tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2017 Jun 24. doi: 10.1111/irv.12459. [Epub ahead of print]
[h=1]Curcumin Alleviates Macrophage Activation and Lung Inflammation Induced by Influenza Virus Infection through Inhibiting the NF-κB Signaling Pathway.[/h] Xu Y[SUP]1[/SUP], Liu L[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza A viruses (IAV) result in severe public health problems with worldwide each year. Over-response of immune system to IAV infection leads to complications, and ultimately causing morbidity and mortality.
[h=4]OBJECTIVE:[/h] Curcumin has been reported to have anti-inflammatory ability. However, its molecular mechanism in immune responses remains unclear.
[h=4]METHODS:[/h] We detected the pro-inflammatory cytokine secretion and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) related protein expression in human macrophages or mice infected by IAV with or without curcumin treatment.
[h=4]RESULTS:[/h] We found that the IAV infection caused a dramatic enhancement of pro-inflammatory cytokine productions of human macrophages and mice immune cells. However, curcumin treatment after IAV infection downregulated these cytokines production in a dose-dependent manner. Moreover, the NF-κB has been activated in human macrophages after IAV infection, while administration of curcumin inhibited NF-κB signaling pathway via promoting the expression of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IκBα), and inhibiting the translocation of p65 from cytoplasm to nucleus.
[h=4]CONCLUSIONS:[/h] In summary, IAV infection could result in the inflammatory responses of immune cells, especially macrophages. Curcumin has the therapeutic potentials to relieve these inflammatory responses through inhibiting the NF-κB signaling pathway. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza A viruses (IAV); acute lung injury; curcumin; inflammation; nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)
PMID: 28646616 DOI: 10.1111/irv.12459
Free full text
[h=1]Curcumin Alleviates Macrophage Activation and Lung Inflammation Induced by Influenza Virus Infection through Inhibiting the NF-κB Signaling Pathway.[/h] Xu Y[SUP]1[/SUP], Liu L[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza A viruses (IAV) result in severe public health problems with worldwide each year. Over-response of immune system to IAV infection leads to complications, and ultimately causing morbidity and mortality.
[h=4]OBJECTIVE:[/h] Curcumin has been reported to have anti-inflammatory ability. However, its molecular mechanism in immune responses remains unclear.
[h=4]METHODS:[/h] We detected the pro-inflammatory cytokine secretion and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) related protein expression in human macrophages or mice infected by IAV with or without curcumin treatment.
[h=4]RESULTS:[/h] We found that the IAV infection caused a dramatic enhancement of pro-inflammatory cytokine productions of human macrophages and mice immune cells. However, curcumin treatment after IAV infection downregulated these cytokines production in a dose-dependent manner. Moreover, the NF-κB has been activated in human macrophages after IAV infection, while administration of curcumin inhibited NF-κB signaling pathway via promoting the expression of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IκBα), and inhibiting the translocation of p65 from cytoplasm to nucleus.
[h=4]CONCLUSIONS:[/h] In summary, IAV infection could result in the inflammatory responses of immune cells, especially macrophages. Curcumin has the therapeutic potentials to relieve these inflammatory responses through inhibiting the NF-κB signaling pathway. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza A viruses (IAV); acute lung injury; curcumin; inflammation; nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)
PMID: 28646616 DOI: 10.1111/irv.12459
Free full text