tetano
Editor, Senior Moderator
Cureus
. 2021 Jun 15;13(6):e15664.
doi: 10.7759/cureus.15664. eCollection 2021 Jun.
New-Onset Neurologic Symptoms and Related Neuro-Oncologic Lesions Discovered After COVID-19 Vaccination: Two Neurosurgical Cases and Review of Post-Vaccine Inflammatory Responses
Evan H Einstein[SUP] 1 [/SUP], Andia Shahzadi[SUP] 1 [/SUP], Likowsky Desir[SUP] 1 [/SUP], Joshua Katz[SUP] 1 [/SUP], John Boockvar[SUP] 1 [/SUP], Randy D'Amico[SUP] 1 [/SUP]
Affiliations
Abstract
A global effort is underway to distribute coronavirus disease 2019 (COVID-19) vaccines to limit the crisis. Although adverse events related to vaccination are rare, there have been cases of new-onset neurologic symptoms following vaccination. We present two cases of new-onset neurologic symptoms post-vaccination that, upon further workup, revealed two different neuro-oncologic processes requiring neurosurgical intervention and further treatment. We hypothesize that despite these processes being unrelated to vaccination, the COVID-19 vaccines may induce an inflammatory cascade with the ability to uncover underlying sinister pathology. Our report therefore emphasizes the need for careful evaluation in the setting of new-onset neurologic symptoms after COVID-19 vaccination.
Keywords: covid-19 vaccine; glioma; inflammation; melanoma; neurological symptoms.
. 2021 Jun 15;13(6):e15664.
doi: 10.7759/cureus.15664. eCollection 2021 Jun.
New-Onset Neurologic Symptoms and Related Neuro-Oncologic Lesions Discovered After COVID-19 Vaccination: Two Neurosurgical Cases and Review of Post-Vaccine Inflammatory Responses
Evan H Einstein[SUP] 1 [/SUP], Andia Shahzadi[SUP] 1 [/SUP], Likowsky Desir[SUP] 1 [/SUP], Joshua Katz[SUP] 1 [/SUP], John Boockvar[SUP] 1 [/SUP], Randy D'Amico[SUP] 1 [/SUP]
Affiliations
- PMID: 34277256
- PMCID: PMC8281785
- DOI: 10.7759/cureus.15664
Abstract
A global effort is underway to distribute coronavirus disease 2019 (COVID-19) vaccines to limit the crisis. Although adverse events related to vaccination are rare, there have been cases of new-onset neurologic symptoms following vaccination. We present two cases of new-onset neurologic symptoms post-vaccination that, upon further workup, revealed two different neuro-oncologic processes requiring neurosurgical intervention and further treatment. We hypothesize that despite these processes being unrelated to vaccination, the COVID-19 vaccines may induce an inflammatory cascade with the ability to uncover underlying sinister pathology. Our report therefore emphasizes the need for careful evaluation in the setting of new-onset neurologic symptoms after COVID-19 vaccination.
Keywords: covid-19 vaccine; glioma; inflammation; melanoma; neurological symptoms.