tetano
Editor, Senior Moderator
Cureus
. 2022 Jun 1;14(6):e25571.
doi: 10.7759/cureus.25571. eCollection 2022 Jun.
Hearing Outcomes of Infants Born to Mothers With Active COVID-19 Infection
Panagiota Kosmidou[SUP] 1 2 [/SUP], Ioannis Karamatzanis[SUP] 3 [/SUP], Sotiris Tzifas[SUP] 4 [/SUP], Aggeliki Vervenioti[SUP] 5 [/SUP], Despoina Gkentzi[SUP] 6 [/SUP], Gabriel Dimitriou[SUP] 7 [/SUP]
Affiliations
Abstract
Introduction COVID-19, caused by SARS-CoV-2, is a highly contagious respiratory tract infection. A major concern of SARS-CoV-2 infection in pregnant women is vertical maternal-fetal transmission and the ramifications on infant hearing. This retrospective study aims to investigate whether perinatal exposure to SARS-CoV-2 has an impact on the hearing of the offspring. Materials The study population included neonates born to unvaccinated COVID-19 positive mothers in the University Hospital of Patras, Greece from March 2020 to January 2021. Polymerase chain reaction (PCR) tests were performed on the neonates on the first, second,[SUP],[/SUP] and seventh day of life. All neonates underwent transient evoked otoacoustic emissions (TEOAEs) within the first three months of life and were all examined at the age of nine months. Results Thirty-two neonates (21 male) were born within the study period and all were transferred to the Neonatal Intensive Care Unit (NICU). Their mean (SD) gestational age was 36.9 (+2.23) weeks and their birth weight was 2,943 (+537) g. Nine of them were preterm and six of them had a low birth weight. Apgar scores calculated at 1' and 5', were in the normal range for 31 (97%) out of 32 neonates. One infant required urgent intubation at birth with an Apgar score of 1' 3 and 5' 4. Four neonates required mechanical ventilatory support, two neonates required nasal CPAP and eight neonates required supplementary oxygen. All infants were negative for TORCH infections. PCR tests were performed within the first day of life and repeated at 48 hours and on the seventh day of life. All PCR tests came back negative. Out of 32 neonates, seven failed the TEOAE test and were tested again a month later with a positive outcome. At nine months of follow-up, all 32 infants passed the TEOAE test. Conclusion In conclusion, in our study, there was no evidence of vertical transmission of SARS-CoV-2 from mothers infected during the third trimester or hearing impairment of the offspring.
Keywords: coronavirus vertical transmission; covid 19; newborn hearing screening; pediatric hearing loss; transient evoked otoacoustic emissions.
. 2022 Jun 1;14(6):e25571.
doi: 10.7759/cureus.25571. eCollection 2022 Jun.
Hearing Outcomes of Infants Born to Mothers With Active COVID-19 Infection
Panagiota Kosmidou[SUP] 1 2 [/SUP], Ioannis Karamatzanis[SUP] 3 [/SUP], Sotiris Tzifas[SUP] 4 [/SUP], Aggeliki Vervenioti[SUP] 5 [/SUP], Despoina Gkentzi[SUP] 6 [/SUP], Gabriel Dimitriou[SUP] 7 [/SUP]
Affiliations
- PMID: 35784961
- PMCID: PMC9249119
- DOI: 10.7759/cureus.25571
Abstract
Introduction COVID-19, caused by SARS-CoV-2, is a highly contagious respiratory tract infection. A major concern of SARS-CoV-2 infection in pregnant women is vertical maternal-fetal transmission and the ramifications on infant hearing. This retrospective study aims to investigate whether perinatal exposure to SARS-CoV-2 has an impact on the hearing of the offspring. Materials The study population included neonates born to unvaccinated COVID-19 positive mothers in the University Hospital of Patras, Greece from March 2020 to January 2021. Polymerase chain reaction (PCR) tests were performed on the neonates on the first, second,[SUP],[/SUP] and seventh day of life. All neonates underwent transient evoked otoacoustic emissions (TEOAEs) within the first three months of life and were all examined at the age of nine months. Results Thirty-two neonates (21 male) were born within the study period and all were transferred to the Neonatal Intensive Care Unit (NICU). Their mean (SD) gestational age was 36.9 (+2.23) weeks and their birth weight was 2,943 (+537) g. Nine of them were preterm and six of them had a low birth weight. Apgar scores calculated at 1' and 5', were in the normal range for 31 (97%) out of 32 neonates. One infant required urgent intubation at birth with an Apgar score of 1' 3 and 5' 4. Four neonates required mechanical ventilatory support, two neonates required nasal CPAP and eight neonates required supplementary oxygen. All infants were negative for TORCH infections. PCR tests were performed within the first day of life and repeated at 48 hours and on the seventh day of life. All PCR tests came back negative. Out of 32 neonates, seven failed the TEOAE test and were tested again a month later with a positive outcome. At nine months of follow-up, all 32 infants passed the TEOAE test. Conclusion In conclusion, in our study, there was no evidence of vertical transmission of SARS-CoV-2 from mothers infected during the third trimester or hearing impairment of the offspring.
Keywords: coronavirus vertical transmission; covid 19; newborn hearing screening; pediatric hearing loss; transient evoked otoacoustic emissions.