tetano
Editor, Senior Moderator
Cureus
. 2021 Dec 21;13(12):e20579.
doi: 10.7759/cureus.20579. eCollection 2021 Dec.
Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies Among Healthcare Workers After Vaccine Administration in an Intensive Care Unit
Cláudia Lemos[SUP] 1 [/SUP], Sofia Ferreira[SUP] 1 [/SUP], Cláudio Gouveia[SUP] 2 [/SUP], Érica Mendonça[SUP] 3 [/SUP], Ana Marta Mota[SUP] 1 [/SUP], Mariana Rodrigues[SUP] 4 [/SUP], José Alves[SUP] 3 [/SUP], Susana Chaves[SUP] 1 [/SUP], Graça Andrade[SUP] 3 [/SUP], José J Nóbrega[SUP] 5 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19) emerged in China in December 2019. Healthcare workers (HCWs) are one of the high-risk groups of infection and knowledge of the seroprevalence of SARS-CoV-2 antibodies among this class is very important, not only to understand the spread of COVID-19 among health institutions but also to assess the success of public health interventions. The objective of this prospective study was to determine the seroprevalence of COVID-19 immunoglobulin G (IgG) antibodies after vaccine administration and assess the symptomatology associated with the number of IgG antibodies. A total of 75 HCWs from an intensive care unit were studied three and six months after the second administration of the COVID-19 vaccine. They were divided into three groups: IgG antibodies between 4,160 and 6,350 (group one), greater than 6,350 (group two), and less than 4,160 (group three). After the first administration of the vaccine, 80% had symptoms in both groups one and two, whereas only 13.8% had symptoms in group three. After the second dose of the vaccine, all elements of group one and 80% of group two developed symptoms, but only 40% of group three manifested symptoms. With the exception of one, all professionals showed a decrease in the number of IgG antibodies from three to six months. Our findings show that professionals with a higher number of IgG antibodies had more symptoms and that these rapidly declined over the three-to-six-month period.
Keywords: covid-19; healthcare workers; immunoglobulin g; sars-cov-2 antibody response; vaccine.
. 2021 Dec 21;13(12):e20579.
doi: 10.7759/cureus.20579. eCollection 2021 Dec.
Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies Among Healthcare Workers After Vaccine Administration in an Intensive Care Unit
Cláudia Lemos[SUP] 1 [/SUP], Sofia Ferreira[SUP] 1 [/SUP], Cláudio Gouveia[SUP] 2 [/SUP], Érica Mendonça[SUP] 3 [/SUP], Ana Marta Mota[SUP] 1 [/SUP], Mariana Rodrigues[SUP] 4 [/SUP], José Alves[SUP] 3 [/SUP], Susana Chaves[SUP] 1 [/SUP], Graça Andrade[SUP] 3 [/SUP], José J Nóbrega[SUP] 5 [/SUP]
Affiliations
- PMID: 34963873
- PMCID: PMC8695690
- DOI: 10.7759/cureus.20579
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19) emerged in China in December 2019. Healthcare workers (HCWs) are one of the high-risk groups of infection and knowledge of the seroprevalence of SARS-CoV-2 antibodies among this class is very important, not only to understand the spread of COVID-19 among health institutions but also to assess the success of public health interventions. The objective of this prospective study was to determine the seroprevalence of COVID-19 immunoglobulin G (IgG) antibodies after vaccine administration and assess the symptomatology associated with the number of IgG antibodies. A total of 75 HCWs from an intensive care unit were studied three and six months after the second administration of the COVID-19 vaccine. They were divided into three groups: IgG antibodies between 4,160 and 6,350 (group one), greater than 6,350 (group two), and less than 4,160 (group three). After the first administration of the vaccine, 80% had symptoms in both groups one and two, whereas only 13.8% had symptoms in group three. After the second dose of the vaccine, all elements of group one and 80% of group two developed symptoms, but only 40% of group three manifested symptoms. With the exception of one, all professionals showed a decrease in the number of IgG antibodies from three to six months. Our findings show that professionals with a higher number of IgG antibodies had more symptoms and that these rapidly declined over the three-to-six-month period.
Keywords: covid-19; healthcare workers; immunoglobulin g; sars-cov-2 antibody response; vaccine.
