Emily
Editor, Senior Moderator
https://www.sciencedirect.com/science/article/pii/S0085253821008541
Nicholas L. Li, P. Toby Coates, Brad H. Rovin,
COVID-19 vaccination followed by activation of glomerular diseases: does association equal causation?,
Kidney International,
Volume 100, Issue 5,
2021,
Pages 959-965,
ISSN 0085-2538,
https://doi.org/10.1016/j.kint.2021.09.002.
(https://www.sciencedirect.com/science/article/pii/S0085253821008541)
Keywords: COVID-19; glomerulonephritis; kidney biopsy
Keywords
COVID-19
glomerulonephritis
kidney biopsy
To date, >4 billion doses of the various severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have been administered worldwide in response to the coronavirus disease 2019 (COVID-19) pandemic. Even as widespread vaccination campaigns have contributed to declining case rates, adverse events are appearing beyond those originally reported in the clinical trials of vaccine efficacy and safety. Of particular relevance to the kidney is the increasing number of reports of de novo or reactivation of glomerular diseases (Table 11, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25). The occurrence of glomerular disease after immunization against influenza, pneumococcus, and hepatitis B has been reported in the past.26, 27, 28 The reported patients developed acute onset nephrotic syndrome following vaccination, and kidney biopsies were consistent with a minimal change disease (MCD) pattern of injury. Although temporal association (median onset of 12 days) with vaccination and disease onset suggested a vaccine-related induction of immune injury, the pathophysiological mechanisms responsible have not been determined.
Nicholas L. Li, P. Toby Coates, Brad H. Rovin,
COVID-19 vaccination followed by activation of glomerular diseases: does association equal causation?,
Kidney International,
Volume 100, Issue 5,
2021,
Pages 959-965,
ISSN 0085-2538,
https://doi.org/10.1016/j.kint.2021.09.002.
(https://www.sciencedirect.com/science/article/pii/S0085253821008541)
Keywords: COVID-19; glomerulonephritis; kidney biopsy
Keywords
COVID-19
glomerulonephritis
kidney biopsy
To date, >4 billion doses of the various severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have been administered worldwide in response to the coronavirus disease 2019 (COVID-19) pandemic. Even as widespread vaccination campaigns have contributed to declining case rates, adverse events are appearing beyond those originally reported in the clinical trials of vaccine efficacy and safety. Of particular relevance to the kidney is the increasing number of reports of de novo or reactivation of glomerular diseases (Table 11, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25). The occurrence of glomerular disease after immunization against influenza, pneumococcus, and hepatitis B has been reported in the past.26, 27, 28 The reported patients developed acute onset nephrotic syndrome following vaccination, and kidney biopsies were consistent with a minimal change disease (MCD) pattern of injury. Although temporal association (median onset of 12 days) with vaccination and disease onset suggested a vaccine-related induction of immune injury, the pathophysiological mechanisms responsible have not been determined.