tetano
Editor, Senior Moderator
Curr Issues Mol Biol
. 2024 Aug 15;46(8):8890-8902.
doi: 10.3390/cimb46080525. Dysregulated Inflammatory Cytokine Levels May Be Useful Markers in a Better Up-Dated Management of COVID-19
Marco Iuliano[SUP] 1 [/SUP], Roberta Maria Mongiovì[SUP] 2 [/SUP], Alberico Parente[SUP] 3 [/SUP], Blerta Kertusha[SUP] 3 [/SUP], Anna Carraro[SUP] 3 [/SUP], Raffaella Marocco[SUP] 3 [/SUP], Giulia Mancarella[SUP] 3 [/SUP], Cosmo Del Borgo[SUP] 3 [/SUP], Laura Fondaco[SUP] 3 [/SUP], Lorenzo Grimaldi[SUP] 1 [/SUP], Maria Dorrucci[SUP] 4 [/SUP], Miriam Lichtner[SUP] 5 [/SUP], Giorgio Mangino[SUP] 1 [/SUP], Giovanna Romeo[SUP] 1 [/SUP]
Affiliations
Coronavirus disease 2019 (COVID-19) is an infection characterized by the dysregulation of systemic cytokine levels. The measurement of serum levels of inflammatory cyto-/chemokines has been suggested as a tool in the management of COVID-19. The aim of this study is to highlight the significance of measured levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, IL-12(p70), IL-27, interferon (IFN)γ, interferon gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, and tumor necrosis factor (TNF)-α in serum samples from infected and recovered subjects, possibly predictive of severity and/or duration of the disease. Serum samples from healthy (HD), positive at hospital admittance (T0), and recovered subjects (T1, 31-60, or 70-200 days post-negativization) were collected and tested through a bead-based cytometric assay and confirmed through ELISA. IL-10 levels were increased in the T0 group compared to both HD and T1. IL-27 significantly decreased in the 31-60 group. IL-1β significantly increased in the 70-200 day group. TNF-α significantly decreased in T0 compared to HD and in the 31-60 group versus HD. IP-10 significantly increased in T0 compared to HD. These results suggest that IP-10 could represent an early marker of clinical worsening, whereas IL-10 might be indicative of the possible onset of post-COVID-19 long syndrome.
Keywords: IL-10; IP-10; SARS-CoV-2; inflammatory mediators.
. 2024 Aug 15;46(8):8890-8902.
doi: 10.3390/cimb46080525. Dysregulated Inflammatory Cytokine Levels May Be Useful Markers in a Better Up-Dated Management of COVID-19
Marco Iuliano[SUP] 1 [/SUP], Roberta Maria Mongiovì[SUP] 2 [/SUP], Alberico Parente[SUP] 3 [/SUP], Blerta Kertusha[SUP] 3 [/SUP], Anna Carraro[SUP] 3 [/SUP], Raffaella Marocco[SUP] 3 [/SUP], Giulia Mancarella[SUP] 3 [/SUP], Cosmo Del Borgo[SUP] 3 [/SUP], Laura Fondaco[SUP] 3 [/SUP], Lorenzo Grimaldi[SUP] 1 [/SUP], Maria Dorrucci[SUP] 4 [/SUP], Miriam Lichtner[SUP] 5 [/SUP], Giorgio Mangino[SUP] 1 [/SUP], Giovanna Romeo[SUP] 1 [/SUP]
Affiliations
- PMID: 39194742
- DOI: 10.3390/cimb46080525
Coronavirus disease 2019 (COVID-19) is an infection characterized by the dysregulation of systemic cytokine levels. The measurement of serum levels of inflammatory cyto-/chemokines has been suggested as a tool in the management of COVID-19. The aim of this study is to highlight the significance of measured levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, IL-12(p70), IL-27, interferon (IFN)γ, interferon gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, and tumor necrosis factor (TNF)-α in serum samples from infected and recovered subjects, possibly predictive of severity and/or duration of the disease. Serum samples from healthy (HD), positive at hospital admittance (T0), and recovered subjects (T1, 31-60, or 70-200 days post-negativization) were collected and tested through a bead-based cytometric assay and confirmed through ELISA. IL-10 levels were increased in the T0 group compared to both HD and T1. IL-27 significantly decreased in the 31-60 group. IL-1β significantly increased in the 70-200 day group. TNF-α significantly decreased in T0 compared to HD and in the 31-60 group versus HD. IP-10 significantly increased in T0 compared to HD. These results suggest that IP-10 could represent an early marker of clinical worsening, whereas IL-10 might be indicative of the possible onset of post-COVID-19 long syndrome.
Keywords: IL-10; IP-10; SARS-CoV-2; inflammatory mediators.