tetano
Editor, Senior Moderator
J Korean Med Sci. 2013 Feb;28(2):274-9. doi: 10.3346/jkms.2013.28.2.274. Epub 2013 Jan 29.
Comparison of Immune Response by Virus Infection and Vaccination to 2009 Pandemic Influenza A/H1N1 in Children.
Kang EK, Lim JS, Lee JA, Kim DH.
Source
Department of Pediatrics, Dongguk University Ilsan Hospital, Goyang, Korea.
Abstract
We aimed to compare the immune response induced by natural infection with 2009 pandemic influenza A/H1N1 (pH1N1) virus and by monovalent pH1N1 vaccination in children and adolescents. This cross-sectional clinical study was conducted at 3 hospitals in Korea from February to May 2010. A total of 266 healthy subjects aged from 6 months to 18 yr were tested for the presence of the antibody against pH1N1 using hemagglutination inhibition (HI) test. Information about pH1N1 vaccination and laboratory-confirmed pH1N1 infection history was obtained. The overall rate of HI titers of ≥ 1:40 against pH1N1 was 38.7%, and the geometric mean titer (GMT) was 20.5. Immunogenicity of pH1N1 vaccination only was reflected by a 41.1% of seroprotection rate and a GMT of 22.5. Immunogenicity of natural infection only was reflected by a 61.0% of seroprotection rate and a GMT of 40.0. GMT was significantly higher in the subjects of natural infection group than in the subjects of pH1N1 vaccination group (P < 0.001). The immune responses induced by natural pH1N1 infection exceed those induced by pH1N1 vaccinations.
KEYWORDS:
Child, Immune Response, Natural Infection, Pandemic Influenza A, Vaccination
PMID:
23399558
[PubMed - in process]
PMCID:
PMC3565140
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/23399558
Comparison of Immune Response by Virus Infection and Vaccination to 2009 Pandemic Influenza A/H1N1 in Children.
Kang EK, Lim JS, Lee JA, Kim DH.
Source
Department of Pediatrics, Dongguk University Ilsan Hospital, Goyang, Korea.
Abstract
We aimed to compare the immune response induced by natural infection with 2009 pandemic influenza A/H1N1 (pH1N1) virus and by monovalent pH1N1 vaccination in children and adolescents. This cross-sectional clinical study was conducted at 3 hospitals in Korea from February to May 2010. A total of 266 healthy subjects aged from 6 months to 18 yr were tested for the presence of the antibody against pH1N1 using hemagglutination inhibition (HI) test. Information about pH1N1 vaccination and laboratory-confirmed pH1N1 infection history was obtained. The overall rate of HI titers of ≥ 1:40 against pH1N1 was 38.7%, and the geometric mean titer (GMT) was 20.5. Immunogenicity of pH1N1 vaccination only was reflected by a 41.1% of seroprotection rate and a GMT of 22.5. Immunogenicity of natural infection only was reflected by a 61.0% of seroprotection rate and a GMT of 40.0. GMT was significantly higher in the subjects of natural infection group than in the subjects of pH1N1 vaccination group (P < 0.001). The immune responses induced by natural pH1N1 infection exceed those induced by pH1N1 vaccinations.
KEYWORDS:
Child, Immune Response, Natural Infection, Pandemic Influenza A, Vaccination
PMID:
23399558
[PubMed - in process]
PMCID:
PMC3565140
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/23399558