tetano
Editor, Senior Moderator
Influenza Other Respi Viruses. 2012 Jun 14. doi: 10.1111/j.1750-2659.2012.00387.x. [Epub ahead of print]
Comparisons of oseltamivir-resistant (H275Y) and concurrent oseltamivir-susceptible seasonal influenza A(H1N1) virus infections in hospitalized adults, 2008-2009.
Chan MC, Lee N, Lui GC, Ngai KK, Wong RY, Choi KW, Chan PK.
Source
Department of Microbiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China Division of Infectious Diseases, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China Stanley Ho Centre for Emerging Infectious Diseases, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Abstract
Please cite this paper as: Chan et al. (2012) Comparisons of oseltamivir-resistant (H275Y) and concurrent oseltamivir-susceptible seasonal influenza A(H1N1) virus infections in hospitalized adults, 2008-2009. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2012.00387.x. In an observational cohort study, we found that adults hospitalized for oseltamivir-resistant (H275Y) seasonal H1N1 influenza (n = 46) were older than those infected with oseltamivir-susceptible strains (n = 31) [74(IQR 59-83) versus 64(IQR 48-76) years; P = 0?045], and most had major comorbidities (78% versus 65%). Disease severity and clinical outcomes were comparable between the two groups: radiographic pneumonia 40-42%, supplemental oxygen use 47-48%, critical illness 11-13%, median duration of hospitalization 5-6 days, death rate 6-9%. Failure to receive effective antiviral therapy was associated with progression to critical illness (23% versus 0%, P = 0?016) and death (20% versus 0%, P = 0?033) in hospitalized patients with seasonal H1N1 influenza.
? 2012 Blackwell Publishing Ltd.
PMID:
22694153
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22694153
Comparisons of oseltamivir-resistant (H275Y) and concurrent oseltamivir-susceptible seasonal influenza A(H1N1) virus infections in hospitalized adults, 2008-2009.
Chan MC, Lee N, Lui GC, Ngai KK, Wong RY, Choi KW, Chan PK.
Source
Department of Microbiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China Division of Infectious Diseases, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China Stanley Ho Centre for Emerging Infectious Diseases, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Abstract
Please cite this paper as: Chan et al. (2012) Comparisons of oseltamivir-resistant (H275Y) and concurrent oseltamivir-susceptible seasonal influenza A(H1N1) virus infections in hospitalized adults, 2008-2009. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2012.00387.x. In an observational cohort study, we found that adults hospitalized for oseltamivir-resistant (H275Y) seasonal H1N1 influenza (n = 46) were older than those infected with oseltamivir-susceptible strains (n = 31) [74(IQR 59-83) versus 64(IQR 48-76) years; P = 0?045], and most had major comorbidities (78% versus 65%). Disease severity and clinical outcomes were comparable between the two groups: radiographic pneumonia 40-42%, supplemental oxygen use 47-48%, critical illness 11-13%, median duration of hospitalization 5-6 days, death rate 6-9%. Failure to receive effective antiviral therapy was associated with progression to critical illness (23% versus 0%, P = 0?016) and death (20% versus 0%, P = 0?033) in hospitalized patients with seasonal H1N1 influenza.
? 2012 Blackwell Publishing Ltd.
PMID:
22694153
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22694153