tetano
Editor, Senior Moderator
Cureus
. 2023 Feb 2;15(2):e34550.
doi: 10.7759/cureus.34550. eCollection 2023 Feb.
Cerebral Sinus Thrombosis and Immune Thrombocytopenia Post COVID-19 Vaccination: A Case Report and Narrative Review
Azka Ali[SUP] 1 [/SUP], Arthur Dilibe[SUP] 2 [/SUP], Shilpa Rai[SUP] 3 [/SUP], Ayoola Awosika[SUP] 4 5 [/SUP], Adekunle E Omole[SUP] 6 [/SUP], Maryam Ahmed[SUP] 7 [/SUP], Stella Nwosu[SUP] 8 [/SUP]
Affiliations
Abstract
Vaccine-induced immune thrombocytopenia and thrombosis (VITT) following the adenoviral vector COVID-19 vaccine is a rare adverse event. Although the risk of VITT following the COVID-19 vaccine appears to be low, early diagnosis and management can be lifesaving. We present a case of VITT in a young female who presented with persistent headaches and fevers followed by anisocoria and right-sided hemiplegia. Initial imaging was unremarkable, and labs showed thrombocytopenia and elevated d-dimers. Repeat imaging revealed thrombosis in the left transverse and superior sagittal sinuses, and she was diagnosed with VITT. She received combined treatment with intravenous immunoglobulins and systemic anticoagulation, resulting in an increased platelet count and resolution of her neurological symptoms.
Keywords: 2019 novel coronavirus; post-covid 19 vaccine complications; thrombosis with thrombocytopenia syndrome (tts); vaccine-induced prothrombotic immune thrombocytopenia (vipit); vitt covid-19.
. 2023 Feb 2;15(2):e34550.
doi: 10.7759/cureus.34550. eCollection 2023 Feb.
Cerebral Sinus Thrombosis and Immune Thrombocytopenia Post COVID-19 Vaccination: A Case Report and Narrative Review
Azka Ali[SUP] 1 [/SUP], Arthur Dilibe[SUP] 2 [/SUP], Shilpa Rai[SUP] 3 [/SUP], Ayoola Awosika[SUP] 4 5 [/SUP], Adekunle E Omole[SUP] 6 [/SUP], Maryam Ahmed[SUP] 7 [/SUP], Stella Nwosu[SUP] 8 [/SUP]
Affiliations
- PMID: 36879697
- PMCID: PMC9985429
- DOI: 10.7759/cureus.34550
Abstract
Vaccine-induced immune thrombocytopenia and thrombosis (VITT) following the adenoviral vector COVID-19 vaccine is a rare adverse event. Although the risk of VITT following the COVID-19 vaccine appears to be low, early diagnosis and management can be lifesaving. We present a case of VITT in a young female who presented with persistent headaches and fevers followed by anisocoria and right-sided hemiplegia. Initial imaging was unremarkable, and labs showed thrombocytopenia and elevated d-dimers. Repeat imaging revealed thrombosis in the left transverse and superior sagittal sinuses, and she was diagnosed with VITT. She received combined treatment with intravenous immunoglobulins and systemic anticoagulation, resulting in an increased platelet count and resolution of her neurological symptoms.
Keywords: 2019 novel coronavirus; post-covid 19 vaccine complications; thrombosis with thrombocytopenia syndrome (tts); vaccine-induced prothrombotic immune thrombocytopenia (vipit); vitt covid-19.