tetano
Editor, Senior Moderator
Crit Care Explor
. 2020 Nov 25;2(12):e0305.
doi: 10.1097/CCE.0000000000000305. eCollection 2020 Dec.
Predictors of Mortality and Effect of Drug Therapies in Mechanically Ventilated Patients With Coronavirus Disease 2019: A Multicenter Cohort Study
Bernard Lambermont[SUP] 1 [/SUP], Marie Ernst[SUP] 2 [/SUP], Pierre Demaret[SUP] 3 [/SUP], Sandrine Boccar[SUP] 4 [/SUP], Christine Gurdebeke[SUP] 5 [/SUP], Van Brussel Cedric[SUP] 6 [/SUP], Manuel Quinonez[SUP] 7 [/SUP], Christophe J J Dubois[SUP] 8 [/SUP], Thierry Lemineur[SUP] 9 [/SUP], Thierry Njambou[SUP] 10 [/SUP], Benoit Akando[SUP] 11 [/SUP], Damien Wertz[SUP] 12 [/SUP], Julien Higny[SUP] 13 [/SUP], Pierre Delanaye[SUP] 14 [/SUP], Benoit Misset[SUP] 1 [/SUP]
Affiliations
Abstract
We conducted a multicenter cohort study to determine the effect of drug therapies on survival in mechanically ventilated patients with coronavirus disease 2019. All consecutive adult patients admitted to ICU for coronavirus disease 2019 from March 1, 2020, to April 25, 2020, and under invasive mechanical ventilation for more than 24 hours were included. Out of 2,003 patients hospitalized for coronavirus disease 2019, 361 were admitted to ICU, 257 were ventilated for more than 24 hours, and 247 were included in the study. Simple and multiple time-dependent Cox regression models were used to assess the effects of factors on survival. Methylprednisolone administration during the first week of mechanical ventilation was associated with a decrease in mortality rate from 48% to 34% (p = 0.01). Mortality was significantly associated with older age, higher creatinine, lower lymphocyte count, and mean arterial pressure lower than 70 mm Hg on the day of admission.
Keywords: coronavirus; corticosteroids; critical care; mortality; outcome; ventilation.
. 2020 Nov 25;2(12):e0305.
doi: 10.1097/CCE.0000000000000305. eCollection 2020 Dec.
Predictors of Mortality and Effect of Drug Therapies in Mechanically Ventilated Patients With Coronavirus Disease 2019: A Multicenter Cohort Study
Bernard Lambermont[SUP] 1 [/SUP], Marie Ernst[SUP] 2 [/SUP], Pierre Demaret[SUP] 3 [/SUP], Sandrine Boccar[SUP] 4 [/SUP], Christine Gurdebeke[SUP] 5 [/SUP], Van Brussel Cedric[SUP] 6 [/SUP], Manuel Quinonez[SUP] 7 [/SUP], Christophe J J Dubois[SUP] 8 [/SUP], Thierry Lemineur[SUP] 9 [/SUP], Thierry Njambou[SUP] 10 [/SUP], Benoit Akando[SUP] 11 [/SUP], Damien Wertz[SUP] 12 [/SUP], Julien Higny[SUP] 13 [/SUP], Pierre Delanaye[SUP] 14 [/SUP], Benoit Misset[SUP] 1 [/SUP]
Affiliations
- PMID: 33251522
- PMCID: PMC7690766
- DOI: 10.1097/CCE.0000000000000305
Abstract
We conducted a multicenter cohort study to determine the effect of drug therapies on survival in mechanically ventilated patients with coronavirus disease 2019. All consecutive adult patients admitted to ICU for coronavirus disease 2019 from March 1, 2020, to April 25, 2020, and under invasive mechanical ventilation for more than 24 hours were included. Out of 2,003 patients hospitalized for coronavirus disease 2019, 361 were admitted to ICU, 257 were ventilated for more than 24 hours, and 247 were included in the study. Simple and multiple time-dependent Cox regression models were used to assess the effects of factors on survival. Methylprednisolone administration during the first week of mechanical ventilation was associated with a decrease in mortality rate from 48% to 34% (p = 0.01). Mortality was significantly associated with older age, higher creatinine, lower lymphocyte count, and mean arterial pressure lower than 70 mm Hg on the day of admission.
Keywords: coronavirus; corticosteroids; critical care; mortality; outcome; ventilation.