tetano
Editor, Senior Moderator
Cureus
. 2022 Jun 24;14(6):e26298.
doi: 10.7759/cureus.26298. eCollection 2022 Jun.
Clinical Profile of SARS-CoV-2-Infected Neonates
Rajesh K Kulkarni[SUP] 1 [/SUP], Chhaya Valvi[SUP] 2 [/SUP], Rahul Dawre[SUP] 2 [/SUP], Uday Rajput[SUP] 2 [/SUP], Rema Nagpal[SUP] 3 [/SUP], Isha Deshmukh[SUP] 2 [/SUP], Pragathi Kamath[SUP] 2 [/SUP], Richa Harwani[SUP] 2 [/SUP], Ramya Srinivasarangan[SUP] 2 [/SUP], Somendra Sonteke[SUP] 2 [/SUP], Apoorva R[SUP] 2 [/SUP], Savita Kamble[SUP] 4 [/SUP], Shilpa Naik[SUP] 4 [/SUP], Ramesh Bhosale[SUP] 4 [/SUP], Rakeesh Waghmare[SUP] 5 [/SUP], Deepak Modi[SUP] 6 [/SUP], Rahul Gajbhiye[SUP] 7 [/SUP], Aarti A Kinikar[SUP] 2 [/SUP]
Affiliations
Abstract
Background There are conflicting data on the mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and few studies have described the clinical course of neonates infected with SARS-CoV-2. Objectives This study investigates the mother-to-child transmission rate and clinical profile of SARS-CoV-2-infected newborns. Methods Data on 304 newborns of 301 mothers with coronavirus disease 2019 (COVID-19) were prospectively collected and analyzed. Reverse transcription-polymerase chain reaction (RT-PCR) determined the presence of SARS-CoV-2 in the placenta, umbilical cord stump, and nasopharyngeal swabs collected within 24h of birth. Clinical and laboratory data of SARS-CoV-2-infected newborns was entered in a structured proforma. Results A total of 20 neonates (6.5%) were positive for SARS-CoV-2, of which 12 were positive only in the nasopharyngeal swab, four cases had the umbilical stump positive, three were positive in the placenta, and one case was positive in all the three specimens collected. Six of the 20 SARS-CoV-2-positive neonates developed severe symptoms. The SARS-CoV-2-positive symptomatic neonates required a more extended stay in hospital compared to their non-symptomatic infected counterparts. Conclusions A proportion of the babies born to SARS-CoV2-infected mothers tested positive and some of these newborns had severe symptoms.
Keywords: clinical profile; inflammation; mother to child transmission; newborn; sars-cov-2.
. 2022 Jun 24;14(6):e26298.
doi: 10.7759/cureus.26298. eCollection 2022 Jun.
Clinical Profile of SARS-CoV-2-Infected Neonates
Rajesh K Kulkarni[SUP] 1 [/SUP], Chhaya Valvi[SUP] 2 [/SUP], Rahul Dawre[SUP] 2 [/SUP], Uday Rajput[SUP] 2 [/SUP], Rema Nagpal[SUP] 3 [/SUP], Isha Deshmukh[SUP] 2 [/SUP], Pragathi Kamath[SUP] 2 [/SUP], Richa Harwani[SUP] 2 [/SUP], Ramya Srinivasarangan[SUP] 2 [/SUP], Somendra Sonteke[SUP] 2 [/SUP], Apoorva R[SUP] 2 [/SUP], Savita Kamble[SUP] 4 [/SUP], Shilpa Naik[SUP] 4 [/SUP], Ramesh Bhosale[SUP] 4 [/SUP], Rakeesh Waghmare[SUP] 5 [/SUP], Deepak Modi[SUP] 6 [/SUP], Rahul Gajbhiye[SUP] 7 [/SUP], Aarti A Kinikar[SUP] 2 [/SUP]
Affiliations
- PMID: 35898362
- PMCID: PMC9308998
- DOI: 10.7759/cureus.26298
Abstract
Background There are conflicting data on the mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and few studies have described the clinical course of neonates infected with SARS-CoV-2. Objectives This study investigates the mother-to-child transmission rate and clinical profile of SARS-CoV-2-infected newborns. Methods Data on 304 newborns of 301 mothers with coronavirus disease 2019 (COVID-19) were prospectively collected and analyzed. Reverse transcription-polymerase chain reaction (RT-PCR) determined the presence of SARS-CoV-2 in the placenta, umbilical cord stump, and nasopharyngeal swabs collected within 24h of birth. Clinical and laboratory data of SARS-CoV-2-infected newborns was entered in a structured proforma. Results A total of 20 neonates (6.5%) were positive for SARS-CoV-2, of which 12 were positive only in the nasopharyngeal swab, four cases had the umbilical stump positive, three were positive in the placenta, and one case was positive in all the three specimens collected. Six of the 20 SARS-CoV-2-positive neonates developed severe symptoms. The SARS-CoV-2-positive symptomatic neonates required a more extended stay in hospital compared to their non-symptomatic infected counterparts. Conclusions A proportion of the babies born to SARS-CoV2-infected mothers tested positive and some of these newborns had severe symptoms.
Keywords: clinical profile; inflammation; mother to child transmission; newborn; sars-cov-2.