tetano
Editor, Senior Moderator
Biomed Pharmacother. 2016 Jul 29;83:755-762. doi: 10.1016/j.biopha.2016.07.046. [Epub ahead of print]
[h=1]Comparative study on the antioxidant capacities of synthetic influenza inhibitors and ellagic acid in model systems.[/h] Pavlova EL[SUP]1[/SUP], Zografov NN[SUP]2[/SUP], Simeonova LS[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] This study compares the antioxidant capacities in vitro of several synthetic and natural compounds applied and researched for influenza treatment - oseltamivir, isoprinosine, ellagic acid, vitamin E and vitamin C. Three chemical systems are utilized for the generation of reactive oxygen species (ROS) at pH 7.4 and pH 8.5: (1) Fenton's (Fe[SUP]2+[/SUP]+H[SUB]2[/SUB]O[SUB]2[/SUB]) for OH and -OH species (2) H[SUB]2[/SUB]O[SUB]2[/SUB] (3) NADH-phenazinemethosulfat, for superoxide radicals (O[SUB]2[/SUB][SUP]-[/SUP]). The kinetics was evaluated by lucigenin-enhanced chemiluminescence. The calculated constants of inhibition k[SUB]7[/SUB] describe the antioxidant capacity at the moment of oxidative burst. Their values do not necessarily correspond to the calculated total antioxidant activity. The obtained results revealed that the synthetic anti-influenza drugs (oseltamivir and isoprinosine) as well as ellagic acid possess pronounced scavenging properties mostly against superoxide radicals, comparable and higher than that of traditional natural antioxidants. Quantitative analysis of the antioxidant effects of the examined synthetic substances was performed. The results compared the corresponding effect of the average physiological concentrations and the applied therapeutic antioxidant dose. With these experiments we registered new aspects of their therapeutic activities, due to antioxidant properties against hydroxyl, superoxide radicals and H[SUB]2[/SUB]O[SUB]2[/SUB] oxidation.
Copyright ? 2016 Elsevier Masson SAS. All rights reserved.
[h=4]KEYWORDS:[/h] Constant of inhibition; Ellagic acid; Ellagic acid (PubChem CID 5281855); Isoprinosine; Isoprinosine (PubChem CID 37510); Luminescence; Oseltamivir; Oseltamivir (PubChem CID 65028); Vitamin C; Vitamin C (PubChem CID 54670067); Vitamin E; Vitamin E (PubChem CID 20353)
PMID: 27479194 DOI: 10.1016/j.biopha.2016.07.046
[PubMed - as supplied by publisher]
[h=1]Comparative study on the antioxidant capacities of synthetic influenza inhibitors and ellagic acid in model systems.[/h] Pavlova EL[SUP]1[/SUP], Zografov NN[SUP]2[/SUP], Simeonova LS[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] This study compares the antioxidant capacities in vitro of several synthetic and natural compounds applied and researched for influenza treatment - oseltamivir, isoprinosine, ellagic acid, vitamin E and vitamin C. Three chemical systems are utilized for the generation of reactive oxygen species (ROS) at pH 7.4 and pH 8.5: (1) Fenton's (Fe[SUP]2+[/SUP]+H[SUB]2[/SUB]O[SUB]2[/SUB]) for OH and -OH species (2) H[SUB]2[/SUB]O[SUB]2[/SUB] (3) NADH-phenazinemethosulfat, for superoxide radicals (O[SUB]2[/SUB][SUP]-[/SUP]). The kinetics was evaluated by lucigenin-enhanced chemiluminescence. The calculated constants of inhibition k[SUB]7[/SUB] describe the antioxidant capacity at the moment of oxidative burst. Their values do not necessarily correspond to the calculated total antioxidant activity. The obtained results revealed that the synthetic anti-influenza drugs (oseltamivir and isoprinosine) as well as ellagic acid possess pronounced scavenging properties mostly against superoxide radicals, comparable and higher than that of traditional natural antioxidants. Quantitative analysis of the antioxidant effects of the examined synthetic substances was performed. The results compared the corresponding effect of the average physiological concentrations and the applied therapeutic antioxidant dose. With these experiments we registered new aspects of their therapeutic activities, due to antioxidant properties against hydroxyl, superoxide radicals and H[SUB]2[/SUB]O[SUB]2[/SUB] oxidation.
Copyright ? 2016 Elsevier Masson SAS. All rights reserved.
[h=4]KEYWORDS:[/h] Constant of inhibition; Ellagic acid; Ellagic acid (PubChem CID 5281855); Isoprinosine; Isoprinosine (PubChem CID 37510); Luminescence; Oseltamivir; Oseltamivir (PubChem CID 65028); Vitamin C; Vitamin C (PubChem CID 54670067); Vitamin E; Vitamin E (PubChem CID 20353)
PMID: 27479194 DOI: 10.1016/j.biopha.2016.07.046
[PubMed - as supplied by publisher]