tetano
Editor, Senior Moderator
Eur J Clin Microbiol Infect Dis. 2020 Jan 27. doi: 10.1007/s10096-020-03822-x. [Epub ahead of print] [h=1]Comparison of clinical outcomes of influenza A and B at the 2017-2018 influenza season: a cohort study.[/h]
Avni T[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Babich T[SUP]2,[/SUP][SUP]3[/SUP], Nir A[SUP]3[/SUP], Yahav D[SUP]1,[/SUP][SUP]3[/SUP], Shaked H[SUP]1,[/SUP][SUP]3[/SUP], Sorek N[SUP]4[/SUP], Zvi HB[SUP]4[/SUP], Bishara J[SUP]1,[/SUP][SUP]3[/SUP], Atamna A[SUP]5,[/SUP][SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza has significant morbidity and mortality. Some experts consider infection with influenza B as milder than that with influenza A. The objective of this study is to evaluate the outcomes of hospitalized patients with laboratory-confirmed influenza A or B in 2017-2018 influenza season. All hospitalized patients between October 2017 and April 2018 with laboratory-confirmed influenza A and B were included. The primary composite outcomes were pneumonia/myocarditis/encephalitis, mechanical ventilation, ICU admission, and 30-day mortality. Secondary outcomes were 30-/90-day mortality, length of hospital stay, and readmission rates. The study included 201 influenza A and 325 influenza B. For the primary composite outcome, no significant difference was demonstrated between influenza A and B. Rates of mortality were similar at 30 and 90 days. Influenza A had higher pneumonia rates and mechanical ventilation. On multivariate analysis, higher Charlson's score, hypoalbuminemia, and vasopressor use were associated with 30-day mortality, while infection with either influenza A or B was not. Influenza A was associated with higher pneumonia and mechanical ventilation rates. However, influenza B resulted with similar 30-day mortality rate as influenza A.
[h=4]KEYWORDS:[/h] H1N1; H3N2; Influenza; Mortality; Pneumonia
PMID: 31989376 DOI: 10.1007/s10096-020-03822-x
Avni T[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Babich T[SUP]2,[/SUP][SUP]3[/SUP], Nir A[SUP]3[/SUP], Yahav D[SUP]1,[/SUP][SUP]3[/SUP], Shaked H[SUP]1,[/SUP][SUP]3[/SUP], Sorek N[SUP]4[/SUP], Zvi HB[SUP]4[/SUP], Bishara J[SUP]1,[/SUP][SUP]3[/SUP], Atamna A[SUP]5,[/SUP][SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza has significant morbidity and mortality. Some experts consider infection with influenza B as milder than that with influenza A. The objective of this study is to evaluate the outcomes of hospitalized patients with laboratory-confirmed influenza A or B in 2017-2018 influenza season. All hospitalized patients between October 2017 and April 2018 with laboratory-confirmed influenza A and B were included. The primary composite outcomes were pneumonia/myocarditis/encephalitis, mechanical ventilation, ICU admission, and 30-day mortality. Secondary outcomes were 30-/90-day mortality, length of hospital stay, and readmission rates. The study included 201 influenza A and 325 influenza B. For the primary composite outcome, no significant difference was demonstrated between influenza A and B. Rates of mortality were similar at 30 and 90 days. Influenza A had higher pneumonia rates and mechanical ventilation. On multivariate analysis, higher Charlson's score, hypoalbuminemia, and vasopressor use were associated with 30-day mortality, while infection with either influenza A or B was not. Influenza A was associated with higher pneumonia and mechanical ventilation rates. However, influenza B resulted with similar 30-day mortality rate as influenza A.
[h=4]KEYWORDS:[/h] H1N1; H3N2; Influenza; Mortality; Pneumonia
PMID: 31989376 DOI: 10.1007/s10096-020-03822-x