tetano
Editor, Senior Moderator
Cureus
. 2022 Jan 18;14(1):e21374.
doi: 10.7759/cureus.21374. eCollection 2022 Jan.
Multiple Sclerosis Relapse Following COVID-19 Vaccination: A Case Report and Literature Review
Saurabh Kataria[SUP] 1 2 3 [/SUP], Sylvette Rogers[SUP] 4 [/SUP], Usama Bilal[SUP] 5 [/SUP], Haisum Baktashi[SUP] 6 [/SUP], Romil Singh[SUP] 7 [/SUP]
Affiliations
Abstract
Mass vaccination against coronavirus disease 19 (COVID-19) has effectively controlled the pandemic and has been remarkably effective and safe. Reports of a few adverse events have been reported after post-marketing surveillance. We present a rare case of multiple sclerosis (MS) relapse in a female who presented with fatigue, involuntary eye movements, and numbness; autoimmunity following the COVID-19 vaccine has also been described. She was diagnosed with MS six years back and was in remission. She received her COVID-19 vaccine 18 days ago. Her clinical and radiological features confirmed the MS relapse. Her serology for COVID-19 immunoglobulin G (IgG) and IgM was positive, and she was managed with intravenous methylprednisolone and symptomatic management. Our case provides a possible association of vaccine-associated MS relapse; however, more evidence is warranted from future studies.
Keywords: covid-19 vaccine; mrna-based vaccine; multiple sclerosis; multiple sclerosis flare-up; sars-cov-2 pandemic.
. 2022 Jan 18;14(1):e21374.
doi: 10.7759/cureus.21374. eCollection 2022 Jan.
Multiple Sclerosis Relapse Following COVID-19 Vaccination: A Case Report and Literature Review
Saurabh Kataria[SUP] 1 2 3 [/SUP], Sylvette Rogers[SUP] 4 [/SUP], Usama Bilal[SUP] 5 [/SUP], Haisum Baktashi[SUP] 6 [/SUP], Romil Singh[SUP] 7 [/SUP]
Affiliations
- PMID: 35198286
- PMCID: PMC8854205
- DOI: 10.7759/cureus.21374
Abstract
Mass vaccination against coronavirus disease 19 (COVID-19) has effectively controlled the pandemic and has been remarkably effective and safe. Reports of a few adverse events have been reported after post-marketing surveillance. We present a rare case of multiple sclerosis (MS) relapse in a female who presented with fatigue, involuntary eye movements, and numbness; autoimmunity following the COVID-19 vaccine has also been described. She was diagnosed with MS six years back and was in remission. She received her COVID-19 vaccine 18 days ago. Her clinical and radiological features confirmed the MS relapse. Her serology for COVID-19 immunoglobulin G (IgG) and IgM was positive, and she was managed with intravenous methylprednisolone and symptomatic management. Our case provides a possible association of vaccine-associated MS relapse; however, more evidence is warranted from future studies.
Keywords: covid-19 vaccine; mrna-based vaccine; multiple sclerosis; multiple sclerosis flare-up; sars-cov-2 pandemic.