tetano
Editor, Senior Moderator
J Infect Dis. 2017 Sep 15;216(suppl_4):S555-S559. doi: 10.1093/infdis/jix001.
[h=1]Cross-Reactive Antibody Responses to Novel H5Nx Influenza Viruses Following Homologous and Heterologous Prime-Boost Vaccination with a Prepandemic Stockpiled A(H5N1) Vaccine in Humans.[/h] Levine MZ[SUP]1[/SUP], Holiday C[SUP]1[/SUP], Liu F[SUP]1[/SUP], Jefferson S[SUP]1[/SUP], Gillis E[SUP]1[/SUP], Bellamy AR[SUP]2[/SUP], Tumpey T[SUP]1[/SUP], Katz JM[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Recently, novel highly pathogenic avian influenza H5Nx viruses (clade 2.3.4.4) caused outbreaks in US poultry. We evaluated the potential of a stockpiled A(H5N1) A/Anhui/1/2005 (clade 2.3.4) vaccine to elicit cross-reactive antibody responses to these emerging viruses. Sera from subjects who received 2 doses of MF59-adjuvanted A/Anhui/1/2005, or 1 dose of MF59-adjuvanted A/Anhui/1/2005 following priming with a clade 1 vaccine were characterized by microneutralization assays and modified hemagglutination inhibition (HI) assays. Only heterologous prime-boost vaccination induced modest cross-reactive HI antibody responses to H5Nx viruses. Heterologous prime-boost may provide a more effective vaccination strategy to broaden the antibody responses to emerging viruses.
Published by Oxford University Press for the Infectious Diseases Society of America 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.
[h=4]KEYWORDS:[/h] antibody responses; highly pathogenic avian influenza viruses; pre-pandemic stockpile
PMID: 28934456 DOI: 10.1093/infdis/jix001
[h=1]Cross-Reactive Antibody Responses to Novel H5Nx Influenza Viruses Following Homologous and Heterologous Prime-Boost Vaccination with a Prepandemic Stockpiled A(H5N1) Vaccine in Humans.[/h] Levine MZ[SUP]1[/SUP], Holiday C[SUP]1[/SUP], Liu F[SUP]1[/SUP], Jefferson S[SUP]1[/SUP], Gillis E[SUP]1[/SUP], Bellamy AR[SUP]2[/SUP], Tumpey T[SUP]1[/SUP], Katz JM[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Recently, novel highly pathogenic avian influenza H5Nx viruses (clade 2.3.4.4) caused outbreaks in US poultry. We evaluated the potential of a stockpiled A(H5N1) A/Anhui/1/2005 (clade 2.3.4) vaccine to elicit cross-reactive antibody responses to these emerging viruses. Sera from subjects who received 2 doses of MF59-adjuvanted A/Anhui/1/2005, or 1 dose of MF59-adjuvanted A/Anhui/1/2005 following priming with a clade 1 vaccine were characterized by microneutralization assays and modified hemagglutination inhibition (HI) assays. Only heterologous prime-boost vaccination induced modest cross-reactive HI antibody responses to H5Nx viruses. Heterologous prime-boost may provide a more effective vaccination strategy to broaden the antibody responses to emerging viruses.
Published by Oxford University Press for the Infectious Diseases Society of America 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.
[h=4]KEYWORDS:[/h] antibody responses; highly pathogenic avian influenza viruses; pre-pandemic stockpile
PMID: 28934456 DOI: 10.1093/infdis/jix001