Circulating Biomarkers in COVID-19. A Systematic Review and Meta-analysis
Stamatios Lampsas[SUP] 1 [/SUP], Paraskevas Tsaplaris[SUP] 1 [/SUP], Panteleimon Pantelidis[SUP] 1 [/SUP], Evangelos Oikonomou[SUP] 1 [/SUP], Georgios Marinos[SUP] 2 [/SUP], Georgios Charalambous[SUP] 1 [/SUP], Nektarios Souvaliotis[SUP] 1 [/SUP], Vasiliki-Chara Mystakidi[SUP] 1 [/SUP], Athina Goliopoulou[SUP] 1 [/SUP], Efstratios Katsianos[SUP] 1 [/SUP], Gerasimos Siasos[SUP] 1 [/SUP], Michael-Andrew Vavuranakis[SUP] 1 [/SUP], Costas Tsioufis[SUP] 3 [/SUP], Manolis Vavuranakis[SUP] 1 [/SUP], Dimitrios Tousoulis[SUP] 3 [/SUP]
Affiliations
- PMID: 34702152
- DOI: 10.2174/0929867328666211026124033
Abstract
Background: Several studies have revealed the link between Coronavirus Disease 2019 (COVID-19) and endothelial dysfunction. To better understand the global pattern of this relationship, we conducted a meta-analysis on endothelial biomarkers related to COVID-19 severity.
Methods: We systematically searched the literature up to March 10, 2021, for studies investigating the association between COVID-19 severity and the following endothelial biomarkers: Intercellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule 1 (VCAM-1), E-selectin, P-selectin, Von Willebrand Factor Antigen (VWF-Ag), soluble Thrombomodulin (sTM), Mid-regional pro-adrenomedullin (MR-proADM), and Angiopoietin-2 (Ang-2). Pooled estimates and mean differences (PMD) for each biomarker were reported.
Results: A total of 27 studies (n=2213 patients) were included. Critically ill patients presented with higher levels of MR-proADM (PMD: 0.71 nmol/L, 95% CI: 0.22 to 1.20 nmol/L, p=0.02), E-selectin (PMD: 13,32 pg/ml, 95% CI: 4,89 to 21,75 pg/ml, p=0.008), VCAM-1 (PMD: 479 ng/ml, 95% CI: 64 to 896 ng/ml, p=0.03), VWF-Ag (PMD: 110.5 IU/dl, 95% CI: 44.8 to 176.1 IU/dl, p=0.04) and Ang-2 (PMD: 2388 pg/ml, 95% CI: 1121 to 3655 pg/ml, p=0.003), as compared to non-critically ill ones. ICAM-1, P-selectin and thrombomodulin did not differ between the two groups (p>0.05).
Conclusion: Endothelial biomarkers display significant heterogeneity in COVID-19 patients, with higher MR-proADM, E-selectin, VCAM-1, VWF-Ag, and Ang-2 levels being associated with increased severity. These findings strengthen the evidence on the key role of endothelial dysfunction in disease progress.
Keywords: COVID-19; SARS-CoV-2; adhesion molecules; biomarkers; disease severity; endothelial dysfunction.