tetano
Editor, Senior Moderator
Influenza Other Respi Viruses. 2012 Feb 28. doi: 10.1111/j.1750-2659.2012.00347.x. [Epub ahead of print]
Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients.
Friesema IH, Meijer A, van Gageldonk-Lafeber AB, van der Lubben M, van Beek J, Donker GA, Prins JM, de Jong MD, Boskamp S, Isken LD, Koopmans MP, van der Sande MA; Dutch ZonMw Influenza A(H1N1) 2009 consortium.
Source
National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands. NIVEL, Netherlands Institute of Health Services Research, Utrecht, The Netherlands. Academic Medical Centre, Amsterdam, The Netherlands. Erasmus Medical Centre, Rotterdam, The Netherlands. Julius Centre for Health Sciences and Primary Care, University Medical Centre, Utrecht, The Netherlands.
Abstract
Please cite this paper as: Friesema et al. (2012). Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients. Influenza and Other Respiratory Viruses. DOI: 10.1111/j.1750-2659.2012.00347.x. The clinical dynamics of influenza A(H1N1) 2009 infections in 61 laboratory-confirmed Dutch cases were examined. An episode lasted a median of 7?5 days of which 2 days included fever. Respiratory symptoms resolved slowly, while systemic symptoms peaked early in the episode and disappeared quickly. Severity of each symptom was rated highest in the first few days. Furthermore, diarrhoea was negatively associated with viral load, but not with faecal excretion of influenza virus. Cases with comorbidities appeared to have higher viral loads than the cases without, suggesting a less effective immune response. These results complement information obtained through traditional surveillance.
? 2012 Blackwell Publishing Ltd.
PMID:
22372759
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22372759
Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients.
Friesema IH, Meijer A, van Gageldonk-Lafeber AB, van der Lubben M, van Beek J, Donker GA, Prins JM, de Jong MD, Boskamp S, Isken LD, Koopmans MP, van der Sande MA; Dutch ZonMw Influenza A(H1N1) 2009 consortium.
Source
National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands. NIVEL, Netherlands Institute of Health Services Research, Utrecht, The Netherlands. Academic Medical Centre, Amsterdam, The Netherlands. Erasmus Medical Centre, Rotterdam, The Netherlands. Julius Centre for Health Sciences and Primary Care, University Medical Centre, Utrecht, The Netherlands.
Abstract
Please cite this paper as: Friesema et al. (2012). Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients. Influenza and Other Respiratory Viruses. DOI: 10.1111/j.1750-2659.2012.00347.x. The clinical dynamics of influenza A(H1N1) 2009 infections in 61 laboratory-confirmed Dutch cases were examined. An episode lasted a median of 7?5 days of which 2 days included fever. Respiratory symptoms resolved slowly, while systemic symptoms peaked early in the episode and disappeared quickly. Severity of each symptom was rated highest in the first few days. Furthermore, diarrhoea was negatively associated with viral load, but not with faecal excretion of influenza virus. Cases with comorbidities appeared to have higher viral loads than the cases without, suggesting a less effective immune response. These results complement information obtained through traditional surveillance.
? 2012 Blackwell Publishing Ltd.
PMID:
22372759
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22372759