tetano
Editor, Senior Moderator
Cureus
. 2022 Jul 3;14(7):e26540.
doi: 10.7759/cureus.26540. eCollection 2022 Jul.
Kikuchi-Fujimoto Disease Following COVID-19 Infection in a 7-Year-Old Girl: A Case Report and Literature Review
Yusuke Saito[SUP] 1 [/SUP], Yuta Suwa[SUP] 1 [/SUP], Yakuto Kaneko[SUP] 2 [/SUP], Mitsuhiro Tsujiwaki[SUP] 3 [/SUP], Yasuhisa Odagawa[SUP] 1 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) symptoms in children are relatively mild and often do not require treatment. Nonetheless, complications caused by the immune response to COVID-19 in children are possible and diverse. We present the case of a 7-year-old girl with persistent fever and lymphadenopathy arising from SARS-CoV-2 infection, diagnosed with Kikuchi-Fujimoto Disease (KFD) on lymph node biopsy. KFD is a rare benign disease, clinically characterized by fever and tender cervical lymphadenopathy affecting posterior cervical lymph nodes. We also reviewed six previously reported cases of COVID-19-associated KFD that occurred in school-aged children and compared them with the present case. The clinical course of COVID-19-associated KFD was similar to that of previous reports of KFD with a favorable prognosis. This is the first report of a school-aged child developing KFD following SARS-CoV-2 infection. KFD should be considered when approaching patients with hyperinflammatory states who present with prolonged fever and cervical lymphadenopathy after COVID-19.
Keywords: cervical lymphadenopathy; covid-19; histiocytic necrotizing lymphadenitis; kikuchi-fujimoto disease; sars-cov-2.
. 2022 Jul 3;14(7):e26540.
doi: 10.7759/cureus.26540. eCollection 2022 Jul.
Kikuchi-Fujimoto Disease Following COVID-19 Infection in a 7-Year-Old Girl: A Case Report and Literature Review
Yusuke Saito[SUP] 1 [/SUP], Yuta Suwa[SUP] 1 [/SUP], Yakuto Kaneko[SUP] 2 [/SUP], Mitsuhiro Tsujiwaki[SUP] 3 [/SUP], Yasuhisa Odagawa[SUP] 1 [/SUP]
Affiliations
- PMID: 35936128
- PMCID: PMC9351715
- DOI: 10.7759/cureus.26540
Abstract
The coronavirus disease 2019 (COVID-19) symptoms in children are relatively mild and often do not require treatment. Nonetheless, complications caused by the immune response to COVID-19 in children are possible and diverse. We present the case of a 7-year-old girl with persistent fever and lymphadenopathy arising from SARS-CoV-2 infection, diagnosed with Kikuchi-Fujimoto Disease (KFD) on lymph node biopsy. KFD is a rare benign disease, clinically characterized by fever and tender cervical lymphadenopathy affecting posterior cervical lymph nodes. We also reviewed six previously reported cases of COVID-19-associated KFD that occurred in school-aged children and compared them with the present case. The clinical course of COVID-19-associated KFD was similar to that of previous reports of KFD with a favorable prognosis. This is the first report of a school-aged child developing KFD following SARS-CoV-2 infection. KFD should be considered when approaching patients with hyperinflammatory states who present with prolonged fever and cervical lymphadenopathy after COVID-19.
Keywords: cervical lymphadenopathy; covid-19; histiocytic necrotizing lymphadenitis; kikuchi-fujimoto disease; sars-cov-2.