tetano
Editor, Senior Moderator
Crit Care Explor
. 2021 Dec 20;3(12):e0602.
doi: 10.1097/CCE.0000000000000602. eCollection 2021 Dec.
Association Between Genetic Predictors for C-Reactive Protein and Venous Thromboembolism With Severe Adverse Coronavirus Disease 2019 Outcomes
Boya Guo[SUP] 1 [/SUP], Jessica Williams-Nguyen[SUP] 2 [/SUP], Lu Wang[SUP] 3 [/SUP], Cameron B Haas[SUP] 1 [/SUP], Christopher Kabrhel[SUP] 4 5 [/SUP], Sara Lindström[SUP] 1 2 [/SUP]
Affiliations
Abstract
To assess if genetic predictors for C-reactive protein and risk of venous thromboembolism are associated with severe outcomes among individuals who tested positive for severe acute respiratory syndrome coronavirus 2.
Design: Retrospective cohort study.
Setting: U.K. Biobank.
Patients or subjects: U.K. Biobank participants with European ancestry who were recorded to have a positive polymerase chain reaction test result for severe acute respiratory syndrome coronavirus 2 between March 16, 2020, and August 14, 2020.
Interventions: Not applicable.
Measurements and main results: We constructed separate genetic risk scores for C-reactive protein and venous thromboembolism consisting of 56 and 37 genetic variants that have been significantly associated with venous thromboembolism and C-reactive protein, respectively. Among 1,126 individuals who were diagnosed with coronavirus disease 2019, 48% had a coronavirus disease 2019-related hospitalization, 16% received critical care support, 10% had critical respiratory support, and 21% died from coronavirus disease 2019. Genetic predisposition to high C-reactive protein concentrations was marginally associated with a lower risk of death from coronavirus disease 2019 (odds ratio, 0.85; 95% CI, 0.73-1.00; p = 0.05). No other associations were significant.
Conclusions: Our results do not support associations between polygenic risk for elevated blood C-reactive protein concentrations or venous thromboembolism and severe coronavirus disease 2019 health outcomes. Thus, considering genetic predisposition associated with C-reactive protein concentrations or venous thromboembolism risk is not meaningful for predicting severe coronavirus disease 2019 health outcomes.
Keywords: C-reactive protein; adverse health outcome; coronavirus disease 2019; genetic risk score; inflammation; venous thromboembolism.
. 2021 Dec 20;3(12):e0602.
doi: 10.1097/CCE.0000000000000602. eCollection 2021 Dec.
Association Between Genetic Predictors for C-Reactive Protein and Venous Thromboembolism With Severe Adverse Coronavirus Disease 2019 Outcomes
Boya Guo[SUP] 1 [/SUP], Jessica Williams-Nguyen[SUP] 2 [/SUP], Lu Wang[SUP] 3 [/SUP], Cameron B Haas[SUP] 1 [/SUP], Christopher Kabrhel[SUP] 4 5 [/SUP], Sara Lindström[SUP] 1 2 [/SUP]
Affiliations
- PMID: 34957408
- PMCID: PMC8691492
- DOI: 10.1097/CCE.0000000000000602
Abstract
To assess if genetic predictors for C-reactive protein and risk of venous thromboembolism are associated with severe outcomes among individuals who tested positive for severe acute respiratory syndrome coronavirus 2.
Design: Retrospective cohort study.
Setting: U.K. Biobank.
Patients or subjects: U.K. Biobank participants with European ancestry who were recorded to have a positive polymerase chain reaction test result for severe acute respiratory syndrome coronavirus 2 between March 16, 2020, and August 14, 2020.
Interventions: Not applicable.
Measurements and main results: We constructed separate genetic risk scores for C-reactive protein and venous thromboembolism consisting of 56 and 37 genetic variants that have been significantly associated with venous thromboembolism and C-reactive protein, respectively. Among 1,126 individuals who were diagnosed with coronavirus disease 2019, 48% had a coronavirus disease 2019-related hospitalization, 16% received critical care support, 10% had critical respiratory support, and 21% died from coronavirus disease 2019. Genetic predisposition to high C-reactive protein concentrations was marginally associated with a lower risk of death from coronavirus disease 2019 (odds ratio, 0.85; 95% CI, 0.73-1.00; p = 0.05). No other associations were significant.
Conclusions: Our results do not support associations between polygenic risk for elevated blood C-reactive protein concentrations or venous thromboembolism and severe coronavirus disease 2019 health outcomes. Thus, considering genetic predisposition associated with C-reactive protein concentrations or venous thromboembolism risk is not meaningful for predicting severe coronavirus disease 2019 health outcomes.
Keywords: C-reactive protein; adverse health outcome; coronavirus disease 2019; genetic risk score; inflammation; venous thromboembolism.