tetano
Editor, Senior Moderator
Cureus
. 2020 Jun 29;12(6):e8915.
doi: 10.7759/cureus.8915.
Pediatric Case of Severe COVID-19 With Shock and Multisystem Inflammation
David C Nguyen[SUP] 1 [/SUP], Hanan Haydar[SUP] 1 [/SUP], Elizabeth R Pace[SUP] 2 [/SUP], Xiaochun Susan Zhang[SUP] 3 [/SUP], Katherine R Dobbs[SUP] 1 4 [/SUP]
Affiliations
Abstract
While the majority of pediatric coronavirus disease 2019 (COVID-19) cases have not been critical, occurrences of a multisystem inflammatory syndrome in children (MIS-C) have been emerging as the pandemic progresses. Herein, we report our experience with a pediatric COVID-19 case that presented with shock and multisystem inflammation. Our patient notably had multiple negative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) assays but tested positive for SARS-CoV-2 IgG antibody. This case not only highlights the utility of SARS-CoV-2 IgG in the diagnosis of COVID-19 when RT-PCR is negative but suggests MIS-C may be a post-infectious immune-mediated process.
Keywords: covid-19; inflammation; mis-c; multisystem; pediatric; sars-cov-2.
. 2020 Jun 29;12(6):e8915.
doi: 10.7759/cureus.8915.
Pediatric Case of Severe COVID-19 With Shock and Multisystem Inflammation
David C Nguyen[SUP] 1 [/SUP], Hanan Haydar[SUP] 1 [/SUP], Elizabeth R Pace[SUP] 2 [/SUP], Xiaochun Susan Zhang[SUP] 3 [/SUP], Katherine R Dobbs[SUP] 1 4 [/SUP]
Affiliations
- PMID: 32742881
- PMCID: PMC7389873
- DOI: 10.7759/cureus.8915
Abstract
While the majority of pediatric coronavirus disease 2019 (COVID-19) cases have not been critical, occurrences of a multisystem inflammatory syndrome in children (MIS-C) have been emerging as the pandemic progresses. Herein, we report our experience with a pediatric COVID-19 case that presented with shock and multisystem inflammation. Our patient notably had multiple negative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) assays but tested positive for SARS-CoV-2 IgG antibody. This case not only highlights the utility of SARS-CoV-2 IgG in the diagnosis of COVID-19 when RT-PCR is negative but suggests MIS-C may be a post-infectious immune-mediated process.
Keywords: covid-19; inflammation; mis-c; multisystem; pediatric; sars-cov-2.