tetano
Editor, Senior Moderator
Cureus
. 2023 Jan 20;15(1):e34004.
doi: 10.7759/cureus.34004. eCollection 2023 Jan.
Risk of COVID-19 Infection After Full Immunization in Patients With Inflammatory Bowel Disease on Treatment: A Research Network Analysis
Julton Tomanguillo[SUP] 1 [/SUP], Lauren Searls[SUP] 1 [/SUP], Frank H Annie[SUP] 2 [/SUP], Suzanne Kemper[SUP] 3 [/SUP], Vishnu Naravadi[SUP] 4 [/SUP]
Affiliations
Abstract
Background: Acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an issue in treating patients with Inflammatory Bowel Disease (IBD) due to concerns for infection risk and poor post-vaccination antibody response. We examined the potential impact of IBD treatments on SARS-CoV-2 infection rates after full immunization against COVID-19.
Methods: Patients who received vaccines between January 2020 and July 2021 were identified. The post-immunization Covid-19 infection rate at 3 and 6 months was assessed in IBD patients receiving treatment. The infection rates were compared to patients without IBD. Results: The total number of IBD patients was 143,248; of those (n=9405), 6.6% were fully vaccinated. In IBD patients taking biologic agents/small molecules, no difference in Covid-19 infection rate was found at 3 (1.3% vs. 0.97%, p=0.30) and 6 months (2.2% vs. 1.7%, p=0.19) when compared to non-IBD patients. No significant difference in Covid-19 infection rate was found among patients receiving systemic steroids at 3 (1.6% vs. 1.6%, p=1) and 6 months (2.6% vs. 2.9%, p=0.50) between the IBD and non-IBD cohorts. Conclusions: The COVID-19 immunization rate is suboptimal among IBD patients (6.6%). Vaccination in this cohort is under-utilized and should be encouraged by all healthcare providers.
Keywords: biologic/small molecule; ibd; sars-cov2; steroids; us food and drug administration.
. 2023 Jan 20;15(1):e34004.
doi: 10.7759/cureus.34004. eCollection 2023 Jan.
Risk of COVID-19 Infection After Full Immunization in Patients With Inflammatory Bowel Disease on Treatment: A Research Network Analysis
Julton Tomanguillo[SUP] 1 [/SUP], Lauren Searls[SUP] 1 [/SUP], Frank H Annie[SUP] 2 [/SUP], Suzanne Kemper[SUP] 3 [/SUP], Vishnu Naravadi[SUP] 4 [/SUP]
Affiliations
- PMID: 36811056
- PMCID: PMC9939048
- DOI: 10.7759/cureus.34004
Abstract
Background: Acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an issue in treating patients with Inflammatory Bowel Disease (IBD) due to concerns for infection risk and poor post-vaccination antibody response. We examined the potential impact of IBD treatments on SARS-CoV-2 infection rates after full immunization against COVID-19.
Methods: Patients who received vaccines between January 2020 and July 2021 were identified. The post-immunization Covid-19 infection rate at 3 and 6 months was assessed in IBD patients receiving treatment. The infection rates were compared to patients without IBD. Results: The total number of IBD patients was 143,248; of those (n=9405), 6.6% were fully vaccinated. In IBD patients taking biologic agents/small molecules, no difference in Covid-19 infection rate was found at 3 (1.3% vs. 0.97%, p=0.30) and 6 months (2.2% vs. 1.7%, p=0.19) when compared to non-IBD patients. No significant difference in Covid-19 infection rate was found among patients receiving systemic steroids at 3 (1.6% vs. 1.6%, p=1) and 6 months (2.6% vs. 2.9%, p=0.50) between the IBD and non-IBD cohorts. Conclusions: The COVID-19 immunization rate is suboptimal among IBD patients (6.6%). Vaccination in this cohort is under-utilized and should be encouraged by all healthcare providers.
Keywords: biologic/small molecule; ibd; sars-cov2; steroids; us food and drug administration.