tetano
Editor, Senior Moderator
Cureus
. 2021 Jul 4;13(7):e16172.
doi: 10.7759/cureus.16172. eCollection 2021 Jul.
Two Cases of Post-Moderna COVID-19 Vaccine Encephalopathy Associated With Nonconvulsive Status Epilepticus
Benjamin D Liu[SUP] 1 [/SUP], Corrado Ugolini[SUP] 1 [/SUP], Pinky Jha[SUP] 2 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) infections can cause many complications, including central nervous system (CNS) complications. One of the most common COVID-19 CNS complications is COVID-19 encephalopathy, a disorder characterized by cognitive impairment, altered consciousness, and even seizures. The Moderna COVID-19 vaccine is a recently approved mRNA-based vaccine aimed at preventing COVID-19 infections and their complications. Here, we describe two patients with no known neurological or psychiatric history who presented with encephalopathy and seizures that began after part one of their Moderna COVID-19 vaccine series. To our knowledge, there are no other reports of post-Moderna COVID-19 vaccine encephalopathy in the literature. We suggest a mechanism for this complication and thoroughly discuss why the Moderna vaccine is possibly responsible, by addressing confounders in our patients.
Keywords: covid-19; covid-19 vaccine complication; covid-19-related encephalopathy; moderna vaccine encephalopathy; non-convulsive status epilepticus; vaccine seizures.
. 2021 Jul 4;13(7):e16172.
doi: 10.7759/cureus.16172. eCollection 2021 Jul.
Two Cases of Post-Moderna COVID-19 Vaccine Encephalopathy Associated With Nonconvulsive Status Epilepticus
Benjamin D Liu[SUP] 1 [/SUP], Corrado Ugolini[SUP] 1 [/SUP], Pinky Jha[SUP] 2 [/SUP]
Affiliations
- PMID: 34367780
- PMCID: PMC8330960
- DOI: 10.7759/cureus.16172
Abstract
Coronavirus disease 2019 (COVID-19) infections can cause many complications, including central nervous system (CNS) complications. One of the most common COVID-19 CNS complications is COVID-19 encephalopathy, a disorder characterized by cognitive impairment, altered consciousness, and even seizures. The Moderna COVID-19 vaccine is a recently approved mRNA-based vaccine aimed at preventing COVID-19 infections and their complications. Here, we describe two patients with no known neurological or psychiatric history who presented with encephalopathy and seizures that began after part one of their Moderna COVID-19 vaccine series. To our knowledge, there are no other reports of post-Moderna COVID-19 vaccine encephalopathy in the literature. We suggest a mechanism for this complication and thoroughly discuss why the Moderna vaccine is possibly responsible, by addressing confounders in our patients.
Keywords: covid-19; covid-19 vaccine complication; covid-19-related encephalopathy; moderna vaccine encephalopathy; non-convulsive status epilepticus; vaccine seizures.