tetano
Editor, Senior Moderator
Cureus
. 2021 Oct 9;13(10):e18626.
doi: 10.7759/cureus.18626. eCollection 2021 Oct.
Symptomatic Carotid Artery Thrombosis in a Patient Recently Recovered From a COVID-19 Infection
Ilkin Bakirli[SUP] 1 2 [/SUP], Jan Tomka[SUP] 1 2 [/SUP], Marian Pis[SUP] 1 2 [/SUP], Hasan Bakirli[SUP] 3 4 [/SUP], Gultakin Bakirova[SUP] 5 [/SUP], Matej Osusky[SUP] 1 [/SUP], Andrej Gazi[SUP] 1 [/SUP], Ifrat Bakirov[SUP] 6 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), was initially discovered in December 2019 in China and rapidly spread all over the world to become a pandemic. The most common symptoms of a disease are fever, cough, generalized body ache, weakness, dyspnoea, nausea, vomiting, and diarrhea. Among vascular complications of COVID-19, the venous thrombotic complications, like pulmonary embolism and lower limb deep veins thrombosis, are not uncommon. But data about arterial thrombotic complications of COVID-19, especially carotid thrombosis, are still limited. We are describing a case of stroke due to thrombosis of the right carotid arteries, in a patient who had recovered from asymptomatic COVID-19. A 66-year-old male with arterial hypertension presented to the emergency department with a history of repeated collapse, dysarthria, weakness in the left extremities, and a drop in the left angle of his mouth (National Institutes of Health Stroke Scale [NIHSS]-4). The patient was swabbed for COVID-19 which was negative. A computed tomography angiography (CTA) was obtained which showed thrombosis in the branching point of the brachiocephalic trunk (BCT) continuing into the right subclavian artery (SA) and also into the right common carotid artery (CCA), with a subtotal occlusion of the right CCA, extending into the internal carotid artery (ICA) as well. From the apical lung tissue caught during the CT scan, bilateral, irregular widespread ground-glass opacifications, as well as consolidations and small reticular changes were seen in the lungs, which is typical for COVID-19 infection. A quantitative antibody test for COVID-19 infection was performed with the results showing a strong positivity for IgG antibodies, indicating previous COVID-19 infection. The patient was indicated for a standard carotid thrombectomy, which was performed without complications. It seems that one of the important factors that led to the formation of the thrombus in the carotid arteries was COVID-19 infection-induced inflammation in the atherosclerotic carotid vessels and generalized hypercoagulability as well as hyperviscosity. COVID-19 infection is an independent and important risk factor for the formation of an arterial thrombus during the acute illness and in the early post-COVID-19 period also, regardless of the severity of its course. Prophylactic anticoagulation is needed not only at the time of acute illness but also at the early post-COVID-19 time.
Keywords: angiography; anticoagulation; arteriotomy; carotid artery; carotid thrombectomy; covid-19 infection; cytokine storm; ischemic stroke; thrombosis.
. 2021 Oct 9;13(10):e18626.
doi: 10.7759/cureus.18626. eCollection 2021 Oct.
Symptomatic Carotid Artery Thrombosis in a Patient Recently Recovered From a COVID-19 Infection
Ilkin Bakirli[SUP] 1 2 [/SUP], Jan Tomka[SUP] 1 2 [/SUP], Marian Pis[SUP] 1 2 [/SUP], Hasan Bakirli[SUP] 3 4 [/SUP], Gultakin Bakirova[SUP] 5 [/SUP], Matej Osusky[SUP] 1 [/SUP], Andrej Gazi[SUP] 1 [/SUP], Ifrat Bakirov[SUP] 6 [/SUP]
Affiliations
- PMID: 34659924
- PMCID: PMC8502242
- DOI: 10.7759/cureus.18626
Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), was initially discovered in December 2019 in China and rapidly spread all over the world to become a pandemic. The most common symptoms of a disease are fever, cough, generalized body ache, weakness, dyspnoea, nausea, vomiting, and diarrhea. Among vascular complications of COVID-19, the venous thrombotic complications, like pulmonary embolism and lower limb deep veins thrombosis, are not uncommon. But data about arterial thrombotic complications of COVID-19, especially carotid thrombosis, are still limited. We are describing a case of stroke due to thrombosis of the right carotid arteries, in a patient who had recovered from asymptomatic COVID-19. A 66-year-old male with arterial hypertension presented to the emergency department with a history of repeated collapse, dysarthria, weakness in the left extremities, and a drop in the left angle of his mouth (National Institutes of Health Stroke Scale [NIHSS]-4). The patient was swabbed for COVID-19 which was negative. A computed tomography angiography (CTA) was obtained which showed thrombosis in the branching point of the brachiocephalic trunk (BCT) continuing into the right subclavian artery (SA) and also into the right common carotid artery (CCA), with a subtotal occlusion of the right CCA, extending into the internal carotid artery (ICA) as well. From the apical lung tissue caught during the CT scan, bilateral, irregular widespread ground-glass opacifications, as well as consolidations and small reticular changes were seen in the lungs, which is typical for COVID-19 infection. A quantitative antibody test for COVID-19 infection was performed with the results showing a strong positivity for IgG antibodies, indicating previous COVID-19 infection. The patient was indicated for a standard carotid thrombectomy, which was performed without complications. It seems that one of the important factors that led to the formation of the thrombus in the carotid arteries was COVID-19 infection-induced inflammation in the atherosclerotic carotid vessels and generalized hypercoagulability as well as hyperviscosity. COVID-19 infection is an independent and important risk factor for the formation of an arterial thrombus during the acute illness and in the early post-COVID-19 period also, regardless of the severity of its course. Prophylactic anticoagulation is needed not only at the time of acute illness but also at the early post-COVID-19 time.
Keywords: angiography; anticoagulation; arteriotomy; carotid artery; carotid thrombectomy; covid-19 infection; cytokine storm; ischemic stroke; thrombosis.