tetano
Editor, Senior Moderator
Crit Care
. 2020 Dec 18;24(1):699.
J Clin Med
. 2020 Dec 16;9(12):E4067.
doi: 10.3390/jcm9124067.
Experience in Multiple Sclerosis Patients with COVID-19 and Disease-Modifying Therapies: A Review of 873 Published Cases
Nora M?hn[SUP] 1 [/SUP], Franz F Konen[SUP] 1 [/SUP], Refik Pul[SUP] 2 [/SUP], Christoph Kleinschnitz[SUP] 2 [/SUP], Harald Pr?ss[SUP] 3 [/SUP], Torsten Witte[SUP] 4 [/SUP], Martin Stangel[SUP] 1 [/SUP], Thomas Skripuletz[SUP] 1 [/SUP]
Affiliations
Abstract
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a challenge for all participants in the healthcare system. At the beginning of the pandemic, many physicians asked themselves what risk their patients, especially those with chronic diseases, were exposed to. We present an overview of all patients with multiple sclerosis (MS) and SARS-CoV-2 infection published in the literature so far. In total, there are publications on 873 SARS-CoV-2 positive MS patients and information on the outcome can be given for 700 patients. With regard to the different disease modifying therapies (DMTs), by far the most cases were described under anti-CD20 treatment (n = 317). The mortality rate of all MS patients was 4% and a further 3% required invasive or non-invasive ventilation. When looking at the severe and fatal cases, it is particularly noticeable that patients without DMTs, with previous cardiovascular diseases, or with a severe degree of disability are at risk. Immunosuppressive therapy itself does not appear to be a substantial risk factor. Rather, it is reasonable to assume that the therapies could be protective, either directly, by mitigating the cytokine storm, or indirectly, by reducing the disease activity of MS.
Keywords: COVID-19; SARS-CoV-2 pandemic; disease-modifying therapies; multiple sclerosis.
doi: 10.1186/s13054-020-03417-0.
Risks of ventilator-associated pneumonia and invasive pulmonary aspergillosis in patients with viral acute respiratory distress syndrome related or not to Coronavirus 19 disease
. 2020 Dec 18;24(1):699.
J Clin Med
. 2020 Dec 16;9(12):E4067.
doi: 10.3390/jcm9124067.
Experience in Multiple Sclerosis Patients with COVID-19 and Disease-Modifying Therapies: A Review of 873 Published Cases
Nora M?hn[SUP] 1 [/SUP], Franz F Konen[SUP] 1 [/SUP], Refik Pul[SUP] 2 [/SUP], Christoph Kleinschnitz[SUP] 2 [/SUP], Harald Pr?ss[SUP] 3 [/SUP], Torsten Witte[SUP] 4 [/SUP], Martin Stangel[SUP] 1 [/SUP], Thomas Skripuletz[SUP] 1 [/SUP]
Affiliations
- PMID: 33339436
- DOI: 10.3390/jcm9124067
Abstract
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a challenge for all participants in the healthcare system. At the beginning of the pandemic, many physicians asked themselves what risk their patients, especially those with chronic diseases, were exposed to. We present an overview of all patients with multiple sclerosis (MS) and SARS-CoV-2 infection published in the literature so far. In total, there are publications on 873 SARS-CoV-2 positive MS patients and information on the outcome can be given for 700 patients. With regard to the different disease modifying therapies (DMTs), by far the most cases were described under anti-CD20 treatment (n = 317). The mortality rate of all MS patients was 4% and a further 3% required invasive or non-invasive ventilation. When looking at the severe and fatal cases, it is particularly noticeable that patients without DMTs, with previous cardiovascular diseases, or with a severe degree of disability are at risk. Immunosuppressive therapy itself does not appear to be a substantial risk factor. Rather, it is reasonable to assume that the therapies could be protective, either directly, by mitigating the cytokine storm, or indirectly, by reducing the disease activity of MS.
Keywords: COVID-19; SARS-CoV-2 pandemic; disease-modifying therapies; multiple sclerosis.
doi: 10.1186/s13054-020-03417-0.
Risks of ventilator-associated pneumonia and invasive pulmonary aspergillosis in patients with viral acute respiratory distress syndrome related or not to Coronavirus 19 disease