tetano
Editor, Senior Moderator
Crit Care Explor
. 2020 Jun 15;2(6):e0143.
doi: 10.1097/CCE.0000000000000143. eCollection 2020 Jun.
Corticosteroid Administration Is Associated With Improved Outcome in Patients With Severe Acute Respiratory Syndrome Coronavirus 2-Related Acute Respiratory Distress Syndrome
Amit Chopra[SUP] 1 [/SUP], Hau C Chieng[SUP] 1 [/SUP], Adam Austin[SUP] 1 [/SUP], Anupama Tiwari[SUP] 1 [/SUP], Swati Mehta[SUP] 2 [/SUP], Amit Nautiyal[SUP] 1 [/SUP], Ali Hani Al-Tarbsheh[SUP] 2 [/SUP], Esha Jain[SUP] 2 [/SUP], Paul J Feustel[SUP] 3 [/SUP], Boris Shkolnik[SUP] 1 [/SUP], Ariel Jaitovich[SUP] 1 [/SUP]
Affiliations
Abstract
Objectives: To compare the clinical outcome of mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome, who received corticosteroid with those who did not.
Design: Retrospective analysis.
Setting: Intensive care setting.
Patients: All adult mechanically ventilated patients, who were admitted to the ICU between March 20, 2020, and May 10, 2020, for severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome.
Interventions: None.
Measurements and main results: Cohort was divided into two groups based on corticosteroid administration. The primary outcome variable was ventilator-free days at day 28. Secondary outcome variable was ICU-free days at day 30, and hospital-free days at day 30. Consecutive 61 mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome were analyzed. Patient in corticosteroid group as compared with noncorticosteroid group have higher 28-day ventilator-free days (mean, 10.2; median, 7 [interquartile range, 0-22.3] vs mean, 4.7; median, 0 [interquartile range, 0-11]; p = 0.01).There was no significant difference noted in secondary outcomes (ICU-free days at day 30 and hospital-free days at day 30).
Conclusions: Among mechanically ventilated severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome patients, corticosteroids use was associated with significant improvement in 28-day ventilator-free days at day 28, but no significant improvement in ICU-free days at day 30, and hospital-free days at day 30.
Keywords: acute respiratory distress syndrome; corticosteroids; mechanical ventilator; outcome; severe acute respiratory syndrome coronavirus 2.
. 2020 Jun 15;2(6):e0143.
doi: 10.1097/CCE.0000000000000143. eCollection 2020 Jun.
Corticosteroid Administration Is Associated With Improved Outcome in Patients With Severe Acute Respiratory Syndrome Coronavirus 2-Related Acute Respiratory Distress Syndrome
Amit Chopra[SUP] 1 [/SUP], Hau C Chieng[SUP] 1 [/SUP], Adam Austin[SUP] 1 [/SUP], Anupama Tiwari[SUP] 1 [/SUP], Swati Mehta[SUP] 2 [/SUP], Amit Nautiyal[SUP] 1 [/SUP], Ali Hani Al-Tarbsheh[SUP] 2 [/SUP], Esha Jain[SUP] 2 [/SUP], Paul J Feustel[SUP] 3 [/SUP], Boris Shkolnik[SUP] 1 [/SUP], Ariel Jaitovich[SUP] 1 [/SUP]
Affiliations
- PMID: 32696006
- PMCID: PMC7314336
- DOI: 10.1097/CCE.0000000000000143
Abstract
Objectives: To compare the clinical outcome of mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome, who received corticosteroid with those who did not.
Design: Retrospective analysis.
Setting: Intensive care setting.
Patients: All adult mechanically ventilated patients, who were admitted to the ICU between March 20, 2020, and May 10, 2020, for severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome.
Interventions: None.
Measurements and main results: Cohort was divided into two groups based on corticosteroid administration. The primary outcome variable was ventilator-free days at day 28. Secondary outcome variable was ICU-free days at day 30, and hospital-free days at day 30. Consecutive 61 mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome were analyzed. Patient in corticosteroid group as compared with noncorticosteroid group have higher 28-day ventilator-free days (mean, 10.2; median, 7 [interquartile range, 0-22.3] vs mean, 4.7; median, 0 [interquartile range, 0-11]; p = 0.01).There was no significant difference noted in secondary outcomes (ICU-free days at day 30 and hospital-free days at day 30).
Conclusions: Among mechanically ventilated severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome patients, corticosteroids use was associated with significant improvement in 28-day ventilator-free days at day 28, but no significant improvement in ICU-free days at day 30, and hospital-free days at day 30.
Keywords: acute respiratory distress syndrome; corticosteroids; mechanical ventilator; outcome; severe acute respiratory syndrome coronavirus 2.