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[h=2]Original Research[/h] [h=3]Special Report[/h]
[h=1]Congenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatally[/h]
Patricia Soares de Oliveira-Szejnfeld, MD, Deborah Levine, MD, Adriana Suely de Oliveira Melo, MD, PhD, Melania Maria Ramos Amorim, MD, PhD, Alba Gean M. Batista, MD, Leila Chimelli, MD, PhD, Amilcar Tanuri, MD, PhD, Renato Santana Aguiar, PhD,Gustavo Malinger, MD, PhD, Renato Ximenes, MD, Richard Robertson, MD, Jacob Szejnfeld, MD, PhD, Fernanda Tovar-Moll, MD, PhD
From the Dept of Diagnostic Imaging, Federal Univ of S?o Paulo, S?o Paulo, Brazil (P.S.d.O.S., R.X., J.S.); Foundation Inst for Education and Research in Diagnostic Imaging, Dept of Diagnostic Imaging, Federal Univ of S?o Paulo, S?o Paulo, Brazil (P.S.d.O.S., J.S.); Dept of Radiology, Beth Israel Deaconess Medical Ctr, Harvard Medical School, Boston, Mass (D.L.); Instituto de Pesquisa Professor Amorim Neto, Campina Grande, PB, Brazil (A.S.d.O.M., M.M.R.A.); Instituto de Sa?de Elpidio de Almeida, Campina Grande, PB, Brazil (A.S.d.O.M., M.M.R.A.); Faculdade de Ci?ncias M?dicas de Campina Grande, Campina Grande, PB, Brazil (A.S.d.O.M.); Hosp Municipal Pedro I, Servi?o Municipal de Atendimento Transdisciplinar a Gestantes e Beb?s com Infec??o Cong?nita por Zika Virus, Campina Grande, PB, Brazil (A.S.d.O.M., A.G.M.B.); Universidade Federal de Campina Grande, PB, Brazil (M.M.R.A.); Laboratory of Neuropathology, State Inst of Brain, Rio de Janeiro, Brazil (L.C.); Departamento de Gen?tica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil (A.T., R.S.A.); Div of Ultrasound in Obstetrics & Gynecology, Lis Maternity Hosp, Tel Aviv Sourasky Medical Ctr, Sackler Faculty of Medicine, Tel Aviv Univ, Tel Aviv, Israel (G.M.); Fetal Medicine Foundation Latinamerica?FMFLA, Centrus?Fetal Medicine, Campinas, Brazil (R.X.); Boston Children?s Hosp, Boston, Mass (R.R.); Inst of Biomedical Sciences and National Ctr for Structural Biology and Bioimaging, Federal Univ of Rio de Janeiro, Rio de Janeiro, Brazil (F.T.M.); and D?Or Inst for Research and Education, Rua Diniz Cordeiro 30, Botafogo, Rio de Janeiro, RJ, Brazil 22881-100 (F.T.M.).
Address correspondence to F.T.M. (e-mail: Fernanda.tovarmoll@idor.org).
DOI: http://dx.doi.org/10.1148/radiol.2016161584
Introduction
Section:
ChooseChooseTop of pageAbstractIntroduction <<Materials and MethodsResultsDiscussionReferences prevnext
Much has been written recently regarding Zika virus in pregnancy and the increased risk of microcephaly in fetuses exposed to the virus. The outbreak of infection in Brazil, especially in the northeast part of the country (1), has been of particular concern. The virus has been found in the fluids of pregnant mothers and during autopsy in the brains of neonates with microcephaly (2?5). Much of the concern in the media regarding the teratogenicity of Zika virus infection has focused on brain findings of microcephaly. However, as documented in many case series, there are a variety of brain abnormalities that can be found in fetuses exposed to intrauterine Zika virus infection (2?11). These include abnormalities in ventricular size, gray and white matter volume loss, brainstem abnormalities, and calcifications.
Although the current outbreak has centered in Brazil, according to the U.S. Centers for Disease Control and Prevention, there are currently 51 countries or territories in which active transmission of Zika virus has been reported (12). It is important for radiologists to understand the type of abnormalities associated with congenital Zika virus infection to aid in recognition of disease and appropriate counseling of patients. The purpose of this special report is to document the imaging findings associated with congenital Zika virus infection as found in patients seen at the Instituto de Pesquisa in Campina Grande State Paraiba (IPESQ) in northeastern Brazil.
...
http://pubs.rsna.org/doi/full/10.1148/radiol.2016161584
[h=1]Congenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatally[/h]
Patricia Soares de Oliveira-Szejnfeld, MD, Deborah Levine, MD, Adriana Suely de Oliveira Melo, MD, PhD, Melania Maria Ramos Amorim, MD, PhD, Alba Gean M. Batista, MD, Leila Chimelli, MD, PhD, Amilcar Tanuri, MD, PhD, Renato Santana Aguiar, PhD,Gustavo Malinger, MD, PhD, Renato Ximenes, MD, Richard Robertson, MD, Jacob Szejnfeld, MD, PhD, Fernanda Tovar-Moll, MD, PhD
From the Dept of Diagnostic Imaging, Federal Univ of S?o Paulo, S?o Paulo, Brazil (P.S.d.O.S., R.X., J.S.); Foundation Inst for Education and Research in Diagnostic Imaging, Dept of Diagnostic Imaging, Federal Univ of S?o Paulo, S?o Paulo, Brazil (P.S.d.O.S., J.S.); Dept of Radiology, Beth Israel Deaconess Medical Ctr, Harvard Medical School, Boston, Mass (D.L.); Instituto de Pesquisa Professor Amorim Neto, Campina Grande, PB, Brazil (A.S.d.O.M., M.M.R.A.); Instituto de Sa?de Elpidio de Almeida, Campina Grande, PB, Brazil (A.S.d.O.M., M.M.R.A.); Faculdade de Ci?ncias M?dicas de Campina Grande, Campina Grande, PB, Brazil (A.S.d.O.M.); Hosp Municipal Pedro I, Servi?o Municipal de Atendimento Transdisciplinar a Gestantes e Beb?s com Infec??o Cong?nita por Zika Virus, Campina Grande, PB, Brazil (A.S.d.O.M., A.G.M.B.); Universidade Federal de Campina Grande, PB, Brazil (M.M.R.A.); Laboratory of Neuropathology, State Inst of Brain, Rio de Janeiro, Brazil (L.C.); Departamento de Gen?tica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil (A.T., R.S.A.); Div of Ultrasound in Obstetrics & Gynecology, Lis Maternity Hosp, Tel Aviv Sourasky Medical Ctr, Sackler Faculty of Medicine, Tel Aviv Univ, Tel Aviv, Israel (G.M.); Fetal Medicine Foundation Latinamerica?FMFLA, Centrus?Fetal Medicine, Campinas, Brazil (R.X.); Boston Children?s Hosp, Boston, Mass (R.R.); Inst of Biomedical Sciences and National Ctr for Structural Biology and Bioimaging, Federal Univ of Rio de Janeiro, Rio de Janeiro, Brazil (F.T.M.); and D?Or Inst for Research and Education, Rua Diniz Cordeiro 30, Botafogo, Rio de Janeiro, RJ, Brazil 22881-100 (F.T.M.).
Address correspondence to F.T.M. (e-mail: Fernanda.tovarmoll@idor.org).
DOI: http://dx.doi.org/10.1148/radiol.2016161584
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Introduction
Section:
ChooseChooseTop of pageAbstractIntroduction <<Materials and MethodsResultsDiscussionReferences prevnext
Much has been written recently regarding Zika virus in pregnancy and the increased risk of microcephaly in fetuses exposed to the virus. The outbreak of infection in Brazil, especially in the northeast part of the country (1), has been of particular concern. The virus has been found in the fluids of pregnant mothers and during autopsy in the brains of neonates with microcephaly (2?5). Much of the concern in the media regarding the teratogenicity of Zika virus infection has focused on brain findings of microcephaly. However, as documented in many case series, there are a variety of brain abnormalities that can be found in fetuses exposed to intrauterine Zika virus infection (2?11). These include abnormalities in ventricular size, gray and white matter volume loss, brainstem abnormalities, and calcifications.
Although the current outbreak has centered in Brazil, according to the U.S. Centers for Disease Control and Prevention, there are currently 51 countries or territories in which active transmission of Zika virus has been reported (12). It is important for radiologists to understand the type of abnormalities associated with congenital Zika virus infection to aid in recognition of disease and appropriate counseling of patients. The purpose of this special report is to document the imaging findings associated with congenital Zika virus infection as found in patients seen at the Instituto de Pesquisa in Campina Grande State Paraiba (IPESQ) in northeastern Brazil.
...
http://pubs.rsna.org/doi/full/10.1148/radiol.2016161584