tetano
Editor, Senior Moderator
J Pediatr. 2016 Mar 17. pii: S0022-3476(16)00271-7. doi: 10.1016/j.jpeds.2016.02.049. [Epub ahead of print]
[h=1]Community-Acquired Pneumonia Hospitalization among Children with Neurologic Disorders.[/h] Millman AJ[SUP]1[/SUP], Finelli L[SUP]2[/SUP], Bramley AM[SUP]2[/SUP], Peacock G[SUP]3[/SUP], Williams DJ[SUP]4[/SUP], Arnold SR[SUP]5[/SUP], Grijalva CG[SUP]4[/SUP], Anderson EJ[SUP]6[/SUP], McCullers JA[SUP]7[/SUP], Ampofo K[SUP]8[/SUP], Pavia AT[SUP]8[/SUP], Edwards KM[SUP]4[/SUP], Jain S[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] To describe and compare the clinical characteristics, outcomes, and etiology of pneumonia among children hospitalized with community-acquired pneumonia (CAP) with neurologic disorders, non-neurologic underlying conditions, and no underlying conditions.
[h=4]STUDY DESIGN:[/h] Children <18 years old hospitalized with clinical and radiographic CAP were enrolled at 3 US children's hospitals. Neurologic disorders included cerebral palsy, developmental delay, Down syndrome, epilepsy, non-Down syndrome chromosomal abnormalities, and spinal cord abnormalities. We compared the epidemiology, etiology, and clinical outcomes of CAP in children with neurologic disorders with those with non-neurologic underlying conditions, and those with no underlying conditions using bivariate, age-stratified, and multivariate logistic regression analyses.
[h=4]RESULTS:[/h] From January 2010-June 2012, 2358 children with radiographically confirmed CAP were enrolled; 280 (11.9%) had a neurologic disorder (52.1% of these individuals also had non-neurologic underlying conditions), 934 (39.6%) had non-neurologic underlying conditions only, and 1144 (48.5%) had no underlying conditions. Children with neurologic disorders were older and more likely to require intensive care unit (ICU) admission than children with non-neurologic underlying conditions and children with no underlying conditions; similar proportions were mechanically ventilated. In age-stratified analysis, children with neurologic disorders were less likely to have a pathogen detected than children with non-neurologic underlying conditions. In multivariate analysis, having a neurologic disorder was associated with ICU admission for children ≥2 years of age.
[h=4]CONCLUSIONS:[/h] Children with neurologic disorders hospitalized with CAP were less likely to have a pathogen detected and more likely to be admitted to the ICU than children without neurologic disorders.
Published by Elsevier Inc.
PMID: 27017483 [PubMed - as supplied by publisher] [h=1].[/h]
[h=1]Community-Acquired Pneumonia Hospitalization among Children with Neurologic Disorders.[/h] Millman AJ[SUP]1[/SUP], Finelli L[SUP]2[/SUP], Bramley AM[SUP]2[/SUP], Peacock G[SUP]3[/SUP], Williams DJ[SUP]4[/SUP], Arnold SR[SUP]5[/SUP], Grijalva CG[SUP]4[/SUP], Anderson EJ[SUP]6[/SUP], McCullers JA[SUP]7[/SUP], Ampofo K[SUP]8[/SUP], Pavia AT[SUP]8[/SUP], Edwards KM[SUP]4[/SUP], Jain S[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] To describe and compare the clinical characteristics, outcomes, and etiology of pneumonia among children hospitalized with community-acquired pneumonia (CAP) with neurologic disorders, non-neurologic underlying conditions, and no underlying conditions.
[h=4]STUDY DESIGN:[/h] Children <18 years old hospitalized with clinical and radiographic CAP were enrolled at 3 US children's hospitals. Neurologic disorders included cerebral palsy, developmental delay, Down syndrome, epilepsy, non-Down syndrome chromosomal abnormalities, and spinal cord abnormalities. We compared the epidemiology, etiology, and clinical outcomes of CAP in children with neurologic disorders with those with non-neurologic underlying conditions, and those with no underlying conditions using bivariate, age-stratified, and multivariate logistic regression analyses.
[h=4]RESULTS:[/h] From January 2010-June 2012, 2358 children with radiographically confirmed CAP were enrolled; 280 (11.9%) had a neurologic disorder (52.1% of these individuals also had non-neurologic underlying conditions), 934 (39.6%) had non-neurologic underlying conditions only, and 1144 (48.5%) had no underlying conditions. Children with neurologic disorders were older and more likely to require intensive care unit (ICU) admission than children with non-neurologic underlying conditions and children with no underlying conditions; similar proportions were mechanically ventilated. In age-stratified analysis, children with neurologic disorders were less likely to have a pathogen detected than children with non-neurologic underlying conditions. In multivariate analysis, having a neurologic disorder was associated with ICU admission for children ≥2 years of age.
[h=4]CONCLUSIONS:[/h] Children with neurologic disorders hospitalized with CAP were less likely to have a pathogen detected and more likely to be admitted to the ICU than children without neurologic disorders.
Published by Elsevier Inc.
PMID: 27017483 [PubMed - as supplied by publisher] [h=1].[/h]