tetano
Editor, Senior Moderator
Int J Infect Dis. 2018 Jun 12. pii: S1201-9712(18)34434-5. doi: 10.1016/j.ijid.2018.05.024. [Epub ahead of print]
[h=1]Cost-Effectiveness Analysis of Universal Influenza Vaccination: Application of Susceptible-Infectious-Complication-Recovery Model.[/h] Yang KC[SUP]1[/SUP], Hung HF[SUP]2[/SUP], Chen MK[SUP]2[/SUP], Chen LS[SUP]3[/SUP], Fann JC[SUP]4[/SUP], Chiu SY[SUP]5[/SUP], Yen AF[SUP]3[/SUP], Huang KC[SUP]6[/SUP], Chen HH[SUP]7[/SUP], Wang ST[SUP]8[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] Despite the fact that vaccination is an effective primary prevention strategy for containing influenza outbreak, health policymakers show great concern over enormous costs involved in universal immunization particularly when resources are limited.
[h=4]METHODS:[/h] We conducted a two-arm cost-effectiveness analysis (CEA) that takes into account the aspect of herd immunity, using a study cohort that was composed of 100,000 residents with the make-up of demographic characteristics identical to those of the underlying population in Taipei County, Taiwan, during the epidemic influenza season of 2001-2002. The parameters embedded in the dynamic process of infection were estimated by the application of the newly proposed susceptible-infection-complication-recovery model to the empirical data in order to compute the number of deaths and complications averted due to universal vaccination compared to non-vaccination. Incremental cost-effectiveness ratios (ICERs) and cost-effectiveness acceptability curve (CEAC) given maximum amount of willingness-to-pay (WTP) were calculated to delineate the results of the two-arm CEA.
[h=4]RESULTS:[/h] Incremental costs involved in the vaccinated group as opposed to the unvaccinated group was $1,195 for reducing one additional complication and $805 for averting one additional death, allowing for herd immunity. The corresponding figures were higher for the results without considering herd immunity. Given the ceiling ratio of willingness-to-pay (WTP) equal to $10,000 (approximately two-thirds of the GDP), the probability of being cost-effective for vaccination was 100% and 96.7% for averting death and complications, respectively.
[h=4]CONCLUSIONS:[/h] Universal vaccination against seasonal influenza was very cost-effective particularly when herd immunity is considered. The probability of being cost-effective was almost certain given the maximum amount of WTP within two-thirds of the GDP.
Copyright ? 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
[h=4]KEYWORDS:[/h] cost-effectiveness analysis; dynamic model; herd immunity; influenza
PMID: 29906602 DOI: 10.1016/j.ijid.2018.05.024
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[h=1]Cost-Effectiveness Analysis of Universal Influenza Vaccination: Application of Susceptible-Infectious-Complication-Recovery Model.[/h] Yang KC[SUP]1[/SUP], Hung HF[SUP]2[/SUP], Chen MK[SUP]2[/SUP], Chen LS[SUP]3[/SUP], Fann JC[SUP]4[/SUP], Chiu SY[SUP]5[/SUP], Yen AF[SUP]3[/SUP], Huang KC[SUP]6[/SUP], Chen HH[SUP]7[/SUP], Wang ST[SUP]8[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] Despite the fact that vaccination is an effective primary prevention strategy for containing influenza outbreak, health policymakers show great concern over enormous costs involved in universal immunization particularly when resources are limited.
[h=4]METHODS:[/h] We conducted a two-arm cost-effectiveness analysis (CEA) that takes into account the aspect of herd immunity, using a study cohort that was composed of 100,000 residents with the make-up of demographic characteristics identical to those of the underlying population in Taipei County, Taiwan, during the epidemic influenza season of 2001-2002. The parameters embedded in the dynamic process of infection were estimated by the application of the newly proposed susceptible-infection-complication-recovery model to the empirical data in order to compute the number of deaths and complications averted due to universal vaccination compared to non-vaccination. Incremental cost-effectiveness ratios (ICERs) and cost-effectiveness acceptability curve (CEAC) given maximum amount of willingness-to-pay (WTP) were calculated to delineate the results of the two-arm CEA.
[h=4]RESULTS:[/h] Incremental costs involved in the vaccinated group as opposed to the unvaccinated group was $1,195 for reducing one additional complication and $805 for averting one additional death, allowing for herd immunity. The corresponding figures were higher for the results without considering herd immunity. Given the ceiling ratio of willingness-to-pay (WTP) equal to $10,000 (approximately two-thirds of the GDP), the probability of being cost-effective for vaccination was 100% and 96.7% for averting death and complications, respectively.
[h=4]CONCLUSIONS:[/h] Universal vaccination against seasonal influenza was very cost-effective particularly when herd immunity is considered. The probability of being cost-effective was almost certain given the maximum amount of WTP within two-thirds of the GDP.
Copyright ? 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
[h=4]KEYWORDS:[/h] cost-effectiveness analysis; dynamic model; herd immunity; influenza
PMID: 29906602 DOI: 10.1016/j.ijid.2018.05.024
Free full text