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Cureus . Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis Following SARS-CoV-2 Vaccination

tetano

tetano

Editor, Senior Moderator
Cureus


. 2025 Jan 31;17(1):e78286.
doi: 10.7759/cureus.78286. eCollection 2025 Jan. Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis Following SARS-CoV-2 Vaccination

Bruna Cunha[SUP] 1 [/SUP], Pedro Gil[SUP] 1 [/SUP], Afonso Murta[SUP] 1 [/SUP], Diogo Hipólito-Fernandes[SUP] 1 [/SUP], Lívio Costa[SUP] 1 [/SUP]



Affiliations
Abstract

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune demyelinating disorder that occurs in approximately 20% of cases in a postinfectious or postvaccination context. To date, few cases of MOGAD have been reported following SARS-CoV-2 immunization. Here, we report the case of a 28-year-old female presenting with isolated unilateral optic neuritis, achieving complete recovery after corticosteroid treatment. To the best of our knowledge, this represents the second reported case of MOGAD following the mRNA-1273 vaccine and the first presenting as isolated and unilateral optic neuritis.

Keywords: coronavirus vaccination; moderna mrna1273; mog-igg-associated optic neuritis; sars-cov-2; unilateral optic neuritis.

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