tetano
Editor, Senior Moderator
Immunol Res. 2012 Apr 28. [Epub ahead of print]
Computational approaches to understanding dendritic cell responses to influenza virus infection.
Zaslavsky E, Hayot F, Sealfon SC.
Source
Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY, 10029-6574, USA.
Abstract
The evolution of immunology research from measurements of single entities to large-scale data-intensive assays necessitates the integration of experimental work with bioinformatics and computational approaches. The introduction of physics into immunology has led to the study of new phenomena, such as cellular noise, which is likely to prove increasingly important to understand immune system responses. The fusion of "hard science" and biology is also leading to a re-examination of data acquisition, analysis, and statistical validation and is resulting in the development of easy-to-access tools for immunology research. Here, we review some of our models, computational tools, and results related to studies of the innate immune response of human dendritic cells to viral infection. Our project functions on an open model across institutions with electronic record keeping and public sharing of data. Our tools, models, and data can be accessed at http://tsb.mssm.edu/primeportal/ .
PMID:
22544465
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22544465
Computational approaches to understanding dendritic cell responses to influenza virus infection.
Zaslavsky E, Hayot F, Sealfon SC.
Source
Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY, 10029-6574, USA.
Abstract
The evolution of immunology research from measurements of single entities to large-scale data-intensive assays necessitates the integration of experimental work with bioinformatics and computational approaches. The introduction of physics into immunology has led to the study of new phenomena, such as cellular noise, which is likely to prove increasingly important to understand immune system responses. The fusion of "hard science" and biology is also leading to a re-examination of data acquisition, analysis, and statistical validation and is resulting in the development of easy-to-access tools for immunology research. Here, we review some of our models, computational tools, and results related to studies of the innate immune response of human dendritic cells to viral infection. Our project functions on an open model across institutions with electronic record keeping and public sharing of data. Our tools, models, and data can be accessed at http://tsb.mssm.edu/primeportal/ .
PMID:
22544465
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22544465