tetano
Editor, Senior Moderator
Am J Public Health. 2014 Feb 13. [Epub ahead of print]
Cumulative Risk of Guillain-Barr? Syndrome Among Vaccinated and Unvaccinated Populations During the 2009 H1N1 Influenza Pandemic.
Vellozzi C, Iqbal S, Stewart B, Tokars J, Destefano F.
Author information
Abstract
Objectives. We sought to assess risk of Guillain-Barr? syndrome (GBS) among influenza A (H1N1) 2009 monovalent (pH1N1) vaccinated and unvaccinated populations at the end of the 2009 pandemic. Methods. We applied GBS surveillance data from a US population catchment area of 45 million from October 15, 2009, through May 31, 2010. GBS cases meeting Brighton Collaboration criteria were included. We calculated the incidence density ratio (IDR) among pH1N1 vaccinated and unvaccinated populations. We also estimated cumulative GBS risk using life table analysis. Additionally, we used vaccine coverage data and census population estimates to calculate denominators. Results. There were 392 GBS cases; 64 (16%) occurred after pH1N1vaccination. The vaccinated population had lower average risk (IDR = 0.83, 95% confidence interval = 0.63, 1.08) and lower cumulative risk (6.6 vs 9.2 cases per million persons, P = .012) of GBS. Conclusions. Our findings suggest that at the end of the influenza season cumulative GBS risk was less among the pH1N1vaccinated than the unvaccinated population, suggesting the benefit of vaccination as it relates to GBS. The observed potential protective effect on GBS attributed to vaccination warrants further study. (Am J Public Health. Published online ahead of print February 13, 2014: e1-e6. doi:10.2105/AJPH.2013.301651).
PMID:
24524517
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24524517
Cumulative Risk of Guillain-Barr? Syndrome Among Vaccinated and Unvaccinated Populations During the 2009 H1N1 Influenza Pandemic.
Vellozzi C, Iqbal S, Stewart B, Tokars J, Destefano F.
Author information
Abstract
Objectives. We sought to assess risk of Guillain-Barr? syndrome (GBS) among influenza A (H1N1) 2009 monovalent (pH1N1) vaccinated and unvaccinated populations at the end of the 2009 pandemic. Methods. We applied GBS surveillance data from a US population catchment area of 45 million from October 15, 2009, through May 31, 2010. GBS cases meeting Brighton Collaboration criteria were included. We calculated the incidence density ratio (IDR) among pH1N1 vaccinated and unvaccinated populations. We also estimated cumulative GBS risk using life table analysis. Additionally, we used vaccine coverage data and census population estimates to calculate denominators. Results. There were 392 GBS cases; 64 (16%) occurred after pH1N1vaccination. The vaccinated population had lower average risk (IDR = 0.83, 95% confidence interval = 0.63, 1.08) and lower cumulative risk (6.6 vs 9.2 cases per million persons, P = .012) of GBS. Conclusions. Our findings suggest that at the end of the influenza season cumulative GBS risk was less among the pH1N1vaccinated than the unvaccinated population, suggesting the benefit of vaccination as it relates to GBS. The observed potential protective effect on GBS attributed to vaccination warrants further study. (Am J Public Health. Published online ahead of print February 13, 2014: e1-e6. doi:10.2105/AJPH.2013.301651).
PMID:
24524517
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24524517