County Seasonal flu alert (Influenza in Japan)

[Commonground]

Re: County Seasonal flu alert (Influenza in Japan)

Influenza care and related industries Kawamoto (3604) significantly increase

Core business and the hygienic and medical care and home health agencies and the public <3604> 30, 2009 March 3 during the third Quarter (3Q) announced.

Sales 22500000000 93 million (6.1% YoY), operating income of ? 300 million (an increase of 578.3%), ordinary profit of 100 billion yen (408.2% of increase), net 100000000 profit 19 million yen (an increase of 303.4 percent).

The result of suppression of the medical expenses of medical, hygienic, but the core continues to expand existing strict priority products of the avian flu-related health care products, oral care, including the increase for the elderly also contribute significantly to the sales increase streak care. An increase in sales revenue continued to strengthen infection control-related product needs. The shape also contribute to increased sales revenue of care and child care products and other toiletries.

In terms of profitability due to increased freight costs related to increased sales, successfully compressed to a level similar to the previous fiscal year in SG & A expense reduction efforts in general, led to a significant increase business current account, caused the same period last year This quarter was the incidence of bad loans has also had significant increase in net profit.

Still full, and will continue to have strong sales in key products, sales rose 4.5 percent, while operating profit from ordinary income in the first half deficit, the significant profit expected to increase.

■ producing profit level in the high dividend yield is attractive

[Diagnosis] closing stock price last month hit 27 yen to 365. Until December share price was 400 yen to maintain this year, to 361 yen after hitting a初値, remain stagnant. In support of positive earnings for the full year, however, as the stock market needs to deal with flu-related products can be very high and promising stocks.

The dividend yield of 3.29 percent, closing at a conversion and a high dividend. 3 end of the dividend for the taking, producing profit before you pick up the current high level. (Information: newspapers INTABYU Japan Media-IR)

 

[Commonground]

Re: County Seasonal flu alert (Influenza in Japan)

Pandemic flu: doctors fear without any preparation for training 80 people - Wakayama / Wakayama

Mainichi Daily News in February 2009, a local


Training is designed for a 31 incidence of avian flu, a health center was five Fukiage Wakayama City. About 80 doctors and health center staff members. The training was done in cooperation with hospital officials in the city's administration.

And overseas, conducted a patient in two separate avian flu was confirmed. To determine whether you need a consultation to citizens and visitors to health centers located in the city if the "Center fever"見立TE the participants in the investigation and the role of other citizens. [] Itirou Akira Fujii

 

[HenryN]

Re: County Seasonal flu alert (Influenza in Japan)

Influenza graph

http://idsc.tokyo-eiken.go.jp/weekly/2009/04e.pdf

 

[HenryN]

Re: County Seasonal flu alert (Influenza in Japan)

January 2009, have been isolated from samples taken in hospitals in Fukuoka City, Yamagata, Sendai AH1 subtype, AH3 subtype, B antigens from the vaccine strain of influenza virus type season The divergence of

今シーズン仙台市、山形市、福岡市の医療機関から寄せられたインフルエンザ様患者の臨床検体からMDCK細胞を用いて分離されたインフルエンザウイルスの抗原性を解析した結果、分離されたAH3亜型、AH1亜型、Ｂ型ウイルスのいずれにおいても抗原性がワクチン株と大きく異なっている傾向が見られるので、報告する。​

Season in Sendai, Yamagata, from clinical samples submitted from patients with flu-like hospitals in Fukuoka City as a result of MDCK antigenic analysis of influenza virus was isolated by using cells isolated AH3 subtype, AH1 subtype, B, so the trend is significantly different from the vaccine strain of virus antigen in one, and reports.

昨（2008）年12月～本（2009）年第４週半ばまでの３都市の医療機関の検体由来のインフルエンザウイルスの分離と抗原性
分離ウイルスに対する抗原性は、すべて国立感染症研究所（感染研）分与のワクチン株に対するフェレット抗血清と 1.0％モルモット血球を用いた赤血球凝集抑制（HI）試験によっておこなった。​

Last year (2008) to December (2009), three-four weeks until the middle of the separation of antigen-derived influenza virus in samples of urban medical institutions against viruses
antigenic separation, all of Infectious Diseases Research office (call infection) and ferret antisera against the vaccine strain distribution of 1.0% guinea pig blood cells using a hemagglutination inhibition (HI) test by OKONATTA.

AH1亜型ウイルス ：われわれのHI試験の系では感染研分与の抗体に対するワクチン株抗原のホモ価は1:640である。​

AH1 virus subtype: HI in our value system has the ability to share vaccine antigen homolog of antibodies against infection are sharing call 1:640.

これに対し、これまでの仙台の医療機関由来の分離ウイルス61株のほとんどが、1:80～160とホモ価より２～３管低く、中には1:40や1:20（各１株）と、大きくずれているものもあった。​

The separation of viruses derived from Sendai medical institutions that most of the 61 stocks, one eighty to 160 and from 2-3 down prices Homo tube during the 1:40 and 1:20 (one share for each ), but also by the large gaps.

また、これまで分離された福岡の医療機関由来のウイルス11株もすべてHI価1:80であり、大きくずれていた。​

The virus derived from the separation of medical institutions in the past 11 Hukuoka all share one eighty and HI titer was significantly misaligned.

なお、これらは昨年のAH1亜型ワクチン株であるA/ソロモン株に対する抗血清に対してはまったく反応しない（1:＜10）。​

The last of these is the vaccine strain AH1 subtype A / Solomon for antiserum to stocks will not react at all (1: <10).

AH3亜型ウイルス ：われわれのHI試験の系では感染研分与の抗体に対するワクチン株抗原のホモ価は 1:1,280である。

これに対し、これまで分離された仙台の６株中４株はHI価1:640で、今シーズンワクチン株であるA/Uruguay/716/2007に対する抗血清とよく反応しているが、２株は1:160、1:320と抗原性に若干のずれが生じている。​

However, the separation of Sendai in past 6 HI titer 1:640 share for four shares in the vaccine strain A/Uruguay/716/2007 season and are responsive to anti-serum, Inc. There has been a 1:160,1:320 is slightly misaligned and antigenicity.

一方、福岡の医療機関由来のウイルスでは、分離株８株のうち１株は1:80と大きなずれが認められたが、７株はほぼ抗原性が一致した。​

Meanwhile, the medical origin of Fukuoka virus, an isolate of the eight stocks are allowed to share a one eighty and a large deviation, share almost the same antigen.

Ｂ型ウイルス ：われわれのHI試験の系では感染研分与の抗体に対するワクチン株抗原のホモ価は、山形系統参照ウイルスであるB/Brisbane/3/2007に対する抗血清では1:2,560であり、Victoria系統ウイルスであるB/Malaysia/2506/2004に対する抗血清では1:5,120である。​

B virus: HI in our value system is a homolog of the antigen test for antibody vaccine strain infection of sharing call is B/Brisbane/3/2007 Yamagata lineage viruses in reference to the antiserum and 1:2560, Victoria of virus strains with antiserum against B/Malaysia/2506/2004 is 1:5120.

これに対し、これまで分離された山形の医療機関由来のウイルスは５株あり、そのすべてが山形系統株であったが、その抗原性はHI価 1:320～ 640（それぞれ１株、４株）と、２～３管のずれがあった。​

The virus derived from the separation of medical institutions in Yamagata Prefecture in the past five shares, the shares of all the Yamagata lineage, the HI antigen titer 1:320 - 640 (each a share, share ), and 2-3 of the tube was misaligned.

なお、これらはＢ型Victoria系統のB/マレーシアに対する抗血清にはまったく反応しなかった（1:＜10）。​

The Victoria-B strains are B / Malaysia for the antiserum did not react at all (1: <10).

一方、福岡の医療機関由来の検体からはこれまでにＢ型ウイルス２株を分離している。​

The samples derived from hospitals in Fukuoka so far B virus are two separate stocks.

２株ともVictoria系統であったが、いずれもHI価が80であり、標準株であるB/マレーシアと大きく変わっていた。​

Victoria shares of both the strains of the HI titer of 80, the strain B / Malaysia and was very different.

なお、これらはＢ型山形系統のB/ブリスベンに対する抗血清にはまったく反応しなかった（1:＜10）。​

The Yamagata strains are B-B / Brisbane for the antiserum did not react at all (1: <10).

考　察
現在まで、全国的にAH3亜型、AH1亜型、Ｂ型ウイルスの分離は、ほぼ２：２：１のようだが1) 、宮城県ではAH1亜型ウイルスの分離がほとんどであり、山形県も当初はAH3亜型とＢ型の分離が報告されていたが、最近ではAH1亜型の分離が主流となってきている。​

Judging by current thinking, the national AH3 subtype, AH1 subtype, B virus isolation, but as an almost 2:2:1), in Miyagi Prefecture in AH1 is little separation of the virus subtype There, the initial AH3 Yamagata and subtype B was the separation of the type reported in recent AH1 is becoming mainstream and the separation of the subtype.

一方、われわれが本年第１週から開始した福岡市の医療機関由来のウイルス分離の成績からは、現在福岡市ではAH3亜型、AH1亜型、Ｂ型の流行の三つ巴状態が示唆されている。​

Meanwhile, this year we have a separation from the results of medical viruses from Fukuoka week starting from, Fukuoka is currently AH3 subtype, AH1 subtype, B has been suggested that the epidemic status of cutthroat contract .

こうした中、今後注意すべきと思われる点が二つあるので以下に述べる。​

Meanwhile, as described below so that there are two points to note.

１．​

1.

Ｂ型の流行 ：今回の解析で、山形と福岡という地理的に離れた地域での分離株が、それぞれ山形系統とVictoria系統に分かれていることが示された。​

Prevalence of type B: In this analysis, the isolates in geographically separated areas of Fukuoka and Yamagata, Yamagata and Victoria lines and it was shown that the system is divided into.

その両方で標準株との抗原性の「ずれ」がかなり大きいことから、今シーズンの今後の流行の広がり方によっては、来シーズンの国内ワクチン株の選択に大きい影響を与えるので、ウイルス株サーベイランスがさらに重要となってくる。​

その両方で標準株との抗原性の「ずれ」がかなり大きいことから、今シーズンの今後の流行の広がり方によっては、来シーズンの国内ワクチン株の選択に大きい影響を与えるので、ウイルス株サーベイランスがbecome more important.

２．​

Two.

AH1亜型ウイルスの抗原性に対する監視の意義 ：現在、日本でもオセルタミビル耐性の遺伝子を持ったウイルスが分離されたA/H1N1ウイルス株のほとんどを占めてきている2) ことが臨床の現場で大きな話題になっており、このため、Ａ型インフルエンザに対するオセルタミビルの使用は、臨床現場では控えられる傾向にある。​

Significance of monitoring for the AH1 antigenic subtype of the virus: The virus was isolated with a gene resistant to oseltamivir A/H1N1 in Japan have been major virus strain 2) a major topic in the field of the clinical has, because of this, A use of oseltamivir for pandemic flu, the site of treatment tends to be withheld.だが、現在のデータによれば、流行中のAH1亜型ウイルスの抗原性はワクチンの抗原性と一致しているため、ワクチン接種の有効性が期待されるとされている2) 。

しかし、今回のわれわれの解析では、仙台でも福岡でも、必ずしもそうではないことが示唆された。​

However, our analysis was in Fukuoka in Sendai, it was not suggested that.

よって、今後、インフルエンザの予防と治療を考える上で、全国レベルでのAH1亜型分離株の抗原性の調査に加えて、インフルエンザワクチンの臨床効果についての調査が必要であるとともに、薬剤耐性についても遺伝子型やNAの活性阻害剤抵抗性だけでなく、同薬剤が臨床的に無効なのかどうかについても早急に調査する必要性があると思われる。​

Therefore, future thinking on prevention and treatment of influenza, at the national level in addition to the survey AH1 antigenic subtype of the isolate, and research is needed about the clinical effectiveness of influenza vaccines, for drug resistance and genotypic resistance to NA inhibitors as well as activity, may have the need to quickly investigate whether the drug is clinically invalid.

参　考１）国立感染症研究所ホームページ、インフルエンザ流行レベルマップ第２週２）IASRインフルエンザ速報記事、 http://idsc.nih.go.jp/iasr/rapid/pr3483.html​

We see a) Home Page National Institute of Infectious Diseases, Map No. 2-level flu week 2) IASR flu news article, http://idsc.nih.go.jp/iasr/rapid/pr3483.html

国立病院機構仙台医療センター臨床研究部ウイルスセンター岡本道子　近江　彰　千葉ふみ子　伊藤洋子　西村秀一同小児科　貴田岡節子　田澤雄作同呼吸器内科　斉藤若菜　三木祐永井小児科　永井幸夫、庄司内科　庄司　眞（以上仙台市）​

Yuu Nagai Nagai Yukio Miki Saitou Wakana pediatric respiratory medicine at the pediatric Kitaoka Setsuko Tazawa Yuusaku Hazime Hide Hiroko Nishimura Akira Tiba Humiko Itoo Okamoto Mitiko Oumi Virus Research Department, Clinical Center, National Hospital Organization Sendai Medical Center, Internal Medicine Shiyouzi Makoto Shoji (Sendai or more)

勝島小児科　勝島史夫（山形市）​

Shima Tsuyoshi Katsushima Humio Pediatrics (Yamagata)

しばおクリニック　芝尾京子、しんどう小児科　進藤静生、高崎小児科　高崎好生、やました小児科　山下祐二（以上福岡市）​

Kyoko tail grass your lawn clinic, pediatric shock Shindou Shizuo, Takasaki Takasaki Yoshio Pediatrics, Pediatrics Yokohama Yamashita Yuuzi (Fukuoka or more)

http://66.102.1.101/translate_c?hl=..._qdr=d&usg=ALkJrhj1W8WRGxiRtsUtEEODDwMXTH6C4Ahttp://translate.google.com/transla...y&hl=en&lr=&rlz=1T4GGLL_enUS305US306&as_qdr=d

 

[HenryN]

Re: County Seasonal flu alert (Influenza in Japan)

<NEWS> January 2009, have been isolated from samples taken in hospitals in Fukuoka City, Yamagata, Sendai AH1 subtype, AH3 subtype, B antigens from the vaccine strain of influenza virus type season The divergence of

​

The last of these is the vaccine strain AH1 subtype A / Solomon for antiserum to stocks will not react at all (1: <10).


http://translate.google.com/transla...y&hl=en&lr=&rlz=1T4GGLL_enUS305US306&as_qdr=d

The H1N1 knows how to evolve faster than vaccine manufacturers.
Chasing Tamiflu resistant H1N1 is hazardous to the world's health.

 

[HenryN]

Re: County Seasonal flu alert (Influenza in Japan)

Yahoo translation:

< January bulletin of >2009, AH1 sub- type and the AH3 sub- type where separation is continued from the inspection body which was picked with the medical institution of Sendai city Yamagata city & Fukuoka city, this season of the B type influenza virus about the alienation of antigenicity from vaccine stocks

In order this season to be moved aside from the medical institution of Sendai city, Yamagata city and Fukuoka city influenza, because the result of analyzing the antigenicity of the influenza virus which is separated making use of the MDCK cell from the clinical inspection body of the patient, AH3 sub- type and the AH1 sub- type which are separated, either of the B type viruses you can see the tendency where antigenicity differs from vaccine stocks largely in, it reports.
Previous (2008) year December - book (2009) year separation and antigenicity of influenza virus of inspection body origin of medical institution of 3 cities to the 4th week middle
It did the antigenicity for the separated virus, all national infection symptom laboratories (the infection research) the ferret antiserum for the vaccine stocks of distribution and the red corpuscle cohesion control which uses 1.0% guinea pig blood corpuscle (HI) with test.
AH1 sub- type virus: With system of our HI tests as for homo- value of the vaccine stocks antigen for the antibody of infection research distribution 1: 640 is. Vis-a-vis this, the majority of separated virus 61 stocks of former Sendai medical institution origin, 1: 80 - 160 and 2 - 3 tubes to be lower than homo- value, in 1: 40 and 1: 20 (each 1 stocks) with, largely there were also some which have slipped. In addition, virus 11 stocks of the Fukuoka medical institution origin which is separated so far all HI values 1: 80 was, had slipped largely. Furthermore, these do not react vis-a-vis the antiserum for a/SOLOMON stocks which are AH1 sub- form chin stocks of last year completely (1: <10).
AH3 sub- type virus: With system of our HI tests homo- value of the vaccine stocks antigen for the antibody of infection research distribution is the 1:1,280. Vis-a-vis this, as for 4 stocks in 6 stocks of Sendai which is separated so far HI value 1: With 640, it has reacted with the antiserum for A/Uruguay/716/2007 which this season is vaccine stocks well, but as for 2 stocks 1: 160 and 1: The somewhat gap has occurred in 320 and antigenicity. On the one hand, with the virus of the Fukuoka medical institution origin, as for the inside 1 stocks of isolate 8 stocks 1: 80 it could recognize the big gap, but as for 7 stocks almost antigenicity agreed.
B type virus: With system of our HI tests as for homo- value of the vaccine stocks antigen for the antibody of infection research distribution, with the antiserum for B/Brisbane/3/2007 which is the Yamagata systematic reference virus 1: With the antiserum for B/Malaysia/2506/2004 which 2,560 is, is the Victoria systematic virus 1: 5,120 is.
Vis-a-vis this, as for the virus of the Yamagata medical institution origin which is separated so far there were 5 stocks, the everything of that was Yamagata systematic stocks, but the antigenicity the HI value 1:320 - 640 (respectively 1 stocks and 4 stocks) with, had the gap of 2 - 3 tubes. Furthermore, these did not react to the antiserum for B/Malaysia of B type Victoria system completely (1: <10).
On the one hand, B type virus 2 stocks are separated from the inspection body of the Fukuoka medical institution origin so far. Also 2 stocks were Victoria system, but it had changed from B/Malaysia where in each case HI value is, 80 is standard stocks largely. Furthermore, these did not react to the antiserum for Venn B/Bliss of B type Yamagata system completely (1: <10).
Consideration　
To presently, nationwide AH3 sub- type and AH1 sub- type, separation of the B type virus almost 2: 2: Like 1 but 1), in Miyagi prefecture separation of the AH1 sub- type virus was the majority, Yamagata prefecture at the beginning separation of AH3 sub- type and B type was reported, but recently separation of AH1 sub- type has become main current. Presently in Fukuoka city three way state of popularity of AH3 sub- type, AH1 sub- type and B type is suggested from record of virus separation of medical institution origin of Fukuoka city which on the one hand, we start from this year 1st week.
Because the point where it is thought that in such, in the future it should note, is two you express below.
Popularity of 1.B type: The isolate at the area which with the latest analysis, you call Yamagata and Fukuoka and is far geographically was shown, having divided into the respective Yamagata system and Victoria system. Being the both, to come antigenicity of standard stocks “to slip”, from rather large thing, depending upon the method of spreading the future popularity of this season, because it produces the effect which is large to the selection of domestic vaccine stocks of season, virus stocks surveillance furthermore becomes important.
Meaning of the supervision for the antigenicity of the 2.AH1 sub- type virus: Presently, 2 where the majority of a/H1N1 virus stocks where the virus which had the gene of [oserutamibiru] tolerance even in Japan is separated has been occupied) thing on clinical site has become big topic, because of this, as for use of [oserutamibiru] for a type influenza, on clinical site there is a tendency which refrains. But, according to the present data, as for antigenicity of the AH1 sub- type virus which is in the midst of becoming popular because it matches the antigenicity of the vaccine, 2 where it is assumed that effectiveness of vaccination is expected,). But, with the latest our analysis, in Sendai and, always so it was suggested in Fukuoka that is not. Depending, in the future, prevention of the influenza and when thinking of remedy, at nationwide level investigation in addition to the investigation of antigenicity of the AH1 sub- type isolate, concerning the clinical effect of the influenza vaccine is necessary and also, concerning medicine tolerance not only genotype and the active inhibitor resistance of NA, whether or not the same medicine clinically is invalid, it is thought that there is a necessity which is investigated urgently concerning.
Reference　
1) National infection symptom laboratory home page, influenza popularity level map 2nd week
2) IASR influenza bulletin article, http://idsc.nih.go.jp/iasr/rapid/pr3483.html National hospital mechanism Sendai medical center clinical division of research virus center
Hidekazu Nishimura Youko [hu] seeing child Itoh Chiba Akira Omi Mitiko Okamoto
The same pediatrics your Taoka paragraph child rice field 澤 Yuusaku
The same breathing apparatus internal medicine Saito Wakana Miki 祐
Yukio pediatrics Nagai Nagai, internal medicine Shoji Shoji 眞 (or more Sendai city)
Victory island pediatrics victory island Humio (Yamagata city)
Lawn clinic lawn tail Kiyouko, pediatrics Shin rattan quiet raw and Takasaki pediatrics Takasaki good raw, ashamedly it is be tired pediatrics Yamashita 祐 two (or more Fukuoka city)

 

[HenryN]

Re: County Seasonal flu alert (Influenza in Japan)

Commentary

http://www.recombinomics.com/News/02020902/H274Y_Japan_Explodes.html

 

[Commonground]

Re: County Seasonal flu alert (Influenza in Japan)

From Post #43 [Thanks, Dr. Niman]

 

[Commonground]

Re: County Seasonal flu alert (Influenza in Japan)



<big><big>Commentary</big></big>
Tamiflu Resistant H1N1 Explodes in Japan
Recombinomics Commentary 18:10
February 2, 2009

"It's been kind of a ho-hum year," Dr. Nancy Cox, influenza chief at the Centers for Disease Control and Prevention, told a meeting of flu specialists Monday.

The above may be true for the beginning of the season in the United States, but reports coming out of Korea and Japan indicate major changes will be noticed I the US in the next few weeks.

Last month H1N1 exploded on South Korea, where almost all influenza this season is Tamiflu resistant H1N1. The high level of activity was reported for the entire month, with more than 400 isolates collected each week.

Similarly, H1N1 exploded last week in Japan. The jump in cases led to school closings across the country, with warnings to stay away from crowds and wear masks. The warnings were based on the number of patients per reporting location to rise above 30 (see updated map), which was widespread and included Tokyo, where 136 elementary and 36 middle schools were closed last week.

Earlier in the season H1N1 accounted for 1/3 of flu cases in Japan, but last week?s activity moved the number above 54.6% indicating much of the increase was due to Tamiflu resistant H1N1. Moreover, a recent report from the Japan NIH indicated the H1N1 was rapidly losing effectiveness, with ferret titers 4-8 fold lower than the Brisbane/59 used as the vaccine target, and in some samples the activity was close to the lower limit of detection.

The phylogenetic analysis of H1N1 closing schools in Japan in the fall was similar to the H1N1 in the United States, so it is likely that the explosion in cases in Korea and Japan will soon be in the United States. There have already been reports of school closings or alerts in Texas, where Tamiflu resistance is widespread and the sequences from Texas were similar to Japan as well as HI, PA, and WI in the US. Moreover, the H1N1 in Italy is also developing vaccine resistance.

Media Links

 

[HenryN]

Re: County Seasonal flu alert (Influenza in Japan)

Commentary

http://www.recombinomics.com/News/02020903/H274Y_Japan_Vaccine.html

 

[AlaskaDenise]

Re: County Seasonal flu alert (Influenza in Japan)

Commentary

http://www.recombinomics.com/News/02020903/H274Y_Japan_Vaccine.html

Commentary

Vaccine Resistant H1N1 in Japan Raises Concerns
Recombinomics Commentary 21:44
February 2, 2009


majority of separated virus 61 stocks of former Sendai medical institution origin, 1: 80 - 160 and 2 - 3 tubes to be lower than homo- value, in 1: 40 and 1: 20 (each 1 stocks) with, largely there were also some which have slipped. In addition, virus 11 stocks of the Fukuoka medical institution origin which is separated so far all HI values 1: 80 was, had slipped largely. Furthermore, these do not react vis-a-vis the antiserum for a/SOLOMON stocks which are AH1 sub- form chin stocks of last year completely (1: <10)

The above translation is from an NIH Japan report on H1N1 testing from patients in two medical centers (Sendai and Fukuoka). Japan has just reported an explosion in flu cases last week (see updated map), which are largely H1N1. Most H1N1 in Japan is Tamiflu resistant, but the latest report looks at reactivity with the seasonal vaccine.

Antisera from ferrets immunized with the trivalent vaccine, which uses Brisbane/59/2007 as the H1N1 target for the current season has a titer of 640 against the target, but that levels drops 4-8 fold when H1N1 from the above medical centers are used. Moreover, in some cases the levels falls 16-32 fold, which explains why some who were vaccinated are still getting infected with H1N1. This was recently reported for patients in Italy, and the above cross-reactivity data suggest the protection failure may be widespread.

Earlier studies on H1N1 from elementary school children in Sendai identified H1N1 that was virtually identical to H1N1 in the United States (HI, TX, PA), raising concerns of similar resistance. An earlier outbreak at a high school in Texas included infection of the school nurse, who had been vaccinated. Similarly, recent outbreaks at a Texas university (SMU) and boarding school (Texas Military Institute) have been reported, suggesting that outbreaks in the United States are likely.

The vaccine resistance is not a surprise. Although the Tamiflu resistant H1N1 is the Brisbane strain (clade 2B), it has evolved away from the 2007 target. H274Y is a genetic hitch-hiker on an H1N1 which ahs acquired a number of HA and NA changes which were on a clade 2C (Hong Kong) genetic background. However, the Hong Kong strain has also not been a vaccine target, so these components have not been in H1N1 vaccines.

Last season the vaccine target was changed from New Caledonia/20/1999 (clade 1) to Solomon Islands/3/2006 (clade 2A). Solomon Islands was called a “match” by agencies in the United States and Europe, but last season Solomon Island had been replaced by Brisbane and Hong Kong, but initially all clade 2 isolates were classified as “Solomon Island-like”. However, phylogenetic analysis easily distinguished each sub-clade and suggested that there would be cross reactivity issues. Initial reference antisera was made against Brisbane grown in eggs and that antisera cross reacted with all three sub-clades, leading to statements that the clade 2B and clade 2C were antigentically indistinguishable from clade 2A. However, antisera directed against Brisbane grown in mammalian cells readily distinguished the three sub-clades.

Consequently, the target was changed from Solomon Island to Brisbane this season, but the Brisbane target was from 2007, and the 2008 Brisbane has already evolved away from the 2007 target. The evolved strain was Tamiflu resistant and had additional changes, which increased this season, which led to even less cross reactivity.

Thus, at this time the H1N1 in Japan has H274Y which creates Tamiflu resistance, but it also has evolved away from the 2007 strain, so it is also vaccine resistant.

Chasing Tamiflu resistant H1N1 with mismatched vaccines is hazardous to the worlds health because of diminished protection and an increased risk if dual infections involving H1N1 and H5N1 leading to Tamiflu resistant H5N1.

.

 

[HenryN]

Re: County Seasonal flu alert (Influenza in Japan)

Flu alert in order!

東京都内のインフルエンザ患者の数が流行警報基準に達しました。​

Epidemic has reached the standard warning that the number of flu patients in Tokyo.

前回より４年ぶりの警報発令となっています。​

And 4 from the previous warning issued on Wednesday.

今後も更に流行拡大も十分に考えられますので，感染予防を心がけてください。​

It may be fashionable enough to expand further in the future, please try to prevent infection.

※インフルエンザ等感染症相談窓口（感染症の一般的予防方法，流行状況や予防接種の意義，有効性，副反応等） （株）保健同人社　月曜日から金曜日（祝祭日除く）午前９時３０分～午後５時　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　電話：０３－３２３４－３４７９​

※ Consultation infection and flu (prevention of common infectious diseases, vaccination status and significance of the prevalence, efficacy, and side reaction) (shares)保健同人社Monday through Friday (excluding holidays) 9:30 -- Tel :03-3234 at 5 pm -3479

http://translate.google.com/transla...1&hl=en&lr=&rlz=1T4GGLL_enUS305US306&as_qdr=d

 

[HenryN]

Re: County Seasonal flu alert (Influenza in Japan)

<TABLE class=single cellSpacing=0 cellPadding=0 width="100%"><TBODY><TR><TH> Date </TH><TD class=data>

2009年02月02日(月) 17:30​

2009 Monday, February 2 17:30
</TD></TR><TR><TH width="30%">

タイトル​

Title </TH><TD class=data width="70%">

ｲﾝﾌﾙｴﾝｻﾞ警報及び学級閉鎖(8)について​

Sign-in state mail-in ?ﾞAn alarm and closed class (8)
</TD></TR><TR><TH>

内容​

Content </TH><TD class=data><!-- WF1.3 -->

福岡県は、２年ぶりに「インフルエンザ流行発生警報」を発表しました。​

Fukuoka, two years after "flu caused alarm".

これは、約２００ヶ所の定点医療機関で、１医療機関あたり週間平均患者数が３０人を超えると発表されます。​

This point of about 200 medical institutions in place, the average weekly number of patients per medical institution will be declared more than 30 people.

１９日から２５日までの患者数は44.1人。​

From 19 to 25 patients is 44.1 days.

＜地域別の状況＞​

<Regional situation>

福岡地区　47.75人　　北九州地区　43.61人筑豊地区　41.27人　　筑後地区　　38.53人​

47.75 Kitakyushu City, Fukuoka City people who Chikuho 41.27 City 43.61 District 38.53 Chikugo people who

また、本日提供のあった、インフルエンザによる学級閉鎖の情報をお知らせいたします。​

The offer was for today, you will receive the information of the flu-class closure.

感染はまだ拡大する恐れがあります。​

Infection may lead to expansion.

感染防止には、くれぐれもご注意ください。​

To prevent infection, please note repeatedly.

●牟田山中学校　１年生全５クラス：学年閉鎖（２／２～２／３）​

● Muta Yamanaka an entire school year 5 class: school closure (2 / 2 to 2 / 3)

＜インフルエンザ予防には＞​

<In the prevention of influenza>

・外出後にはうがいや手洗いをきちんとしましょう。​

No, you got your washing hands after going out the crawl.

・十分に栄養や睡眠をとり、体調管理に努めましょう。​

Take enough sleep and nutrition, health management努MEMASHOU.

・咳やくしゃみは口と鼻を押さえ、回りに広めないようにしましょう。​

Cough or sneeze is holding the mouth and nose, and make sure広MENAI around.

・症状がある人はマスクを正しく着用しましょう。​

People have a right to wear masks your symptoms.

</TD></TR></TBODY></TABLE>

http://translate.google.com/transla...en&lr=&rlz=1T4GGLL_enUS305US306&sa=N&as_qdr=d

 

[HenryN]

Re: County Seasonal flu alert (Influenza in Japan)

Updated map

http://maps.google.com/maps/ms?hl=e...746512,136.450195&spn=15.740414,25.620117&z=5

 

[HenryN]

Re: County Seasonal flu alert (Influenza in Japan)

インフルエンザで閉鎖急増　新たに７校、警報継続

2009年2月3日

<!-- 写真エリア --><TABLE class=Photo-undefine cellSpacing=0 cellPadding=0 width=100 border=0><TFOOT><TR><TD>インフルエンザの流行で、売れ行きが好調なマスク＝福井市大島町のＶドラッグ大島薬局で

</TD></TR></TFOOT><TBODY><TR><TD>

</TD></TR></TBODY></TABLE><!-- /写真エリア/ -->　県内で１月中にインフルエンザ（集団風邪）により、学校、学年、学級閉鎖を実施した施設は１月２９日現在で、延べ３０施設となった。県健康増進課によると、２００６年からの４年間では最多。

　県は、同月１５日にインフルエンザ注意報を発令、２８日にインフルエンザ警報を発令しており、現在も続いている。

　県は２日、新たに７校で学校閉鎖などを実施すると発表した。期間は３日からの１－３日間。累計の閉鎖施設数は延べ３７施設、欠席者は６４５人となった。

　学校を閉鎖するのは坂井市春江西幼稚園と大野市上庄幼稚園。１つの学年を閉鎖するのは勝山市勝山中部中、越前市大虫小。福井市中藤小と越前市武生南小、越前町宮崎小は１学級を閉鎖する。

　インフルエンザの予防対策をＰＲする福井健康福祉センター（福井市）の担当者は「対策で一番効果的なのは手洗い。流水でいいので、手首までしっかり洗って」と呼び掛ける。

　インフルエンザの流行に伴い、県内の薬局ではマスクの売れ行きが好調で在庫も品薄に。福井市大島町のＶドラッグ大島薬局では、鼻に接する部分にワイヤの入ったマスクや、９９・９９％までウイルスの侵入を防ぐマスクの人気が高いという。
　（増田紗苗）
http://tabi.chunichi.co.jp/

 

[HenryN]

Re: County Seasonal flu alert (Influenza in Japan)

A sharp increase in flu-seven schools closed, continuous alarm
February 3, 2009

The flu epidemic, a strong demand mask = V in the town of Fukui Oshima Oshima pharmacy drugs


With influenza in a prefecture (cold group), school, grade, classroom facilities were closed in the current January 29 date, a total of 30 and more. According to the County Department of Health Promotion, 2006, four years from five.

Province, October 15 issued a warning to the flu, 28 have issued a warning to the flu, that continues today.

County on July 2, announced that seven new implementation in schools and school closure. The three-day period from 1-3 days. The cumulative total number of facilities closed 37 facilities, 645 were absentee.

Of the closure of the school and kindergarten kindergarten上庄City West Harue Ohno Sakai City. 1 of the closure of the school year is in the middle of the city Katsuyama Katsuyama, Echizen City大虫small.武生南small city with small中藤Fukui Echizen, Echizen is a small town close Miyazaki classes.

PR flu prevention measures in health and welfare centers to Fukui (Fukui) is representative of "the most effective measures in restrooms. So good with running water, wash well to the wrist" and call.

The flu epidemic in the prefecture of the pharmacies are in short supply and strong demand mask stock. Fukui City, the town of Oshima Oshima V drug at a pharmacy, a mask or treat the nasal portion of the wire, 99.99% of the popular mask to prevent viruses.

(Seedling gauze Masuda)

 

[tropical]

Re: County Seasonal flu alert (Influenza in Japan)

Thank you Dr. Niman, Commonground and AD.


By summing and extracting from all these translated/commented texts (thanks to FT we can have news which were negated from big int. health "watcher" institutions and other "news at the glance" TV),
it seems that:

#51 (Rec.txt):
"...
Thus, at this time the H1N1 in Japan has H274Y which creates Tamiflu resistance, but it also has evolved away from the 2007 strain, so it is also vaccine resistant.

Chasing Tamiflu resistant H1N1 with mismatched vaccines is hazardous to the worlds health because of diminished protection and an increased risk if dual infections involving H1N1 and H5N1 leading to Tamiflu resistant H5N1.
..."

I shall try to resume with an (?) (maybe wrongly) the here cited situation for the ones who wants to make more clear the level of danger at the moment
(because there were so much texts about, and this can be confusing for the non health specialists FT readers).

The recent worldwide episodes (one displayed yesterday during an country media release on TV direct) of rapid gripping unconsiousness, pneumonia, and other mixed simptoms, are coming from this evolved AH1N1 Tamiflu and seasonal vaccine resistant flu strain. (?)

It was already in S.Corea, parts of Russia/China, now it is in Japan, and it is/should (?) spread wide in USA/EU, where is already present in minor quantity than now in Japan.(?)

Additionaly, now became clear that the previous (2007) form of AH1N1 resistant to Tamiflu and quoted with relative inoque gravity, changed, and now became more infectious, wide spread, and with serious outcomes to the infected ones (?)

Feel it free to correct the above if incorrect.

 

[Giuseppe]

Re: County Seasonal flu alert (Influenza in Japan)

A major antigenic drift variation in an human influenza virus cannot be discounted, when there is still a lack of information from authoritative sources (WHO or others). In the past happened, when several intrasubtypic variations created strains of H1N1 with enhanced virulence ('40 of XX century).

But perhaps - and possibly - there are several things all together are resulting in a such widespread influenza activity in some Asian countries.

For examples: some people are hit by economic recession, more stressed, with reduced incomes, perhaps difficulties to seek medical advices if unemployed or in the brink of impoverishment.

Also, a cold winter adds further damage to our immune system.

Some countries have based their fight against seasonal flu on antivirals usage; this was probably a mistake, at least a widespread usage even for otherwise healthy general population.

Some days at home could be best spent than the not yet demonstrated benefit of drugs.

But before the economic recession start, time was measured by money earned or lost.

No time to leave for illness. No time to leave children at home because both parents are at work; old age people too poor to seek medical attention...

Result: now that some are unemployed are also able to see how personal health condition is essential to survive even to a (perhaps but not for certainty) more virulent seasonal human influenza strain.

 

[HenryN]

Re: County Seasonal flu alert (Influenza in Japan)

Thank you Dr. Niman, Commonground and AD.


By summing and extracting from all these translated/commented texts (thanks to FT we can have news which were negated from big int. health "watcher" institutions and other "news at the glance" TV),
it seems that:

#51 (Rec.txt):
"...
Thus, at this time the H1N1 in Japan has H274Y which creates Tamiflu resistance, but it also has evolved away from the 2007 strain, so it is also vaccine resistant.

Chasing Tamiflu resistant H1N1 with mismatched vaccines is hazardous to the worlds health because of diminished protection and an increased risk if dual infections involving H1N1 and H5N1 leading to Tamiflu resistant H5N1.
..."

I shall try to resume with an (?) (maybe wrongly) the here cited situation for the ones who wants to make more clear the level of danger at the moment
(because there were so much texts about, and this can be confusing for the non health specialists FT readers).

The recent worldwide episodes (one displayed yesterday during an country media release on TV direct) of rapid gripping unconsiousness, pneumonia, and other mixed simptoms, are coming from this evolved AH1N1 Tamiflu and seasonal vaccine resistant flu strain. (?)

It was already in S.Corea, parts of Russia/China, now it is in Japan, and it is/should (?) spread wide in USA/EU, where is already present in minor quantity than now in Japan.(?)

Additionaly, now became clear that the previous (2007) form of AH1N1 resistant to Tamiflu and quoted with relative inoque gravity, changed, and now became more infectious, wide spread, and with serious outcomes to the infected ones (?)

Feel it free to correct the above if incorrect.

The H1N1 in Asia is producing widespread infections that are at levels that are higher than recent years. The weekly reports from South Korea showed this rise via influenza-like illness reports by physicians. Similar reports from Japan began showing the same trend last week. The levels are at historic highs, not just highs for this season.

The subclade producing these highs is Tamiflu resistant and vaccine resistant. The reactivity is generally 4-8 fold lower than the immunizing virus, and 16-32 fold lower in additional cases, so the H1N1 is not easily controled by traditional methods.
It is likely that the results seen in Korea and Japan will be seen in additional countries were H1N1 dominates, such as China and the United States.
China is a bigger concern because H5N1 is circulating and a dual infection could generate Tamiflu resistant H5N1.

 

[HenryN]

Re: County Seasonal flu alert (Influenza in Japan)

A major antigenic drift variation in an human influenza virus cannot be discounted, when there is still a lack of information from authoritative sources (WHO or others). In the past happened, when several intrasubtypic variations created strains of H1N1 with enhanced virulence ('40 of XX century).

The reports of lower titers comes from the NIH in Japan. Google translation:

http://66.102.1.101/translate_c?hl=en&sl=ja&u=http://idsc.nih.go.jp/iasr/rapid/pr3491.html&prev=/search%3Fq%3Dh275y%26hl%3Den%26lr%3D%26rlz%3D1T4GGLL_enUS305US306%26as_qdr%3Dd&usg=ALkJrhj1W8WRGxiRtsUtEEODDwMXTH6C4A

Yahoo translation

AH1 sub- type virus: With system of our HI tests as for homo- value of the vaccine stocks antigen for the antibody of infection research distribution 1: 640 is. Vis-a-vis this, the majority of separated virus 61 stocks of former Sendai medical institution origin, 1: 80 - 160 and 2 - 3 tubes to be lower than homo- value, in 1: 40 and 1: 20 (each 1 stocks) with, largely there were also some which have slipped. In addition, virus 11 stocks of the Fukuoka medical institution origin which is separated so far all HI values 1: 80 was, had slipped largely. Furthermore, these do not react vis-a-vis the antiserum for a/SOLOMON stocks which are AH1 sub- form chin stocks of last year completely (1: <10).