tetano
Editor, Senior Moderator
J Virol. 2015 Oct 14. pii: JVI.02105-15. [Epub ahead of print]
[h=1]Crystal structure of the conserved amino-terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody.[/h] Cho KJ[SUP]1[/SUP], Schepens B[SUP]1[/SUP], Moonens K[SUP]2[/SUP], Deng L[SUP]1[/SUP], Fiers W[SUP]1[/SUP], Remaut H[SUP]2[/SUP], Saelens X[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We report the crystal structure of the M2 ectodomain (M2e) in complex with a monoclonal antibody that binds the amino-terminus of M2. M2e stretches out into the antibody binding site to form an N-terminal β-turn near the bottom of the paratope. This M2e folding differs significantly from M2e in complex with an antibody that binds another part of M2e. This suggests that M2e can adopt at least two conformations that can elicit protective antibodies.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26468526 [PubMed - as supplied by publisher]
[h=1]Crystal structure of the conserved amino-terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody.[/h] Cho KJ[SUP]1[/SUP], Schepens B[SUP]1[/SUP], Moonens K[SUP]2[/SUP], Deng L[SUP]1[/SUP], Fiers W[SUP]1[/SUP], Remaut H[SUP]2[/SUP], Saelens X[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We report the crystal structure of the M2 ectodomain (M2e) in complex with a monoclonal antibody that binds the amino-terminus of M2. M2e stretches out into the antibody binding site to form an N-terminal β-turn near the bottom of the paratope. This M2e folding differs significantly from M2e in complex with an antibody that binds another part of M2e. This suggests that M2e can adopt at least two conformations that can elicit protective antibodies.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26468526 [PubMed - as supplied by publisher]