tetano
Editor, Senior Moderator
Vaccine. 2014 Dec 26. pii: S0264-410X(14)01672-7. doi: 10.1016/j.vaccine.2014.12.029. [Epub ahead of print]
[h=1]Comparison of severely ill patients with influenza A(H1N1)pdm09 infection during the pandemic and post-pandemic periods in Singapore.[/h] Lim C[SUP]1[/SUP], Ang LW[SUP]2[/SUP], Ma S[SUP]2[/SUP], Lai FY[SUP]2[/SUP], James L[SUP]2[/SUP], Cutter J[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND/OBJECTIVES:[/h] Singapore is a tropical country with influenza seasons occurring bi-annually. We compared the profile of severely ill patients with laboratory confirmed influenza A(H1N1)pdm09 infection in Singapore during the pandemic and post-pandemic periods, and studied their risk factors associated with mortality.
[h=4]PATIENTS/METHODS:[/h] Three periods were defined for this study; pandemic period from 18 June to 29 August 2009, early post-pandemic period from 30 August 2009 to 12 February 2010, and late post-pandemic period from 13 February to 10 August 2010.
[h=4]RESULTS:[/h] A total of 172 severely ill patients were admitted to hospitals from 18 June 2009 to 10 August 2010, of whom 23.8% died. The median age in the late post-pandemic period was significantly older than that in the early post-pandemic period (52 years versus 35 years, P=0.02). The median age of patients who died was significantly older than those who survived (52 years versus 44 years, P<0.01). The median length of stay under intensive care in the late post-pandemic period was twice that in the early post-pandemic (6 days versus 3 days, P=0.045). The proportion who died in the late post-pandemic period was more than 2.5 times that in the early post-pandemic period (29.8% versus 11.1%, P=0.043).
[h=4]CONCLUSIONS:[/h] Severely ill patients were of older age in the late post-pandemic period. Older age was also significantly associated with mortality. It is important to maintain heightened vigilance and continue the surveillance of severely ill patients with influenza post-pandemic, so that patients with suspected infections could be promptly identified for early diagnosis and treatment.
Copyright ? 2014. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] A(H1N1)pdm09; Hospitalisation; Mortality; Pandemic
PMID: 25545594 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25545594
[h=1]Comparison of severely ill patients with influenza A(H1N1)pdm09 infection during the pandemic and post-pandemic periods in Singapore.[/h] Lim C[SUP]1[/SUP], Ang LW[SUP]2[/SUP], Ma S[SUP]2[/SUP], Lai FY[SUP]2[/SUP], James L[SUP]2[/SUP], Cutter J[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND/OBJECTIVES:[/h] Singapore is a tropical country with influenza seasons occurring bi-annually. We compared the profile of severely ill patients with laboratory confirmed influenza A(H1N1)pdm09 infection in Singapore during the pandemic and post-pandemic periods, and studied their risk factors associated with mortality.
[h=4]PATIENTS/METHODS:[/h] Three periods were defined for this study; pandemic period from 18 June to 29 August 2009, early post-pandemic period from 30 August 2009 to 12 February 2010, and late post-pandemic period from 13 February to 10 August 2010.
[h=4]RESULTS:[/h] A total of 172 severely ill patients were admitted to hospitals from 18 June 2009 to 10 August 2010, of whom 23.8% died. The median age in the late post-pandemic period was significantly older than that in the early post-pandemic period (52 years versus 35 years, P=0.02). The median age of patients who died was significantly older than those who survived (52 years versus 44 years, P<0.01). The median length of stay under intensive care in the late post-pandemic period was twice that in the early post-pandemic (6 days versus 3 days, P=0.045). The proportion who died in the late post-pandemic period was more than 2.5 times that in the early post-pandemic period (29.8% versus 11.1%, P=0.043).
[h=4]CONCLUSIONS:[/h] Severely ill patients were of older age in the late post-pandemic period. Older age was also significantly associated with mortality. It is important to maintain heightened vigilance and continue the surveillance of severely ill patients with influenza post-pandemic, so that patients with suspected infections could be promptly identified for early diagnosis and treatment.
Copyright ? 2014. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] A(H1N1)pdm09; Hospitalisation; Mortality; Pandemic
PMID: 25545594 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25545594