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Community-acquired Oseltamivir-Resistant Pandemic (H1N1) 2009 in Child, Israel
- Thread starter tetano
- Start date
Giuseppe
Emeritus
Re: Community-acquired Oseltamivir-Resistant Pandemic (H1N1) 2009 in Child, Israel
Community-acquired Oseltamivir-Resistant Pandemic (H1N1) 2009 in Child, Israel (Emerg Infect Dis., extract, edited)
[Source: Emerging Infectious Diseses Journal, Full PDF Document (LINK). Extract, edited.]
DOI: 10.3201/eid1606.091875
Suggested citation for this article: Zonis Z, Englehard D, Hindiyeh M, Ram D, Mandelboim M, Mendelson E, et al. Community-acquired oseltamivir-resistant pandemic (H1N1) 2009 in child, Israel [letter]. Emerg Infect Dis. 2010 Jun; [Epub ahead of print]
Community-acquired Oseltamivir-Resistant Pandemic (H1N1) 2009 in Child, Israel
To the Editor:
During the spring of 2009, a pandemic influenza A (H1N1) virus emerged and spread globally. Initial testing of the virus found it susceptible to neuraminidase inhibitors and resistant to adamantanes (1,2). As of March 5, 2010, only 264 cases of oseltamivir- resistant pandemic (H1N1) 2009 infection had been reported to the World Health Organization, but the number of cases has been steadily increasing (2). These viruses were carrying the H275Y mutation, which conferred resistance to oseltamivir (2). Most of the reported cases were in immunocompromised patients who had prolonged viral shedding or in patients who had received oseltamivir prophylaxis or treatment (1?4). We describe an otherwise healthy 2-year-old boy with oseltamivir-resistant pandemic (H1N1) 2009 infection and a traumatic lung contusion, complicated by acute respiratory distress syndrome (ARDS). He had not received prior chemoprophylaxis or treatment with oseltamivir.
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Community-acquired Oseltamivir-Resistant Pandemic (H1N1) 2009 in Child, Israel (Emerg Infect Dis., extract, edited)
[Source: Emerging Infectious Diseses Journal, Full PDF Document (LINK). Extract, edited.]
DOI: 10.3201/eid1606.091875
Suggested citation for this article: Zonis Z, Englehard D, Hindiyeh M, Ram D, Mandelboim M, Mendelson E, et al. Community-acquired oseltamivir-resistant pandemic (H1N1) 2009 in child, Israel [letter]. Emerg Infect Dis. 2010 Jun; [Epub ahead of print]
Community-acquired Oseltamivir-Resistant Pandemic (H1N1) 2009 in Child, Israel
To the Editor:
During the spring of 2009, a pandemic influenza A (H1N1) virus emerged and spread globally. Initial testing of the virus found it susceptible to neuraminidase inhibitors and resistant to adamantanes (1,2). As of March 5, 2010, only 264 cases of oseltamivir- resistant pandemic (H1N1) 2009 infection had been reported to the World Health Organization, but the number of cases has been steadily increasing (2). These viruses were carrying the H275Y mutation, which conferred resistance to oseltamivir (2). Most of the reported cases were in immunocompromised patients who had prolonged viral shedding or in patients who had received oseltamivir prophylaxis or treatment (1?4). We describe an otherwise healthy 2-year-old boy with oseltamivir-resistant pandemic (H1N1) 2009 infection and a traumatic lung contusion, complicated by acute respiratory distress syndrome (ARDS). He had not received prior chemoprophylaxis or treatment with oseltamivir.
(...)
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