tetano
Editor, Senior Moderator
Cureus
. 2022 Nov 28;14(11):e31982.
doi: 10.7759/cureus.31982. eCollection 2022 Nov.
Investigation of Serum Ferritin for the Prediction of COVID-19 Severity and Mortality: A Cross-Sectional Study
Jihad M Hadi[SUP] 1 2 [/SUP], Hawar M Mohammad[SUP] 2 [/SUP], Ako Y Ahmed[SUP] 1 [/SUP], Shko S Tofiq[SUP] 1 [/SUP], Las B Abdalrahman[SUP] 1 [/SUP], Awin A Qasm[SUP] 1 [/SUP], Ali M Ameer[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Acute respiratory failure develops quickly in patients with a severe form of coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome Coronavirus 2 (SARS‑CoV‑2). Despite being commonly acknowledged as a measure of the body's overall iron storage, ferritin's predictive value is associated with COVID-19.
Objective: This study aimed to evaluate the relationship between COVID-19 and serum ferritin levels as the biochemical markers of SARS-CoV-2 infection in Sulaymaniyah, Iraq.
Method: A biochemical test was performed at Baxshin Hospital in the period from February 2022 to April 2022. It was performed on a total of 85 patients (63.53% males and 36.47% females), ranging in age from 25 to 79 years old, with an average age of 48.4 years old. The patient's blood samples were taken to screen for ferritin levels.
Result: The resulting outcome of this work is high serum ferritin levels for the majority of infected patients. Overall, there is a significant difference between male and female serum ferritin observed with a p-value < 0.05. The median interquartile range (IQR) of serum ferritin was 896 ng/mL for males, while it was only 611 ng/mL for females. The current study showed that age level has a great effect on elevated ferritin levels. It has been discovered that gender impacts increasing ferritin levels; 62% were found to be men and 38% were found to be women, with average ferritin levels of 1111 ng/mL and 712.8 ng/mL, respectively.
Conclusion: SARS-CoV-2 infection causes significant laboratory abnormalities, including a high level of serum ferritin.
Keywords: coronavirus; covid-19; inflammatory markers; sars-cov-2; serum ferritin.
. 2022 Nov 28;14(11):e31982.
doi: 10.7759/cureus.31982. eCollection 2022 Nov.
Investigation of Serum Ferritin for the Prediction of COVID-19 Severity and Mortality: A Cross-Sectional Study
Jihad M Hadi[SUP] 1 2 [/SUP], Hawar M Mohammad[SUP] 2 [/SUP], Ako Y Ahmed[SUP] 1 [/SUP], Shko S Tofiq[SUP] 1 [/SUP], Las B Abdalrahman[SUP] 1 [/SUP], Awin A Qasm[SUP] 1 [/SUP], Ali M Ameer[SUP] 1 [/SUP]
Affiliations
- PMID: 36589200
- PMCID: PMC9797152
- DOI: 10.7759/cureus.31982
Abstract
Background: Acute respiratory failure develops quickly in patients with a severe form of coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome Coronavirus 2 (SARS‑CoV‑2). Despite being commonly acknowledged as a measure of the body's overall iron storage, ferritin's predictive value is associated with COVID-19.
Objective: This study aimed to evaluate the relationship between COVID-19 and serum ferritin levels as the biochemical markers of SARS-CoV-2 infection in Sulaymaniyah, Iraq.
Method: A biochemical test was performed at Baxshin Hospital in the period from February 2022 to April 2022. It was performed on a total of 85 patients (63.53% males and 36.47% females), ranging in age from 25 to 79 years old, with an average age of 48.4 years old. The patient's blood samples were taken to screen for ferritin levels.
Result: The resulting outcome of this work is high serum ferritin levels for the majority of infected patients. Overall, there is a significant difference between male and female serum ferritin observed with a p-value < 0.05. The median interquartile range (IQR) of serum ferritin was 896 ng/mL for males, while it was only 611 ng/mL for females. The current study showed that age level has a great effect on elevated ferritin levels. It has been discovered that gender impacts increasing ferritin levels; 62% were found to be men and 38% were found to be women, with average ferritin levels of 1111 ng/mL and 712.8 ng/mL, respectively.
Conclusion: SARS-CoV-2 infection causes significant laboratory abnormalities, including a high level of serum ferritin.
Keywords: coronavirus; covid-19; inflammatory markers; sars-cov-2; serum ferritin.