tetano
Editor, Senior Moderator
Crit Care Sci
. 2024 Dec 20:36:e202400251en.
doi: 10.62675/2965-2774.20240251-en. eCollection 2024. Long-term mortality of Dutch COVID-19 patients admitted to the intensive care medicine: a retrospective analysis from a national quality registry
[Article in English, Portuguese]
Safira A Wortel[SUP] 1 2 [/SUP], Ferishta Bakhshi-Raiez[SUP] 1 2 [/SUP], Ameen Abu-Hanna[SUP] 1 [/SUP], Dave A Dongelmans[SUP] 2 3 [/SUP], Nicolette F de Keizer[SUP] 1 2 [/SUP]; Dutch COVID-19 Research Consortium[SUP] 4 [/SUP]; Aletta Houwink[SUP] 4 [/SUP], Allard Dijkhuizen[SUP] 5 [/SUP], Annelies Draisma[SUP] 6 [/SUP], Annemiek Rijkeboer[SUP] 7 [/SUP], Arjan Cloïn[SUP] 8 [/SUP], Arthur de Meijer[SUP] 9 [/SUP], Auke Reidinga[SUP] 10 [/SUP], Barbara Festen-Spanjer[SUP] 11 [/SUP], Bas van Bussel[SUP] 12 [/SUP], Bob Eikemans[SUP] 13 [/SUP], Cretièn Jacobs[SUP] 14 [/SUP], David Moolenaar[SUP] 10 [/SUP], Dharmanand Ramnarain[SUP] 15 [/SUP], Dick Koning[SUP] 16 [/SUP], Dirk Boer[SUP] 17 [/SUP], Dirk Verbiest[SUP] 18 [/SUP], Eline van Slobbe-Bijlsma[SUP] 19 [/SUP], Ellen van Koppen[SUP] 20 [/SUP], Els Rengers[SUP] 21 [/SUP], Erik van Driel[SUP] 22 [/SUP], Eva Verweij[SUP] 23 [/SUP], Freya van Iersel[SUP] 24 [/SUP], Gert Brunnekreef[SUP] 25 [/SUP], Hans Kieft[SUP] 26 [/SUP], Herman Kreeftenberg[SUP] 27 [/SUP], Ilanit Hené[SUP] 28 [/SUP], Inge Janssen[SUP] 29 [/SUP], Ionana Drogt[SUP] 30 [/SUP], Iwan van der Horst[SUP] 12 [/SUP], Jan Jaap Spijkstra[SUP] 31 [/SUP], Jan Rozendaal[SUP] 32 [/SUP], Jannet Mehagnoul-Schipper[SUP] 33 [/SUP], Jelle Epker Erasmus[SUP] 34 [/SUP], Jessica Holtkamp[SUP] 35 [/SUP], Johan Lutisan[SUP] 36 [/SUP], Jos van Oers[SUP] 37 [/SUP], Judith Lens[SUP] 38 [/SUP], Laura van Gulik[SUP] 39 [/SUP], Lettie van den Berg[SUP] 40 [/SUP], Louise Urlings-Strop[SUP] 41 [/SUP], Lyuba Georgieva[SUP] 42 [/SUP], Maarten van Lieshout[SUP] 43 [/SUP], Marga Hoogendoorn[SUP] 26 [/SUP], Marissa Vrolijk-de Mos[SUP] 44 [/SUP], Mart de Graaff[SUP] 45 [/SUP], Martha de Bruin[SUP] 46 [/SUP], Martijn Hoeksema[SUP] 47 [/SUP], Martijn van Tellingen[SUP] 48 [/SUP], Michel Barnas[SUP] 49 [/SUP], Michiel Erkamp[SUP] 50 [/SUP], Niels Gritters[SUP] 51 [/SUP], Nuray Kusadasi[SUP] 52 [/SUP], Paul Elbers[SUP] 31 [/SUP], Peter Koetsier[SUP] 53 [/SUP], Peter Spronk[SUP] 54 [/SUP], Peter van der Voort[SUP] 55 [/SUP], Ralph Pruijsten[SUP] 56 [/SUP], Remko de Jong[SUP] 57 [/SUP], Robert-Jan Bosman[SUP] 58 [/SUP], Ronald Wesselink[SUP] 45 [/SUP], Ronny Schnabel[SUP] 12 [/SUP], Roy van den Berg[SUP] 15 [/SUP], Ruud de Waal[SUP] 59 [/SUP], Sesmu Arbous[SUP] 60 [/SUP], Silvia Knape[SUP] 61 [/SUP], Stefaan Hendriks[SUP] 62 [/SUP], Tim Frenzel[SUP] 63 [/SUP], Tom Dormans[SUP] 64 [/SUP], Tom Rijpstra[SUP] 59 [/SUP], Vera Silderhuis[SUP] 65 [/SUP], Wouter de Ruijter[SUP] 66 [/SUP]
Affiliations
in English, Portuguese
Objective: To describe the 12-month mortality of Dutch COVID-19 intensive care unit patients, the total COVID-19 population and various subgroups on the basis of the number of comorbidities, age, sex, mechanical ventilation, and vasoactive medication use.
Methods: We included all patients admitted with COVID-19 between March 1, 2020, and March 29, 2022, from the Dutch National Intensive Care (NICE) database. The crude 12-month mortality rate is presented via Kaplan-Meier survival curves for each patient subgroup. We used Cox regression models to analyze the effects of patient characteristics on 12-month mortality after hospital discharge.
Results: We included 16,605 COVID-19 patients. The in-hospital mortality rate was 28.1%, and the 12-month mortality rate after intensive care unit admission was 29.8%. Among hospital survivors, 12-month mortality after hospital discharge was 2.5% (300/11,931). The hazard of death at 12 months after hospital discharge was greater in patients between 60 and 79 years (HR 4.74; 95%CI 2.23 - 10.06) and ≥ 80 years (HR 22.77; 95%CI 9.91 - 52.28) than in patients < 40 years of age; in male patients than in female patients (HR 1.38; 95%CI 1.07 - 1.78); and in patients with one (adjusted HR 1.95; 95%CI 1.5 - 2.53), two (adjusted HR 4.49; 95%CI 3.27 - 6.16) or more than two comorbidities (adjusted HR 4.99; 95%CI 2.62 - 9.5) than in patients with no comorbidities. Neither vasoactive medication use nor mechanical ventilation resulted in statistically significant results.
Conclusion: For Dutch COVID-19 intensive care unit patients, most deaths occurred during their hospital stay. For hospital survivors, the crude 12-month mortality rate was low. Patient age (older than 60), sex and the number of comorbidities were associated with a greater hazard of death at 12 months after hospital discharge, whereas mechanical ventilation and vasoactive medication were not.
. 2024 Dec 20:36:e202400251en.
doi: 10.62675/2965-2774.20240251-en. eCollection 2024. Long-term mortality of Dutch COVID-19 patients admitted to the intensive care medicine: a retrospective analysis from a national quality registry
[Article in English, Portuguese]
Safira A Wortel[SUP] 1 2 [/SUP], Ferishta Bakhshi-Raiez[SUP] 1 2 [/SUP], Ameen Abu-Hanna[SUP] 1 [/SUP], Dave A Dongelmans[SUP] 2 3 [/SUP], Nicolette F de Keizer[SUP] 1 2 [/SUP]; Dutch COVID-19 Research Consortium[SUP] 4 [/SUP]; Aletta Houwink[SUP] 4 [/SUP], Allard Dijkhuizen[SUP] 5 [/SUP], Annelies Draisma[SUP] 6 [/SUP], Annemiek Rijkeboer[SUP] 7 [/SUP], Arjan Cloïn[SUP] 8 [/SUP], Arthur de Meijer[SUP] 9 [/SUP], Auke Reidinga[SUP] 10 [/SUP], Barbara Festen-Spanjer[SUP] 11 [/SUP], Bas van Bussel[SUP] 12 [/SUP], Bob Eikemans[SUP] 13 [/SUP], Cretièn Jacobs[SUP] 14 [/SUP], David Moolenaar[SUP] 10 [/SUP], Dharmanand Ramnarain[SUP] 15 [/SUP], Dick Koning[SUP] 16 [/SUP], Dirk Boer[SUP] 17 [/SUP], Dirk Verbiest[SUP] 18 [/SUP], Eline van Slobbe-Bijlsma[SUP] 19 [/SUP], Ellen van Koppen[SUP] 20 [/SUP], Els Rengers[SUP] 21 [/SUP], Erik van Driel[SUP] 22 [/SUP], Eva Verweij[SUP] 23 [/SUP], Freya van Iersel[SUP] 24 [/SUP], Gert Brunnekreef[SUP] 25 [/SUP], Hans Kieft[SUP] 26 [/SUP], Herman Kreeftenberg[SUP] 27 [/SUP], Ilanit Hené[SUP] 28 [/SUP], Inge Janssen[SUP] 29 [/SUP], Ionana Drogt[SUP] 30 [/SUP], Iwan van der Horst[SUP] 12 [/SUP], Jan Jaap Spijkstra[SUP] 31 [/SUP], Jan Rozendaal[SUP] 32 [/SUP], Jannet Mehagnoul-Schipper[SUP] 33 [/SUP], Jelle Epker Erasmus[SUP] 34 [/SUP], Jessica Holtkamp[SUP] 35 [/SUP], Johan Lutisan[SUP] 36 [/SUP], Jos van Oers[SUP] 37 [/SUP], Judith Lens[SUP] 38 [/SUP], Laura van Gulik[SUP] 39 [/SUP], Lettie van den Berg[SUP] 40 [/SUP], Louise Urlings-Strop[SUP] 41 [/SUP], Lyuba Georgieva[SUP] 42 [/SUP], Maarten van Lieshout[SUP] 43 [/SUP], Marga Hoogendoorn[SUP] 26 [/SUP], Marissa Vrolijk-de Mos[SUP] 44 [/SUP], Mart de Graaff[SUP] 45 [/SUP], Martha de Bruin[SUP] 46 [/SUP], Martijn Hoeksema[SUP] 47 [/SUP], Martijn van Tellingen[SUP] 48 [/SUP], Michel Barnas[SUP] 49 [/SUP], Michiel Erkamp[SUP] 50 [/SUP], Niels Gritters[SUP] 51 [/SUP], Nuray Kusadasi[SUP] 52 [/SUP], Paul Elbers[SUP] 31 [/SUP], Peter Koetsier[SUP] 53 [/SUP], Peter Spronk[SUP] 54 [/SUP], Peter van der Voort[SUP] 55 [/SUP], Ralph Pruijsten[SUP] 56 [/SUP], Remko de Jong[SUP] 57 [/SUP], Robert-Jan Bosman[SUP] 58 [/SUP], Ronald Wesselink[SUP] 45 [/SUP], Ronny Schnabel[SUP] 12 [/SUP], Roy van den Berg[SUP] 15 [/SUP], Ruud de Waal[SUP] 59 [/SUP], Sesmu Arbous[SUP] 60 [/SUP], Silvia Knape[SUP] 61 [/SUP], Stefaan Hendriks[SUP] 62 [/SUP], Tim Frenzel[SUP] 63 [/SUP], Tom Dormans[SUP] 64 [/SUP], Tom Rijpstra[SUP] 59 [/SUP], Vera Silderhuis[SUP] 65 [/SUP], Wouter de Ruijter[SUP] 66 [/SUP]
Affiliations
- PMID: 39775432
- PMCID: PMC11463994
- DOI: 10.62675/2965-2774.20240251-en
in English, Portuguese
Objective: To describe the 12-month mortality of Dutch COVID-19 intensive care unit patients, the total COVID-19 population and various subgroups on the basis of the number of comorbidities, age, sex, mechanical ventilation, and vasoactive medication use.
Methods: We included all patients admitted with COVID-19 between March 1, 2020, and March 29, 2022, from the Dutch National Intensive Care (NICE) database. The crude 12-month mortality rate is presented via Kaplan-Meier survival curves for each patient subgroup. We used Cox regression models to analyze the effects of patient characteristics on 12-month mortality after hospital discharge.
Results: We included 16,605 COVID-19 patients. The in-hospital mortality rate was 28.1%, and the 12-month mortality rate after intensive care unit admission was 29.8%. Among hospital survivors, 12-month mortality after hospital discharge was 2.5% (300/11,931). The hazard of death at 12 months after hospital discharge was greater in patients between 60 and 79 years (HR 4.74; 95%CI 2.23 - 10.06) and ≥ 80 years (HR 22.77; 95%CI 9.91 - 52.28) than in patients < 40 years of age; in male patients than in female patients (HR 1.38; 95%CI 1.07 - 1.78); and in patients with one (adjusted HR 1.95; 95%CI 1.5 - 2.53), two (adjusted HR 4.49; 95%CI 3.27 - 6.16) or more than two comorbidities (adjusted HR 4.99; 95%CI 2.62 - 9.5) than in patients with no comorbidities. Neither vasoactive medication use nor mechanical ventilation resulted in statistically significant results.
Conclusion: For Dutch COVID-19 intensive care unit patients, most deaths occurred during their hospital stay. For hospital survivors, the crude 12-month mortality rate was low. Patient age (older than 60), sex and the number of comorbidities were associated with a greater hazard of death at 12 months after hospital discharge, whereas mechanical ventilation and vasoactive medication were not.