Mary Wilson
Well-known member
Science Immunology 22 Jun 2021:
Vol. 6, Issue 60, eabj9256
DOI: 10.1126/sciimmunol.abj9256
Jonathan Sprent[SUP]1[/SUP],[SUP]*[/SUP] and Cecile King[SUP]2[/SUP],
Abstract
The side effects of SARS-CoV-2 vaccines are often troubling but may merely reflect transient production of type I interferons, a normal physiological response to contact with invading microorganisms.
... In the vast majority of cases, however, the major complaint is a combination of fever, headache, myalgia and general malaise, affecting ~60% of recipients after the second dose of the vaccines. These symptoms can be troubling and have been the subject of comment in the press and in top scientific journals. Yet, other than vague reference to an ongoing immune response, the actual cause of the side effects has received almost no attention. So what is the cause of these effects? As discussed here, most of the symptoms can likely be attributed simply to exuberant production of a cytokine that plays a vital role in potentiating early stages of the immune response, namely type I interferon (IFN-I).
https://immunology.sciencemag.org/content/6/60/eabj9256
Vol. 6, Issue 60, eabj9256
DOI: 10.1126/sciimmunol.abj9256
Jonathan Sprent[SUP]1[/SUP],[SUP]*[/SUP] and Cecile King[SUP]2[/SUP],
Abstract
The side effects of SARS-CoV-2 vaccines are often troubling but may merely reflect transient production of type I interferons, a normal physiological response to contact with invading microorganisms.
... In the vast majority of cases, however, the major complaint is a combination of fever, headache, myalgia and general malaise, affecting ~60% of recipients after the second dose of the vaccines. These symptoms can be troubling and have been the subject of comment in the press and in top scientific journals. Yet, other than vague reference to an ongoing immune response, the actual cause of the side effects has received almost no attention. So what is the cause of these effects? As discussed here, most of the symptoms can likely be attributed simply to exuberant production of a cytokine that plays a vital role in potentiating early stages of the immune response, namely type I interferon (IFN-I).
https://immunology.sciencemag.org/content/6/60/eabj9256