Giuseppe
Emeritus
[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
Crit Care. 2012 Sep 21;16(5):157. [Epub ahead of print]
Statins in pneumonia - magic versus science?
Kruger PS, Thomas RM.
Source: Princess Alexandra Hospital, Ipswich Road, Wooloongabba, Brisbane, 4102 Australia. peter_kruger@health.qld.gov.au.
Abstract
Several studies have investigated the use of statins as an adjunct in the treatment of pneumonia, some with conflicting conclusions. The most recent of these large observational studies again suggests statin use is associated with an improved outcome for patients with pneumonia. How best to incorporate these findings into current practice is of great interest. Hidden confounders plague database interrogation and so cast doubt on the real or causal nature of observed associations. Data from large, observational studies must be complemented by smaller biological studies and randomised controlled trials in an effort to complete missing pieces in the biological puzzle of the use of statins in patients with pneumonia.
PMID: 23025797 [PubMed - as supplied by publisher]
PMCID: PMC3682249 [Available on 2013/9/21]
-
--------
Crit Care. 2012 Sep 21;16(5):157. [Epub ahead of print]
Statins in pneumonia - magic versus science?
Kruger PS, Thomas RM.
Source: Princess Alexandra Hospital, Ipswich Road, Wooloongabba, Brisbane, 4102 Australia. peter_kruger@health.qld.gov.au.
Abstract
Several studies have investigated the use of statins as an adjunct in the treatment of pneumonia, some with conflicting conclusions. The most recent of these large observational studies again suggests statin use is associated with an improved outcome for patients with pneumonia. How best to incorporate these findings into current practice is of great interest. Hidden confounders plague database interrogation and so cast doubt on the real or causal nature of observed associations. Data from large, observational studies must be complemented by smaller biological studies and randomised controlled trials in an effort to complete missing pieces in the biological puzzle of the use of statins in patients with pneumonia.
PMID: 23025797 [PubMed - as supplied by publisher]
PMCID: PMC3682249 [Available on 2013/9/21]
-
--------