Comparative virus replication and host innate response in human cells infected with 3 prevalent clades (2.3.4, 2.3.2 and 7) of highly pathogenic avian

[tetano]

J Virol. 2013 Oct 16. [Epub ahead of print]
Comparative virus replication and host innate response in human cells infected with 3 prevalent clades (2.3.4, 2.3.2 and 7) of highly pathogenic avian influenza H5N1 viruses.
Sun H, Sun Y, Pu J, Zhang Y, Zhu Q, Li J, Gu J, Chang KC, Liu J.
Source

Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Abstract

Highly pathogenic avian influenza H5N1 virus clades 2.3.4, 2.3.2 and 7 are the dominant co-circulating H5N1 viruses in poultry in China. However, humans appear to be clinically susceptible mostly to the 2.3.4 virus clade. Here, we demonstrated that A549 cells and human macrophages infected with clade 2.3.4 viruses produced significantly more viruses than those infected with the other two clades. Likewise, clade 2.3.4 infected macrophages caused the most severe cellular damage and strongest pro-inflammatory response.

PMID:
24131718
[PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24131718