tetano
Editor, Senior Moderator
Cureus
. 2023 Jan 28;15(1):e34307.
doi: 10.7759/cureus.34307. eCollection 2023 Jan.
Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection
Guarina Molina[SUP] 1 [/SUP], Rafael Contreras[SUP] 1 [/SUP], Kyle Coombes[SUP] 2 [/SUP], Thilini Walgamage[SUP] 1 [/SUP], Maria A Perozo[SUP] 1 [/SUP], Martha T DesBiens[SUP] 3 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with multiple inflammatory symptoms involving several organ systems, including hematologic manifestations. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome caused by excessive inflammation in the absence of immune regulation. We present the case of a patient with HLH secondary to dysregulated inflammatory response following COVID-19; we also describe the diagnostic and management challenges associated with the condition.
Keywords: covid 19; disseminated intravascular coagulation (dic); hemophagocytic lymphohistiocytosis (hlh); inflammatory mediators; pancytopenia; soluble interleukin receptors.
. 2023 Jan 28;15(1):e34307.
doi: 10.7759/cureus.34307. eCollection 2023 Jan.
Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection
Guarina Molina[SUP] 1 [/SUP], Rafael Contreras[SUP] 1 [/SUP], Kyle Coombes[SUP] 2 [/SUP], Thilini Walgamage[SUP] 1 [/SUP], Maria A Perozo[SUP] 1 [/SUP], Martha T DesBiens[SUP] 3 [/SUP]
Affiliations
- PMID: 36721708
- PMCID: PMC9884115
- DOI: 10.7759/cureus.34307
Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with multiple inflammatory symptoms involving several organ systems, including hematologic manifestations. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome caused by excessive inflammation in the absence of immune regulation. We present the case of a patient with HLH secondary to dysregulated inflammatory response following COVID-19; we also describe the diagnostic and management challenges associated with the condition.
Keywords: covid 19; disseminated intravascular coagulation (dic); hemophagocytic lymphohistiocytosis (hlh); inflammatory mediators; pancytopenia; soluble interleukin receptors.