tetano
Editor, Senior Moderator
Cureus
. 2021 Mar 25;13(3):e14101.
doi: 10.7759/cureus.14101.
Warm Autoimmune Hemolytic Anemia Associated With Asymptomatic SARS-CoV-2 Infection
Joseph R Liput[SUP] 1 [/SUP], Kim Jordan[SUP] 1 [/SUP], Rini Patadia[SUP] 1 [/SUP], Elizabeth Kander[SUP] 2 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resultant coronavirus disease 2019 (COVID-19) are associated with several hematologic abnormalities, including immune thrombocytopenia, antiphospholipid syndrome, and autoimmune hemolytic anemia (AIHA). Initial case reports suggested immune dysregulation to be the underlying etiology of SARS-CoV-2-associated AIHA, as all reported cases involved patients with moderate to severe COVID-19, many of whom had underlying lymphoproliferative disorders. More recently, AIHA has been reported in patients with mildly symptomatic SARS-CoV-2 infection. Here, we detail a patient with asymptomatic SARS-CoV-2 infection who presented with severe, symptomatic anemia. Workup was consistent with warm autoimmune hemolytic anemia (WAIHA) secondary to SARS-CoV-2 infection.
Keywords: anemia; coronavirus disease 2019 (covid-19); severe acute respiratory syndrome coronavirus 2 (sars-cov-2); warm autoimmune hemolytic anemia.
. 2021 Mar 25;13(3):e14101.
doi: 10.7759/cureus.14101.
Warm Autoimmune Hemolytic Anemia Associated With Asymptomatic SARS-CoV-2 Infection
Joseph R Liput[SUP] 1 [/SUP], Kim Jordan[SUP] 1 [/SUP], Rini Patadia[SUP] 1 [/SUP], Elizabeth Kander[SUP] 2 [/SUP]
Affiliations
- PMID: 33927918
- PMCID: PMC8075761
- DOI: 10.7759/cureus.14101
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resultant coronavirus disease 2019 (COVID-19) are associated with several hematologic abnormalities, including immune thrombocytopenia, antiphospholipid syndrome, and autoimmune hemolytic anemia (AIHA). Initial case reports suggested immune dysregulation to be the underlying etiology of SARS-CoV-2-associated AIHA, as all reported cases involved patients with moderate to severe COVID-19, many of whom had underlying lymphoproliferative disorders. More recently, AIHA has been reported in patients with mildly symptomatic SARS-CoV-2 infection. Here, we detail a patient with asymptomatic SARS-CoV-2 infection who presented with severe, symptomatic anemia. Workup was consistent with warm autoimmune hemolytic anemia (WAIHA) secondary to SARS-CoV-2 infection.
Keywords: anemia; coronavirus disease 2019 (covid-19); severe acute respiratory syndrome coronavirus 2 (sars-cov-2); warm autoimmune hemolytic anemia.