tetano
Editor, Senior Moderator
Cureus
. 2022 Jan 6;14(1):e20980.
doi: 10.7759/cureus.20980. eCollection 2022 Jan.
Molecular Modeling and Preliminary Clinical Data Suggesting Antiviral Activity for Chlorpheniramine (Chlorphenamine) Against COVID-19
Shaun D Black[SUP] 1 [/SUP]
Affiliations
Abstract
Chlorpheniramine maleate, a widely used over-the-counter antihistamine, has been identified as a structural analog of aminoquinolines known to possess antiviral activity against the Betacoronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19). Structural similarities include the chlorophenyl group, pyridine ring, alkyl sidechain, and terminal tertiary amine; the comparison of aqueous energy-minimized structures indicates significant three-dimensional similarity as well. Preliminary clinical evidence supports these conclusions. The present study suggests that chlorpheniramine possesses antiviral activity against COVID-19.
Keywords: antiviral agents; chlorpheniramine maleate; clinical findings; covid-19; molecular modeling; sars-cov-2.
. 2022 Jan 6;14(1):e20980.
doi: 10.7759/cureus.20980. eCollection 2022 Jan.
Molecular Modeling and Preliminary Clinical Data Suggesting Antiviral Activity for Chlorpheniramine (Chlorphenamine) Against COVID-19
Shaun D Black[SUP] 1 [/SUP]
Affiliations
- PMID: 35154957
- PMCID: PMC8820487
- DOI: 10.7759/cureus.20980
Abstract
Chlorpheniramine maleate, a widely used over-the-counter antihistamine, has been identified as a structural analog of aminoquinolines known to possess antiviral activity against the Betacoronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19). Structural similarities include the chlorophenyl group, pyridine ring, alkyl sidechain, and terminal tertiary amine; the comparison of aqueous energy-minimized structures indicates significant three-dimensional similarity as well. Preliminary clinical evidence supports these conclusions. The present study suggests that chlorpheniramine possesses antiviral activity against COVID-19.
Keywords: antiviral agents; chlorpheniramine maleate; clinical findings; covid-19; molecular modeling; sars-cov-2.