tetano
Editor, Senior Moderator
Cureus
. 2023 Apr 18;15(4):e37767.
doi: 10.7759/cureus.37767. eCollection 2023 Apr. Rapidly Progressive Glomerulonephritis: A COVID-19 Case Report
Ali Tahir[SUP] 1 [/SUP], Jasmit Walia[SUP] 1 [/SUP], Timothy Daly[SUP] 1 [/SUP], Alexandra Gradzka[SUP] 1 [/SUP], Ruslan Banai[SUP] 1 [/SUP]
Affiliations
Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis is a systemic autoimmune disease that typically presents as a multi-organ manifesting disease of unclear etiology that can predispose to rapidly progressive glomerulonephritis (RPGN). If left untreated, ANCA-associated vasculitis can be fatal, and RPGN can progress to irreversible renal failure. Environmental and genetic factors have been implicated in the pathogenesis of this vasculitis. Coronavirus disease (COVID-19) has been noted to have various physiologic impacts on the body, with literature indicating possible autoimmune effects. We present a rare case of ANCA-associated vasculitis in an elderly male with no known autoimmune history after a recent illness with COVID-19. The patient had been seen as an outpatient with progressively declining renal function until he presented to the hospital with acute renal failure and pericarditis. Workup revealed elevated anti-myeloperoxidase antibody (MPO-AB) and perinuclear ANCA (p-ANCA) antibodies with a biopsy confirming focal cresenteric glomerulonephritis, and the patient was initiated on steroid therapy with notable improvement and a return to baseline kidney function.
Keywords: antineutrophil cytoplasmic antibody (anca) associated vasculitis (aav); covid 19; pauci-immune glomerulonephritis (gn); pericarditis; rapidly progressive renal failure; renal failure.
. 2023 Apr 18;15(4):e37767.
doi: 10.7759/cureus.37767. eCollection 2023 Apr. Rapidly Progressive Glomerulonephritis: A COVID-19 Case Report
Ali Tahir[SUP] 1 [/SUP], Jasmit Walia[SUP] 1 [/SUP], Timothy Daly[SUP] 1 [/SUP], Alexandra Gradzka[SUP] 1 [/SUP], Ruslan Banai[SUP] 1 [/SUP]
Affiliations
- PMID: 37214004
- PMCID: PMC10194189
- DOI: 10.7759/cureus.37767
Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis is a systemic autoimmune disease that typically presents as a multi-organ manifesting disease of unclear etiology that can predispose to rapidly progressive glomerulonephritis (RPGN). If left untreated, ANCA-associated vasculitis can be fatal, and RPGN can progress to irreversible renal failure. Environmental and genetic factors have been implicated in the pathogenesis of this vasculitis. Coronavirus disease (COVID-19) has been noted to have various physiologic impacts on the body, with literature indicating possible autoimmune effects. We present a rare case of ANCA-associated vasculitis in an elderly male with no known autoimmune history after a recent illness with COVID-19. The patient had been seen as an outpatient with progressively declining renal function until he presented to the hospital with acute renal failure and pericarditis. Workup revealed elevated anti-myeloperoxidase antibody (MPO-AB) and perinuclear ANCA (p-ANCA) antibodies with a biopsy confirming focal cresenteric glomerulonephritis, and the patient was initiated on steroid therapy with notable improvement and a return to baseline kidney function.
Keywords: antineutrophil cytoplasmic antibody (anca) associated vasculitis (aav); covid 19; pauci-immune glomerulonephritis (gn); pericarditis; rapidly progressive renal failure; renal failure.