tetano
Editor, Senior Moderator
Cureus
. 2021 Nov 11;13(11):e19481.
doi: 10.7759/cureus.19481. eCollection 2021 Nov.
Delayed Immune Reconstitution Inflammatory Syndrome in an Immunosuppressed Patient With SARS-CoV-2
Rafael Garcia-Carretero[SUP] 1 [/SUP], Oscar Vazquez-Gomez[SUP] 1 [/SUP], Maria Ordoñez-Garcia[SUP] 2 [/SUP]
Affiliations
Abstract
Both immune reconstitution inflammatory syndrome (IRIS) and severe coronavirus disease 2019 (COVID-19) are marked by hyperinflammation as a consequence of dysfunction in myeloid cells and increased production of proinflammatory cytokines. Although these features are common to both diseases, their physiopathology remains unclear. Here we report the case of a 63-year-old woman admitted for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In her clinical course, she developed acute respiratory distress syndrome, probably triggered by the use of granulocyte colony-stimulating factor (G-CSF). We hypothesize that G-CSF unmasked IRIS.
Keywords: breast cancer; covid-19; granulocyte colony-stimulating factor; immune reconstitution inflammatory syndrome; immunosuppression.
. 2021 Nov 11;13(11):e19481.
doi: 10.7759/cureus.19481. eCollection 2021 Nov.
Delayed Immune Reconstitution Inflammatory Syndrome in an Immunosuppressed Patient With SARS-CoV-2
Rafael Garcia-Carretero[SUP] 1 [/SUP], Oscar Vazquez-Gomez[SUP] 1 [/SUP], Maria Ordoñez-Garcia[SUP] 2 [/SUP]
Affiliations
- PMID: 34912622
- PMCID: PMC8665849
- DOI: 10.7759/cureus.19481
Abstract
Both immune reconstitution inflammatory syndrome (IRIS) and severe coronavirus disease 2019 (COVID-19) are marked by hyperinflammation as a consequence of dysfunction in myeloid cells and increased production of proinflammatory cytokines. Although these features are common to both diseases, their physiopathology remains unclear. Here we report the case of a 63-year-old woman admitted for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In her clinical course, she developed acute respiratory distress syndrome, probably triggered by the use of granulocyte colony-stimulating factor (G-CSF). We hypothesize that G-CSF unmasked IRIS.
Keywords: breast cancer; covid-19; granulocyte colony-stimulating factor; immune reconstitution inflammatory syndrome; immunosuppression.